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Basal Eurasian

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Basal Eurasian is a proposed lineage of anatomically modern humans with reduced, or zero, Neanderthal admixture (ancestry) compared to other ancient non-Africans. Basal Eurasians represent a sister lineage to other Eurasians and may have originated from the Southern Middle East, specifically the Arabian Peninsula, or North Africa, and are said to have contributed ancestry to various West Eurasian, South Asian, and Central Asian as well as African groups. This Basal Eurasian component is also proposed to explain the lower archaic admixture among modern West Eurasians compared with East Eurasians, although alternatives without the need of such Basal admixture exist as well.[1] Basal Eurasian ancestry had likely admixed into West Eurasian groups present in West Asia as early as 26,000 years ago, prior to the Last Glacial Maximum, with this ancestry being subsequently spread by later migrations, such as those of the Anatolian Neolithic Farmers into Europe during the Holocene.[2]

Description

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A study by Lazaridis et al. in 2014 demonstrated that modern Europeans can be modelled as an admixture of three ancestral populations; Ancient North Eurasians (ANE), Western Hunter-Gatherers (WHG), and Early European Farmers (EEF).[3] This same study also showed that EEFs harbour ancestry from a hypothetical non-African 'ghost' population which the authors name 'Basal Eurasians'. This group, who have not yet been sampled from ancient remains, are thought to have diverged from all non-African populations c. 60,000 to 100,000 years ago, before non-Africans admixed with Neanderthals (c. 50,000 to 60,000 years ago) and diversified from each other. A second study by Lazaridis et al. in 2016 found that populations with higher levels of Basal Eurasian ancestry have lower levels of Neanderthal ancestry, which suggests that Basal Eurasians had lower levels of Neanderthal ancestry compared with other non-Africans. Another study by Ferreira et al. in 2021 suggested that Basal Eurasians diverged from other Eurasians between 50,000 and 60,000 years ago, and lived somewhere in the Arabian peninsula, specifically the Persian Gulf region, shortly before proper Eurasians admixed with a Neanderthal population in a region stretching from the Levant to northern Iran.[4][5][6][7][8] Vallini et al. 2024 argues that the Basal Eurasian lineage diverged from other Eurasians soon after the Out-of-Africa migration, and subsequently became isolated, until it started to mix with other populations in the Middle East since around 25,000 years ago. These different Middle Eastern populations would later spread Basal Eurasian ancestry via the Neolithic Revolution to all of Western Eurasia.[9]

In modern populations, Neanderthal ancestry is around 10% to 20% lower in West Eurasians than East Eurasians, with intermediate levels found in South and Central Asian populations. Although a scenario involving multiple admixture events between modern humans and Neanderthals is an alternative possibility, the most likely explanation for this is that Neanderthal ancestry in West Eurasians and South and Central Asians was diluted by admixture with Basal Eurasian groups.[5]

Possible geographic origins

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The earliest evidence of Basal Eurasian ancestry is found in individuals from Dzudzuana Cave in Georgia dating to 26,000 years ago which have around 30% Basal Eurasian ancestry, with the rest being West Eurasian.[2]

Basal Eurasians may have originated in a region stretching from North Africa to the Middle East, before admixing with West-Eurasian populations.[4][5][6][7][8] North Africa has been described as a strong candidate for the location of the emergence of Basal Eurasians by Loosdrecht et al. in 2018.[10]

Ferreira et al. in 2021 argued for a point of origin for Basal Eurasians into the Middle East, specifically in the Persian Gulf region on the Arab peninsula. As Basal Eurasians had low levels of Neanderthal ancestry, genetic and archaeological evidence for interactions between modern humans and Neanderthals may allow certain areas, such as the Levant, to be ruled out as possible sources for Basal Eurasians. In other areas, such as southern Southwest Asia, there is currently no evidence for an overlap between modern human and Neanderthal populations.[7] Vallini et al. 2024 suggests a homeland for Basal Eurasians in the Arabian Peninsula, with a 'Common Eurasian Hub' in the Iranian Plateau, where they diverged into 'Ancient West Eurasians' and 'Ancient East Eurasians'.[9]

Estimated Basal Eurasian ancestry in ancient and modern populations

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Admixture graph model showing Basal Eurasian branch according to Allentoft et al. 2024
Phylogenetic position of Basal Eurasians in a wider Eurasian context[9]

An estimation for Holocene-era Near Easterners (e.g., Mesolithic Caucasus hunter-gatherers, Mesolithic and Neolithic Iranians, and Natufians) suggests that they formed from a combination of Basal Eurasian ancestry, and Western Hunter-Gatherer-related (WHG) and or Ancient North Eurasians-related (ANE) ancestries respectively.[10] The Mesolithic and Neolithic Iranian lineage is inferred to derived between 38–48% ancestry from Basal Eurasians respectively, with the remainder ancestry being made up by Ancient North Eurasian or Eastern Hunter-Gatherer (EHG) like ancestry, while Natufians derived a mean average of 50% Basal and 50% 'unknown hunter-gatherer' ancestry being closer to Western Hunter-Gatherers (WHG).[11][12][13][14] Alternatively, Mesolithic and Neolithic Iranians derive most of their ancestry from a deep West Eurasian source (WEC2; c. 72%) with c. 18% Basal Eurasian and c. 10% Ancient East Eurasian admixture.[15] It has been found that the "models of genetic history of West Asian human populations who are modeled as a mixture of ‘basal Eurasians’ and West European hunter–gatherers" is in agreement with the genomic data on 'East Mediterranean Dogs', who "are modeled as a mixture of a basal branch (splitting deeper than the divergence of the Asian and European dogs) and West European dogs".[16]

The Ancient North African Iberomaurusian (Taforalt) individuals were found to have harbored ~65% West Eurasian-like ancestry and considered likely direct descendants of such "Basal Eurasian" population. However they were shown to be genetically closer to Holocene-era Iranians and Levantine populations, which already harbored increased archaic (Neanderthal) admixture.[10]

Early European Farmers (EEFs), who had some Western European Hunter-Gatherer-related ancestry and originated in the Near East, also derive approximately 30% (to up to 44%) of their ancestry from this hypothetical Basal Eurasian lineage.[3][17] An Upper Paleolithic specimen from Kotias Klde cave in the Caucasus (Caucasus_25,000BP) had around 24% Basal Eurasian and 76% Upper Paleolithic European ancestry.[14]

Among modern populations, Basal-like ancestry peaks among Arabs (such as Qataris) at c. 45%, and among Iranian populations at c. 35%, and is also found in significant amounts among modern Northern Africans, in accordance with the high affinity towards the 'Arabian branch' of Eurasian diversity, which expanded into Northern and Northeastern Africa between 30 and 15 thousand years ago. Modern populations of the Levant derive between 35-38% ancestry from Basal Eurasians, modern Anatolians and populations from the Caucasus derive between 25-30% ancestry from Basal Eurasians, and modern Europeans derive around or less than 20% ancestry from Basal Eurasians.[7] Modern Bedouins and Yemenis are considered to represent direct descendants of the Basal Eurasians, carrying the highest amount of indigenous 'Arabian ancestry', and being basal to all modern Eurasian populations without displaying higher 'African-associated' admixture, and thus "are among the best genetic representatives of the autochthonous population on the Arabian Peninsula".[18]

References

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  1. ^ Quilodrán, Claudio S.; Rio, Jérémy; Tsoupas, Alexandros; Currat, Mathias (20 October 2023). "Past human expansions shaped the spatial pattern of Neanderthal ancestry". Science Advances. 9 (42): eadg9817. Bibcode:2023SciA....9G9817Q. doi:10.1126/sciadv.adg9817. ISSN 2375-2548. PMC 10584333. PMID 37851812.
  2. ^ a b Lazaridis, Iosif; Belfer-Cohen, Anna; Mallick, Swapan; Patterson, Nick; Cheronet, Olivia; Rohland, Nadin; Bar-Oz, Guy; Bar-Yosef, Ofer; Jakeli, Nino (21 September 2018), Paleolithic DNA from the Caucasus reveals core of West Eurasian ancestry, doi:10.1101/423079, retrieved 22 September 2024
  3. ^ a b Lazaridis et al. 2014.
  4. ^ a b Kamm et al. 2020.
  5. ^ a b c Bergström et al. 2021.
  6. ^ a b Vallini & Pagani 2022.
  7. ^ a b c d Ferreira et al. 2021.
  8. ^ a b Lazaridis et al. 2016.
  9. ^ a b c Vallini, Leonardo; Zampieri, Carlo; Shoaee, Mohamed Javad; Bortolini, Eugenio; Marciani, Giulia; Aneli, Serena; Pievani, Telmo; Benazzi, Stefano; Barausse, Alberto; Mezzavilla, Massimo; Petraglia, Michael D.; Pagani, Luca (25 March 2024). "The Persian plateau served as hub for Homo sapiens after the main out of Africa dispersal". Nature Communications. 15 (1): 1882. Bibcode:2024NatCo..15.1882V. doi:10.1038/s41467-024-46161-7. ISSN 2041-1723. PMC 10963722. PMID 38528002. The outlined scenario is complicated by the need to account for the Basal Eurasian population (Fig. 1A, green), a group30 that split from other Eurasians soon after the main Out of Africa expansion, hence also before the split between East and West Eurasians. This population was isolated from other Eurasians and later on, starting from at least ~25 kya31,32, admixed with populations from the Middle East. Their ancestry was subsequently carried by the population expansions associated with the Neolithic revolution to all of West Eurasia.
  10. ^ a b c van de Loosdrecht et al. 2018.
  11. ^ Lazaridis, Iosif; Nadel, Dani; Rollefson, Gary; Merrett, Deborah C.; Rohland, Nadin; Mallick, Swapan; Fernandes, Daniel; Novak, Mario; Gamarra, Beatriz; Sirak, Kendra; Connell, Sarah; Stewardson, Kristin; Harney, Eadaoin; Fu, Qiaomei; Gonzalez-Fortes, Gloria (August 2016). "Genomic insights into the origin of farming in the ancient Near East". Nature. 536 (7617): 419–424. Bibcode:2016Natur.536..419L. doi:10.1038/nature19310. ISSN 1476-4687. PMC 5003663. PMID 27459054. Neolithic Iran and Natufians could be derived from the same Basal Eurasian population but are genetically closer to EHG and WHG respectively. We take the model of Fig. S4.9 and attempt to fit Natufians as a mixture of the same Basal Eurasian population that contributes to Iran_N and any other population of the tree. Several solutions are feasible, and we show the best one (lowest ADMIXTUREGRAPH score) in Fig. S4.10. We can add both EHG and MA1 as simple branches to the model structure of Fig. S4.10 and show the results in Fig. S4.11. An interesting aspect of this model is that it derives both Natufians and Iran_N from Basal Eurasians but Natufians have ancestry from a population related to WHG, while Iran_N has ancestry related to EHG. Natufians and Iran_N may themselves reside on clines of WHG-related/EHG-related admixture.
  12. ^ Ferreira, Joana C; Alshamali, Farida; Montinaro, Francesco; Cavadas, Bruno; Torroni, Antonio; Pereira, Luisa; Raveane, Alessandro; Fernandes, Veronica (4 September 2021). "Projecting Ancient Ancestry in Modern-Day Arabians and Iranians: A Key Role of the Past Exposed Arabo-Persian Gulf on Human Migrations". Genome Biology and Evolution. 13 (9): evab194. doi:10.1093/gbe/evab194. ISSN 1759-6653. PMC 8435661. PMID 34480555. It has been previously speculated that isolated basal Eurasian lineage descendants in the central Zagros Mountains of Iran, who were the first goatherds, spread afterwards into the Eurasian steppe (Broushaki et al. 2016; Lazaridis et al. 2016). Also the ancient Iberomaurusian specimens could be in part descendants of basal Eurasians (van de Loosdrecht et al. 2018)
  13. ^ Almarri, Mohamed A.; Haber, Marc; Lootah, Reem A.; Hallast, Pille; Al Turki, Saeed; Martin, Hilary C.; Xue, Yali; Tyler-Smith, Chris (September 2021). "The genomic history of the Middle East". Cell. 184 (18): 4612–4625.e14. doi:10.1016/j.cell.2021.07.013. ISSN 0092-8674. PMC 8445022. PMID 34352227.
  14. ^ a b Allentoft, Morten E.; Sikora, Martin; Refoyo-Martínez, Alba; Irving-Pease, Evan K.; Fischer, Anders; Barrie, William; Ingason, Andrés; Stenderup, Jesper; Sjögren, Karl-Göran; Pearson, Alice; Sousa da Mota, Bárbara; Schulz Paulsson, Bettina; Halgren, Alma; Macleod, Ruairidh; Jørkov, Marie Louise Schjellerup (2024). "Population genomics of post-glacial western Eurasia". Nature. 625 (7994): 301–311. Bibcode:2024Natur.625..301A. doi:10.1038/s41586-023-06865-0. ISSN 0028-0836. PMC 10781627. PMID 38200295.
  15. ^ Vallini, Leonardo; Zampieri, Carlo; Shoaee, Mohamed Javad; Bortolini, Eugenio; Marciani, Giulia; Aneli, Serena; Pievani, Telmo; Benazzi, Stefano; Barausse, Alberto; Mezzavilla, Massimo; Petraglia, Michael D.; Pagani, Luca (25 March 2024). "The Persian plateau served as hub for Homo sapiens after the main out of Africa dispersal". Nature Communications. 15 (1): 1882. Bibcode:2024NatCo..15.1882V. doi:10.1038/s41467-024-46161-7. ISSN 2041-1723. PMC 10963722. PMID 38528002. Our results showed that the genetic component closest to the Hub population is represented in ancient and modern populations in the Persian Plateau. Such a component, after mixing with Basal and East Eurasian ancestries, resurfaced in the palaeogenetic record, previously referred to as the Iranian Neolithic, the Iranian Hunter Gatherer' or the East Meta49.
  16. ^ Maier, Robert; Flegontov, Pavel; Flegontova, Olga; Işıldak, Ulaş; Changmai, Piya; Reich, David (14 April 2023). Nordborg, Magnus; Przeworski, Molly; Balding, David; Wiuf, Carsten (eds.). "On the limits of fitting complex models of population history to f-statistics". eLife. 12: e85492. doi:10.7554/eLife.85492. ISSN 2050-084X. PMC 10310323. PMID 37057893. According to this model, East Mediterranean dogs are modeled as a mixture of a basal branch (splitting deeper than the divergence of the Asian and European dogs) and West European dogs, again in agreement with current models of genetic history of West Asian human populations who are modeled as a mixture of 'basal Eurasians' and West European hunter–gatherers (Lazaridis et al., 2016; Lipson et al., 2017).
  17. ^ Lipson, Mark; Szécsényi-Nagy, Anna; Mallick, Swapan; Pósa, Annamária; Stégmár, Balázs; Keerl, Victoria; Rohland, Nadin; Stewardson, Kristin; Ferry, Matthew; Michel, Megan; Oppenheimer, Jonas; Broomandkhoshbacht, Nasreen; Harney, Eadaoin; Nordenfelt, Susanne; Llamas, Bastien (November 2017). "Parallel palaeogenomic transects reveal complex genetic history of early European farmers". Nature. 551 (7680): 368–372. Bibcode:2017Natur.551..368L. doi:10.1038/nature24476. ISSN 1476-4687. PMC 5973800. PMID 29144465.
  18. ^ Rodriguez-Flores, Juan L.; Fakhro, Khalid; Agosto-Perez, Francisco; Ramstetter, Monica D.; Arbiza, Leonardo; Vincent, Thomas L.; Robay, Amal; Malek, Joel A.; Suhre, Karsten; Chouchane, Lotfi; Badii, Ramin; Al-Marri, Ajayeb Al-Nabet; Khalil, Charbel Abi; Zirie, Mahmoud; Jayyousi, Amin (1 February 2016). "Indigenous Arabs are descendants of the earliest split from ancient Eurasian populations". Genome Research. 26 (2): 151–162. doi:10.1101/gr.191478.115. ISSN 1088-9051. PMC 4728368. PMID 26728717. Given that the Q1 (Bedouin) have the greatest proportion of Arab genetic ancestry measured in contemporary populations (Hodgson et al. 2014; Shriner et al. 2014) and are among the best genetic representatives of the autochthonous population on the Arabian Peninsula, these two conclusions therefore point to the Bedouins being direct descendants of the earliest split after the out-of-Africa migration events that established a basal Eurasian population (Lazaridis et al. 2014). This is also consistent with the majority of Q1 (Bedouin) being able to trace a significant portion of their autosomal ancestry through lineages that never left the peninsula after the out-of-Africa migration events since such deep ancestry would not be expected if the entire Arabian Peninsula population had been reestablished from Africa or a non-African population at a later point.

Sources

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