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Exoribonuclease H

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Exoribonuclease H
Identifiers
EC no.3.1.13.2
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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NCBIproteins

Exoribonuclease H (EC 3.1.13.2) is an enzyme.[1] This enzyme catalyses the following chemical reaction

3'-end directed exonucleolytic cleavage of viral RNA-DNA hybrid

This is a secondary reaction to the RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end performed by EC 3.1.26.13 (retroviral ribonuclease H).

References

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  1. ^ Schatz O, Mous J, Le Grice SF (April 1990). "HIV-1 RT-associated ribonuclease H displays both endonuclease and 3'----5' exonuclease activity". The EMBO Journal. 9 (4): 1171–6. PMC 551793. PMID 1691093.
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