UHRF2

E3 ubiquitin-protein ligase UHRF2 is an enzyme that in humans is encoded by the UHRF2 gene.

UHRF2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WY8, 1Z6U, 2E6S, 3OLN, 4PW5, 4PW6, 4PW7, 4TVR
Identifiers
Aliases	UHRF2, NIRF, RNF107, URF2, TDRD23, ubiquitin like with PHD and ring finger domains 2
External IDs	OMIM: 615211; MGI: 1923718; HomoloGene: 17001; GeneCards: UHRF2; OMA:UHRF2 - orthologs
Gene location (Human) Chr. Chromosome 9 (human) Band 9p24.1 Start 6,413,151 bp End 6,507,054 bp
Gene location (Mouse) Chr. Chromosome 19 (mouse) Band 19|19 C1 Start 30,007,913 bp End 30,071,122 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte pancreatic epithelial cell Achilles tendon tibia thymus sperm ventricular zone germinal epithelium bone marrow bone marrow cells Top expressed in superior cervical ganglion hand tail of embryo ventricular zone genital tubercle primitive streak lens neural layer of retina epiblast thymus More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding histone binding protein binding metal ion binding ubiquitin protein ligase activity ubiquitin-protein transferase activity transferase activity SUMO transferase activity Cellular component nucleus nucleoplasm Biological process protein autoubiquitination regulation of DNA methylation-dependent heterochromatin assembly cell cycle cell differentiation cell population proliferation maintenance of DNA methylation protein ubiquitination regulation of cell cycle protein sumoylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 115426 109113 Ensembl ENSG00000147854 ENSMUSG00000024817 UniProt Q96PU4 Q7TMI3 RefSeq (mRNA) NM_152896 NM_152306 NM_144873 RefSeq (protein) NP_690856 NP_659122 Location (UCSC) Chr 9: 6.41 – 6.51 Mb Chr 19: 30.01 – 30.07 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis.

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Unoki M, Nishidate T, Nakamura Y (2004). "ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain". Oncogene. 23 (46): 7601–10. doi:10.1038/sj.onc.1208053. PMID 15361834. S2CID 21948278.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Li Y, Mori T, Hata H, et al. (2004). "NIRF induces G1 arrest and associates with Cdk2". Biochem. Biophys. Res. Commun. 319 (2): 464–8. doi:10.1016/j.bbrc.2004.04.190. PMID 15178429.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
• Mori T, Li Y, Hata H, Kochi H (2004). "NIRF is a ubiquitin ligase that is capable of ubiquitinating PCNP, a PEST-containing nuclear protein". FEBS Lett. 557 (1–3): 209–14. doi:10.1016/S0014-5793(03)01495-9. PMID 14741369. S2CID 10006213.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.