A tagging algorithm to identify jets that are significantly displaced from the proton-proton (pp) collision region in the CMS detector at the LHC is presented. Displaced jets can arise from the decays of long-lived particles (LLPs), which are predicted by several theoretical extensions of the standard model. The tagger is a multiclass classifier based on a deep neural network, which is parameterised according to the proper decay length $\mathrm{c}\tau_0$ of the LLP. A novel scheme is defined to reliably label jets from LLP decays for supervised learning. Samples of pp collision data, recorded by the CMS detector at a centre-of-mass energy of 13 TeV, and simulated events are used to train the neural network. Domain adaptation by backward propagation is performed to improve the simulation modelling of the jet class probability distributions observed in pp collision data. The potential performance of the tagger is demonstrated with a search for long-lived gluinos, a manifestation of split supersymmetric models. The tagger provides a rejection factor of 10 000 for jets from standard model processes, while maintaining an LLP jet tagging efficiency of 30-80% for gluinos with 1 mm $\leq$ $c\tau_0$ $\leq$ 10 m. The expected coverage of the parameter space for split supersymmetry is presented.

In July 2012, the ATLAS and CMS collaborations at the CERN Large Hadron Collider announced the observation of a Higgs boson at a mass of around 125 gigaelectronvolts. Ten years later, and with the data corresponding to the production of a 30-times larger number of Higgs bosons, we have learnt much more about the properties of the Higgs boson. The CMS experiment has observed the Higgs boson in numerous fermionic and bosonic decay channels, established its spin-parity quantum numbers, determined its mass and measured its production cross-sections in various modes. Here the CMS Collaboration reports the most up-to-date combination of results on the properties of the Higgs boson, including the most stringent limit on the cross-section for the production of a pair of Higgs bosons, on the basis of data from proton-proton collisions at a centre-of-mass energy of 13 teraelectronvolts. Within the uncertainties, all these observations are compatible with the predictions of the standard model of elementary particle physics. Much evidence points to the fact that the standard model is a low-energy approximation of a more comprehensive theory. Several of the standard model issues originate in the sector of Higgs boson physics. An order of magnitude larger number of Higgs bosons, expected to be examined over the next 15 years, will help deepen our understanding of this crucial sector.

Collinear (small-angle) and large-angle, as well as soft and hard radiations are investigated in three-jet and Z + two-jet events collected in proton-proton collisions at the LHC. The normalized production cross sections are measured as a function of the ratio of transverse momenta of two jets and their angular separation. The measurements in the three-jet and Z + two-jet events are based on data collected at a center-of-mass energy of 8 TeV, corresponding to an integrated luminosity of 19.8 fb$^{-1}$. The Z + two-jet events are reconstructed in the dimuon decay channel of the Z boson. The three-jet measurement is extended to include $\sqrt{s} =$ 13 TeV data corresponding to an integrated luminosity of 2.3 fb$^{-1}$. The results are compared to predictions from event generators that include parton showers, multiple parton interactions, and hadronization. The collinear and soft regions are in general well described by parton showers, whereas the regions of large angular separation are often best described by calculations using higher-order matrix elements.

Studies of $CP$ violation and anomalous couplings of the Higgs boson to vector bosons and fermions are presented. The data were acquired by the CMS experiment at the LHC and correspond to an integrated luminosity of 137 fb$^{-1}$ at a proton-proton collision energy of 13 TeV. The kinematic effects in the Higgs boson's four-lepton decay H $\to$ 4$\ell$ and its production in association with two jets, a vector boson, or top quarks are analyzed, using a full detector simulation and matrix element techniques to identify the production mechanisms and to increase sensitivity to the Higgs boson tensor structure of the Higgs boson interactions. A simultaneous measurement is performed of up to five Higgs boson couplings to electroweak vector bosons (HVV), two couplings to gluons (Hgg), and two couplings to top quarks (Htt). The $CP$ measurement in the Htt interaction is combined with the recent measurement in the H $\to$ $\gamma\gamma$ channel. The results are presented in the framework of anomalous couplings and are also interpreted in the framework of effective field theory, including the first study of $CP$ properties of the Htt and effective Hgg couplings from a simultaneous analysis of the gluon fusion and top-associated processes. The results are consistent with the standard model of particle physics.

The combination of polyphenols and probiotics offers a promising strategy for developing multifunctional solutions in health and nutrition. Polyphenols, renowned for their antioxidant and anti-inflammatory properties, and probiotics, acknowledged for their capacity to modulate gut microbiota, exhibit a synergistic relationship that can enhance the effectiveness of both components. This synergy arises from the ability of probiotics to metabolize polyphenols into bioactive compounds with improved bioavailability, while polyphenols contribute to a gut environment conducive to probiotic survival, growth, and activity. However, the effective delivery of these bioactive compounds and viable probiotics to specific gastrointestinal (GI) tract regions remains a critical challenge, limiting the impact of nutraceuticals and functional foods on health outcomes. This study aimed to develop a robust co-delivery system integrating a probiotic strain and a bioactive polyphenol using the innovative vacuum facilitated diffusion (VFD) technique. VFD has been proposed as a novel encapsulation method with the potential to protect bioactive compounds against harsh GI conditions and reduce exposure to intense manufacturing processes. Moreover, VFD may enhance microbial traits that support probiotic activity throughout the GI tract. Despite its potential, the capabilities and limitations of VFD require thorough investigation to advance the co-delivery system toward application trials. The research focused on constructing a co-delivery model using lactic acid bacteria strains from the Lactobacillaceae family, incorporating catechin as the phenolic compound. The study explored how VFD influences microbial metabolism, aiming to enhance probiotic functionality. To facilitate this analysis, a protocol for nuclear magnetic resonance (NMR) sample preparation using microbial biofluids was developed, allowing a deeper understanding of the metabolic mechanisms triggered by VFD in microbial cells. The Lactobacillus rhamnosus GG (LGG) strain was chosen for its potential to improve survival in the GI tract. Experiments were conducted in a controlled environment using MRS media to assess metabolic and growth behavior variations. Despite the promising hypothesis, the microbial assays and NMR analysis did not demonstrate significant changes attributable to the VFD process. The anticipated enhancements in probiotic persistence and survivability in the GI tract were not observed, limiting insights into the mechanisms underpinning the LGG + catechin co-delivery system. Nevertheless, the assays identified the vacuum application during VFD, rather than the presence of catechin or ethanol, as the primary factor contributing to decreased microbial viability. These findings suggest that further optimization of the VFD parameters is crucial to minimizing cellular stress and enhance the efficacy of the co-delivery system. Future studies should focus on refining the VFD process, exploring alternative probiotic strains, and evaluating the co-delivery system in dynamic GI models. The integration of polyphenols and probiotics through advanced techniques like VFD holds significant potential for advancing personalized nutrition and addressing complex health challenges in a sustainable and effective manner.

Abstract: The anisotropy of energetic particles provides essential information to help resolve the underlying fundamental physics of their spatial distributions, injection, acceleration, and transport processes. In this work, we report an energetic ion enhancement that is characterized by very large and long-lasting anisotropies observed by STEREO A and Solar Orbiter, which are nearly aligned along the same nominal Parker spiral. This ion enhancement appears at the rising phase of a widespread solar energetic particle event that was associated with the farside coronal mass ejection on 2022 February 15. According to our analysis, the long-lasting anisotropy resulted from the continuous injection of energetic ions from a well-connected particle source located beyond the STEREO A’s orbit. Solar Orbiter also observed an interval of very large anisotropy dominated exclusively by sunward streaming ions but with the additional implication that it detected the very early phase of ion injections onto magnetic field lines that newly connected to the particle source, which is likely the first reported event of this kind. These results further illustrate how energetic particle anisotropy information, in particular from multiple observer locations, can be used to disentangle the sources and transport processes of energetic ions, even when their heliospheric context is not simple.

The fast solar wind that fills the heliosphere originates from deep within regions of open magnetic field on the Sun called 'coronal holes'. The energy source responsible for accelerating the plasma is widely debated; however, there is evidence that it is ultimately magnetic in nature, with candidate mechanisms including wave heating^1,2 and interchange reconnection^3-5. The coronal magnetic field near the solar surface is structured on scales associated with 'supergranulation' convection cells, whereby descending flows create intense fields. The energy density in these 'network' magnetic field bundles is a candidate energy source for the wind. Here we report measurements of fast solar wind streams from the Parker Solar Probe (PSP) spacecraft⁶ that provide strong evidence for the interchange reconnection mechanism. We show that the supergranulation structure at the coronal base remains imprinted in the near-Sun solar wind, resulting in asymmetric patches of magnetic 'switchbacks'^7,8 and bursty wind streams with power-law-like energetic ion spectra to beyond 100 keV. Computer simulations of interchange reconnection support key features of the observations, including the ion spectra. Important characteristics of interchange reconnection in the low corona are inferred from the data, including that the reconnection is collisionless and that the energy release rate is sufficient to power the fast wind. In this scenario, magnetic reconnection is continuous and the wind is driven by both the resulting plasma pressure and the radial Alfvénic flow bursts.

NASA's Parker Solar Probe mission¹ recently plunged through the inner heliosphere of the Sun to its perihelia, about 24 million kilometres from the Sun. Previous studies farther from the Sun (performed mostly at a distance of 1 astronomical unit) indicate that solar energetic particles are accelerated from a few kiloelectronvolts up to near-relativistic energies via at least two processes: 'impulsive' events, which are usually associated with magnetic reconnection in solar flares and are typically enriched in electrons, helium-3 and heavier ions², and 'gradual' events^3,4, which are typically associated with large coronal-mass-ejection-driven shocks and compressions moving through the corona and inner solar wind and are the dominant source of protons with energies between 1 and 10 megaelectronvolts. However, some events show aspects of both processes and the electron-proton ratio is not bimodally distributed, as would be expected if there were only two possible processes⁵. These processes have been very difficult to resolve from prior observations, owing to the various transport effects that affect the energetic particle population en route to more distant spacecraft⁶. Here we report observations of the near-Sun energetic particle radiation environment over the first two orbits of the probe. We find a variety of energetic particle events accelerated both locally and remotely including by corotating interaction regions, impulsive events driven by acceleration near the Sun, and an event related to a coronal mass ejection. We provide direct observations of the energetic particle radiation environment in the region just above the corona of the Sun and directly explore the physics of particle acceleration and transport.