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Open Access Publications from the University of California

Scholarly Works (5 results)

  • Article
  • Peer Reviewed
UC Irvine Previously Published Works (2005)

Gastrointestinal ulcer healing is a complex process, involving cell migration, proliferation, angiogenesis and extracellular matrix deposition, all ultimately leading to reconstruction of tissue architecture within the ulcer scar. These processes are controlled by growth factors, cytokines and hormones. Transforming growth factor-beta (TGF-beta), one of the multifunctional peptide growth factors, has been reported to positively regulate gastrointestinal ulcer healing. Although TGF-beta inhibits cell proliferation in a variety of cells, it induces cell migration, angiogenesis, and enhances extracellular matrix production necessary for gastrointestinal ulcer healing. TGF-beta exerts its action by binding to its transmembrane serine/threonine kinase receptors, which in turn triggers activation of various intracellular signaling pathways. Smads are intermediate effector proteins that play key roles in biological activities of TGF-beta by transmitting the signals from the cell surface directly into the nucleus and initiating transcription. New insight into the mechanisms underlying TGF-beta-Smad modulation of gastrointestinal ulcer healing will likely enhance our understanding of the mechanisms controlling the healing processes of gastrointestinal ulcers.

    Cover page: TGF-beta signaling pathway: its role in gastrointestinal pathophysiology and modulation of ulcer healing.
    • Article
    • Peer Reviewed
    UC Irvine Previously Published Works (2002)
    Information about regional carbon sources and sinks can be derived from variations in observed atmospheric CO2 concentrations via inverse modelling with atmospheric tracer transport models. A consensus has not yet been reached regarding the size and distribution of regional carbon fluxes obtained using this approach, partly owing to the use of several different atmospheric transport models(1-9). Here we report estimates of surface- atmosphere CO2 fluxes from an intercomparison of atmospheric CO2 inversion models (the TransCom 3 project), which includes 16 transport models and model variants. We find an uptake of CO2 in the southern extratropical ocean less than that estimated from ocean measurements, a result that is not sensitive to transport models or methodological approaches. We also find a northern land carbon sink that is distributed relatively evenly among the continents of the Northern Hemisphere, but these results show some sensitivity to transport differences among models, especially in how they respond to seasonal terrestrial exchange of CO2. Overall, carbon fluxes integrated over latitudinal zones are strongly constrained by observations in the middle to high latitudes. Further significant constraints to our understanding of regional carbon fluxes will therefore require improvements in transport models and expansion of the CO2 observation network within the tropics.
      Cover page: Towards robust regional estimates of CO2 sources and sinks using atmospheric transport models
      • Article
      • Peer Reviewed
      Faculty Publications (2005)

      In TransCom-3 (Level 1), atmospheric CO2 measurements from 76 monitoring stations for the period 1992–1996 and 16 atmospheric transport models were used to constrain annual mean CO2 fluxes over 11 land and 11 ocean regions. The tower measurements of atmospheric CO2 from Fraserdale, a continental site in northern Ontario, Canada are now available and processed for use in the TransCom-3 inverse modelling framework. In this short study, we show that by including this set of continental CO2 data, the estimated flux for the North American boreal region becomes nearly zero, a reduction of about 0.26 Pg C yr−1 from the previous estimate. The uncertainty of the estimated flux for this region is also reduced by ∼30%. All transport models show negative changes for boreal North America, with the strongest responses (∼−0.5 Pg C yr−1) shown by NIRE, NIES, CSU and SKYHI. Furthermore, models showing a strong response in boreal North America tend to show strong sensitivity in middle- and high-latitude Asian regions.

        Cover page: Impact of Fraserdale CO 2 observations on annual flux inversion of the North American boreal region
        • Article
        • Peer Reviewed
        Faculty Publications (2002)
        This paper explores various sources of error in atmospheric CO2 synthesis inversions using global circulation models. The estimation of prior, observation, model transport, and representation errors is described, and the latter two error sources are explored in more detail. Not accounting for these errors will act as a hard constraint on the inversion and will produce incorrect solutions to the problem as is shown in some example inversions. The magnitude of these errors falls generally between about 10% and 100% in the retrieved fluxes but can be even larger. This makes it highly desirable to avoid hard constraints and apply any prior information we have about the surface fluxes as a weak constraint to the inversion problem.
          Cover page: On error estimation in atmospheric CO 2 inversions
          • Article
          • Peer Reviewed
          UC Davis Previously Published Works (2018)

          Background

          The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry.

          Methods and results

          A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up.

          Conclusion

          Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362.
            Cover page: Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry
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