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Open Access Publications from the University of California

Scholarly Works (10 results)

  • Peer Reviewed
Books and Book Chapters (2019)
We all believe in sustainability and work to be green as individuals, but there’s power insharing our knowledge and values and working together. Grow your sustainability efforts beyond single events by creating an advisory, education, and outreach group.
    Cover page: It Takes a Village Sustainability Starter
    • Peer Reviewed
    Books and Book Chapters (2019)
    A blueprint for hosting a free community swap. Watch trash become treasure as folks rummage through one another’s donated books, household items, andother goodies, taking what they want and giving what they don’t with absolutely no money involved. As an added bonus, items left over at the end of the day are donated to charity.
      Cover page: Absolutely Free Market
      • Peer Reviewed
      Books and Book Chapters (2019)
      Celebrate local food, community, and thebounty of harvest as library folks gather toshare fruits, vegetables, seeds, preserves, gardening and food publications, and their own knowledge. Promote sustainability and nurture a robust community by bringing coworkers together to share produce from their own gardens.
        Cover page: See How Our Garden Grows: Cultivating Community through a Fruit and Veggie Exchange
        • Peer Reviewed
        Books and Book Chapters (2019)
        Inspire users to actively engage with reducing, reusing, and recycling by hosting a DIY Makers’ Day. Chapter describes how to create this hands-on event that is jam-packed with DIY projects featuring creative reuse and sustainable ingredients. Participants leave with goodies they’ve made and recipes and instructions so they can continue creating at home. This is a great event for showcasing your library’s and community’s green resources.
          Cover page: DIY Makers' Day
          • Multimedia
          Presentations and Posters (2018)

          According to Maya Angelou, “the more you know of your history, the more liberated you are.” Knowledge of that history along with direct action organizing can oftentimes create significant change. In the academic environment, it can make students, particularly underrepresented students, aware of their own power in order to alter existing structures that don’t benefit or represent them. In April 2016, in response to political chalkings that targeted underrepresented students and the subsequent student discussions regarding the lack of support and representation on campus, the UC San Diego Library began Tell Us How UC It: A Living Archive. The purpose of this project is to provide the narrative of UC San Diego’s history of student activism to foster and contextualize a conversation about the ways students experience UC San Diego’s campus climate. The living archive format can be used to support, document, and engage social movements in any community by presenting an historical narrative, featuring community perspectives through all manner of creative work, and including in-the-moment feedback to the theme, event, or topic. The UC San Diego Library presented the project as a physical exhibit with accompanying events - workshops and classes, and an online collection using Omeka, a free and open-source platform. The development of the living archive required the expertise of and collaboration between multiple people and departments in the library and campus community. This poster will discuss the living archive concept, considerations for creating a living archive and digital exhibit, lessons learned, and the collaborations that were created from it.

          Presented at Joint Conference of Librarians of Color, Albuquerque, NM September 26-30, 2018.

          • 1 supplemental PDF
          • Book
          • Peer Reviewed
          UC San Diego Previously Published Works (2019)

          In 2019, the American Library Association added sustainability to its Core Values of Librarianship to foster community awareness and engagement on climate change, resilience, environmental impact, and a sustainable future. The Sustainable Library’s Cookbook collects a series of engaging activities for academic libraries interested in implementing sustainability practices in three different areas:

          Applying Sustainability Thinking and Development. Recipes are focused on applying sustainable thinking processes to library functions and services, including open educational resources, seed libraries, and reusable supplies and resources.Teaching, Learning, and Research Services. This section contains lesson plans, learning guides, research activities, and projects that focus on sustainability in disciplinary and interdisciplinary approaches, from STEM data literacy to campus sustainability projects to Indigenous environmental justice.Community Engagement, Outreach, and Partnerships. Recipes emphasize how community partnerships and outreach can be effective ways to inform and foster sustainability practices in the library and beyond, including environmental movie nights, bike-lending programs, and ideas for sustainable fashion.

          Many of these recipes include learning outcomes and goals from ACRL’s Framework for Information Literacy for Higher Education, disciplinary focuses, and the United Nations’ 2030 Sustainable Development Goals. This cookbook provides librarians with a series of best and effective practices, case studies, and approaches to support sustainability efforts in the library and collaboratively across campus.

            Cover page: I Believe You Have My Stapler: How to Encourage Reuse with an Office Supply Rehome Program
            • Article
            • Peer Reviewed
            UC San Francisco Previously Published Works (2013)

            Background

            IgE is both a marker and mediator of allergic inflammation. Despite reported differences in serum total IgE levels by race-ethnicity, African American and Latino subjects have not been well represented in genetic studies of total IgE.

            Objective

            We sought to identify the genetic predictors of serum total IgE levels.

            Methods

            We used genome-wide association data from 4292 subjects (2469 African Americans, 1564 European Americans, and 259 Latinos) in the EVE Asthma Genetics Consortium. Tests for association were performed within each cohort by race-ethnic group (ie, African American, Latino, and European American) and asthma status. The resulting P values were meta-analyzed, accounting for sample size and direction of effect. Top single nucleotide polymorphism associations from the meta-analysis were reassessed in 6 additional cohorts comprising 5767 subjects.

            Results

            We identified 10 unique regions in which the combined association statistic was associated with total serum IgE levels (P<5.0×10(-6)) and the minor allele frequency was 5% or greater in 2 or more population groups. Variant rs9469220, corresponding to HLA-DQB1, was the single nucleotide polymorphism most significantly associated with serum total IgE levels when assessed in both the replication cohorts and the discovery and replication sets combined (P=.007 and 2.45×10(-7), respectively). In addition, findings from earlier genome-wide association studies were also validated in the current meta-analysis.

            Conclusion

            This meta-analysis independently identified a variant near HLA-DQB1 as a predictor of total serum IgE levels in multiple race-ethnic groups. This study also extends and confirms the findings of earlier genome-wide association analyses in African American and Latino subjects.
              Cover page: A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations
              • Article
              • Peer Reviewed
              UC San Francisco Previously Published Works (2012)

              Background

              Genome-wide association studies of asthma have implicated many genetic risk factors, with well-replicated associations at approximately 10 loci that account for only a small proportion of the genetic risk.

              Objectives

              We aimed to identify additional asthma risk loci by performing an extensive replication study of the results from the EVE Consortium meta-analysis.

              Methods

              We selected 3186 single nucleotide polymorphisms for replication based on the P values from the EVE Consortium meta-analysis. These single nucleotide polymorphisms were genotyped in ethnically diverse replication samples from 9 different studies, totaling 7202 cases, 6426 controls, and 507 case-parent trios. Association analyses were conducted within each participating study, and the resulting test statistics were combined in a meta-analysis.

              Results

              Two novel associations were replicated in European Americans: rs1061477 in the KLK3 gene on chromosome 19 (combined odds ratio = 1.18; 95% CI, 1.10-1.25) and rs9570077 (combined odds ratio =1.20; 95% CI, 1.12-1.29) on chromosome 13q21. We could not replicate any additional associations in the African Americans or Latinos.

              Conclusions

              This extended replication study identified 2 additional asthma risk loci in populations of European descent. The absence of additional loci for African Americans and Latinos highlights the difficulty in replicating associations in admixed populations.
                Cover page: Further replication studies of the EVE Consortium meta-analysis identifies 2 asthma risk loci in European Americans
                • Article
                • Peer Reviewed
                UC San Francisco Previously Published Works (2014)
                Asthma is a complex disease with sex-specific differences in prevalence. Candidate gene studies have suggested that genotype-by-sex interaction effects on asthma risk exist, but this has not yet been explored at a genome-wide level. We aimed to identify sex-specific asthma risk alleles by performing a genome-wide scan for genotype-by-sex interactions in the ethnically diverse participants in the EVE Asthma Genetics Consortium. We performed male- and female-specific genome-wide association studies in 2653 male asthma cases, 2566 female asthma cases and 3830 non-asthma controls from European American, African American, African Caribbean and Latino populations. Association tests were conducted in each study sample, and the results were combined in ancestry-specific and cross-ancestry meta-analyses. Six sex-specific asthma risk loci had P-values < 1 × 10(-6), of which two were male specific and four were female specific; all were ancestry specific. The most significant sex-specific association in European Americans was at the interferon regulatory factor 1 (IRF1) locus on 5q31.1. We also identify a Latino female-specific association in RAP1GAP2. Both of these loci included single-nucleotide polymorphisms that are known expression quantitative trait loci and have been associated with asthma in independent studies. The IRF1 locus is a strong candidate region for male-specific asthma susceptibility due to the association and validation we demonstrate here, the known role of IRF1 in asthma-relevant immune pathways and prior reports of sex-specific differences in interferon responses.
                  Cover page: Genome-wide interaction studies reveal sex-specific asthma risk alleles
                  • Article
                  • Peer Reviewed
                  UC San Francisco Previously Published Works (2018)
                  Allergic rhinitis is the most common clinical presentation of allergy, affecting 400 million people worldwide, with increasing incidence in westernized countries1,2. To elucidate the genetic architecture and understand the underlying disease mechanisms, we carried out a meta-analysis of allergic rhinitis in 59,762 cases and 152,358 controls of European ancestry and identified a total of 41 risk loci for allergic rhinitis, including 20 loci not previously associated with allergic rhinitis, which were confirmed in a replication phase of 60,720 cases and 618,527 controls. Functional annotation implicated genes involved in various immune pathways, and fine mapping of the HLA region suggested amino acid variants important for antigen binding. We further performed genome-wide association study (GWAS) analyses of allergic sensitization against inhalant allergens and nonallergic rhinitis, which suggested shared genetic mechanisms across rhinitis-related traits. Future studies of the identified loci and genes might identify novel targets for treatment and prevention of allergic rhinitis.
                    Cover page: Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis
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