Transxelina
| PDB 1ujo | |
Transxelina
| |
| Identificadores | |
| Símbolo | TAGLN |
| Símbolos alt. | SM22; SMCC; TAGLN1; WS3-10 |
| Entrez | 6876 |
| OMIM | |
| RefSeq | NP_001001522 |
| UniProt | Q01995 |
| Outros datos | |
| Locus | Cr. 11 117.07 – 117.08 Mb |
A transxelina (TAGLN) é unha proteína que nos humanos está codificada polo xene TAGLN do cromosoma 11.[1][2][3]
A proteína transxelina é unha proteína xelificante/creadora de pontes cruzadas coa actina sensible aos cambios de forma celulares e ás transformacións (como as producidas nas células mesenquimais por virus ou por cambiar a condicións de cultivo non adherentes), que se encontra nos fibroblastos e no músculo liso. A súa expresión está regulada á baixa en moitas liñas celulares, e está regulación á baixa pode ser un marcador sensible e temperán para o comezo da transformación. Ao feito de que produza xeles e sexa sensible ás transformacións débese o seu nome (trans-xel-ina). O papel funcional desta proteína non está claro. Neste xene atopáronse dous transcritos variantes que codifican a mesma proteína.[3] A transxelina ten un peso molecular de 22 kDa e ten unha similitude estrutural coa calponina.
Notas
[editar | editar a fonte]- ↑ Kobayashi R, Kubota T, Hidaka H (Mar 1994). "Purification, characterization, and partial sequence analysis of a new 25-kDa actin-binding protein from bovine aorta: a SM22 homolog". Biochem Biophys Res Commun 198 (3): 1275–80. PMID 8117285. doi:10.1006/bbrc.1994.1180.
- ↑ Thweatt R, Lumpkin CK Jr, Goldstein S (Oct 1992). "A novel gene encoding a smooth muscle protein is overexpressed in senescent human fibroblasts". Biochem Biophys Res Commun 187 (1): 1–7. PMID 1520290. doi:10.1016/S0006-291X(05)81449-4.
- ↑ 3,0 3,1 "Entrez Gene: TAGLN transgelin".
Véxase tamén
[editar | editar a fonte]Outros artigos
[editar | editar a fonte]Bibliografía
[editar | editar a fonte]- Nishida W, Kitami Y, Abe M, Hiwada K (1991). "Gene cloning and nucleotide sequence of SM22 alpha from the chicken gizzard smooth muscle". Biochem. Int. 23 (4): 663–8. PMID 1872880.
- Nagase T, Miyajima N, Tanaka A; et al. (1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (1): 37–43. PMID 7788527. doi:10.1093/dnares/2.1.37.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. PMID 8125298. doi:10.1016/0378-1119(94)90802-8.
- Li L, Liu Z, Mercer B; et al. (1997). "Evidence for serum response factor-mediated regulatory networks governing SM22alpha transcription in smooth, skeletal, and cardiac muscle cells". Dev. Biol. 187 (2): 311–21. PMID 9242426. doi:10.1006/dbio.1997.8621.
- Yamamura H, Masuda H, Ikeda W; et al. (1997). "Structure and expression of the human SM22alpha gene, assignment of the gene to chromosome 11, and repression of the promoter activity by cytosine DNA methylation". J. Biochem. 122 (1): 157–67. PMID 9276683. doi:10.1093/oxfordjournals.jbchem.a021722.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. PMID 9373149. doi:10.1016/S0378-1119(97)00411-3.
- Lawson D, Harrison M, Shapland C (1998). "Fibroblast transgelin and smooth muscle SM22alpha are the same protein, the expression of which is down-regulated in many cell lines". Cell Motil. Cytoskeleton 38 (3): 250–7. PMID 9384215. doi:10.1002/(SICI)1097-0169(1997)38:3<250::AID-CM3>3.0.CO;2-9.
- Camoretti-Mercado B, Forsythe SM, LeBeau MM; et al. (1998). "Expression and cytogenetic localization of the human SM22 gene (TAGLN)". Genomics 49 (3): 452–7. PMID 9615232. doi:10.1006/geno.1998.5267.
- Fu Y, Liu HW, Forsythe SM; et al. (2001). "Mutagenesis analysis of human SM22: characterization of actin binding". J. Appl. Physiol. 89 (5): 1985–90. PMID 11053353.
- Shields JM, Rogers-Graham K, Der CJ (2002). "Loss of transgelin in breast and colon tumors and in RIE-1 cells by Ras deregulation of gene expression through Raf-independent pathways". J. Biol. Chem. 277 (12): 9790–9. PMID 11773051. doi:10.1074/jbc.M110086200.
- Chainiaux F, Magalhaes JP, Eliaers F; et al. (2002). "UVB-induced premature senescence of human diploid skin fibroblasts". Int. J. Biochem. Cell Biol. 34 (11): 1331–9. PMID 12200029. doi:10.1016/S1357-2725(02)00022-5.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899.
- Xu R, Ho YS, Ritchie RP, Li L (2003). "Human SM22 alpha BAC encompasses regulatory sequences for expression in vascular and visceral smooth muscles at fetal and adult stages". Am. J. Physiol. Heart Circ. Physiol. 284 (4): H1398–407. PMID 12521938. doi:10.1152/ajpheart.00737.2002.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. PMC 528928. PMID 15489334. doi:10.1101/gr.2596504.
- Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. PMID 16189514. doi:10.1038/nature04209.
- Yang Z, Chang YJ, Miyamoto H; et al. (2007). "Transgelin functions as a suppressor via inhibition of ARA54-enhanced androgen receptor transactivation and prostate cancer cell growth". Mol. Endocrinol. 21 (2): 343–58. PMID 17082327. doi:10.1210/me.2006-0104.
- Liao X, Li S, Lou Z; et al. (2007). "Crystallization and preliminary crystallographic analysis of transgelin". Protein Pept. Lett. 14 (2): 209–11. PMID 17305610. doi:10.2174/092986607779816122.
- Ewing RM, Chu P, Elisma F; et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. PMC 1847948. PMID 17353931. doi:10.1038/msb4100134.