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  1. Neurodegenerative diseases, including Alzheimer’s Disease (AD) and Parkinson’s Disease (PD) are common complications of diabetes, arising from insulin resistance, inflammation, and other pathological processes...

    Authors: Chien-Tai Hong, Jia-Hung Chen and Chaur-Jong Hu
    Citation: Journal of Biomedical Science 2024 31:102
    Content type: Review Published on:

  2. A variety of cell death pathways play critical roles in the onset and progression of multiple diseases. Paraptosis, a unique form of programmed cell death, has gained significant attention in recent years. Unl...

    Authors: Ling-Chu Chang, Shih-Kai Chiang, Shuen-Ei Chen and Mien-Chie Hung
    Citation: Journal of Biomedical Science 2024 31:101
    Content type: Review Published on:

  3. Alveolar capillary dysplasia with misalignment of pulmonary veins (ACD/MPV) is a fatal congenital lung disorder strongly associated with genomic alterations in the Forkhead box F1 (FOXF1) gene and its regulato...

    Authors: G. G. Edel, M. van Kempen, A. Boerema-de Munck, C. N. Huisman, C. A. P. Naalden, R. W. W. Brouwer, S. Koornneef, W. F. J. van IJcken, R. M. H. Wijnen and R. J. Rottier
    Citation: Journal of Biomedical Science 2024 31:100
    Content type: Research Published on:

  4. Cell therapy has emerged as a revolutionary tool to repair damaged tissues by restoration of an adequate vasculature. Dental Pulp stem cells (DPSC), due to their easy biological access, ex vivo properties, and...

    Authors: Ludovica Barone, Martina Cucchiara, Maria Teresa Palano, Barbara Bassani, Matteo Gallazzi, Federica Rossi, Mario Raspanti, Piero Antonio Zecca, Gianluca De Antoni, Christina Pagiatakis, Roberto Papait, Giovanni Bernardini, Antonino Bruno and Rosalba Gornati
    Citation: Journal of Biomedical Science 2024 31:99
    Content type: Research Published on:

  5. Extracellular vesicles (EVs) are cell-secreted particles conceived as natural vehicles for intercellular communication. The capacity to entrap heterogeneous molecular cargoes and target specific cell populatio...

    Authors: Elena Gurrieri, Giulia Carradori, Michela Roccuzzo, Michael Pancher, Daniele Peroni, Romina Belli, Caterina Trevisan, Michela Notarangelo, Wen-Qiu Huang, Agata S. A. Carreira, Alessandro Quattrone, Guido Jenster, Timo L. M. Ten Hagen and Vito Giuseppe D’Agostino
    Citation: Journal of Biomedical Science 2024 31:92
    Content type: Research Published on:

  6. Primary ovarian insufficiency (POI) is an early decline in ovarian function that leads to ovarian failure. Conventional treatments for POI are inadequate, and treatments based on mesenchymal stem cells (MSCs) ...

    Authors: Duy-Cuong Le, Mai-Huong T. Ngo, Yung-Che Kuo, Shu-Hwa Chen, Chung-Yen Lin, Thai-Yen Ling, Quoc Thao Trang Pham, Heng-Kien Au, Jihwan Myung and Yen-Hua Huang
    Citation: Journal of Biomedical Science 2024 31:95
    Content type: Research Published on:

  7. Recent breakthroughs in cancer immunotherapies have emphasized the importance of harnessing the immune system for treating cancer. Vaccines, which have traditionally been used to promote protective immunity ag...

    Authors: Wei-Yu Chi, Yingying Hu, Hsin-Che Huang, Hui-Hsuan Kuo, Shu-Hong Lin, Chun-Tien Jimmy Kuo, Julia Tao, Darrell Fan, Yi-Min Huang, Annie A. Wu, Chien-Fu Hung and T.-C. Wu
    Citation: Journal of Biomedical Science 2024 31:94
    Content type: Review Published on:

  9. Recent advances in studies exploring the roles of extracellular vesicles (EVs) in viral transmission and replication have illuminated hepatotropic viruses, such as hepatitis A (HAV), hepatitis B (HBV), hepatit...

    Authors: Yu-De Chu, Mi-Chi Chen, Chau-Ting Yeh and Ming-Wei Lai
    Citation: Journal of Biomedical Science 2024 31:97
    Content type: Review Published on:

  10. Triple-negative breast cancer (TNBC), characterized by high invasiveness, is associated with poor prognosis and elevated mortality rates. Despite the development of effective therapeutic targets for TNBC, syst...

    Authors: Maria Vitoria Tofolo, Fernanda Costa Brandão Berti, Emanuelle Nunes-Souza, Mayara Oliveira Ruthes, Lucas Freitas Berti, Aline Simoneti Fonseca, Daiane Rosolen and Luciane Regina Cavalli
    Citation: Journal of Biomedical Science 2024 31:93
    Content type: Review Published on:

  11. Over the past decade, organoids have emerged as a prevalent and promising research tool, mirroring the physiological architecture of the human body. However, as the field advances, the traditional use of anima...

    Authors: Chen Li, Ni An, Qingru Song, Yuelei Hu, Wenzhen Yin, Qi Wang, Yinpeng Le, Wenting Pan, Xinlong Yan, Yunfang Wang and Juan Liu
    Citation: Journal of Biomedical Science 2024 31:96
    Content type: Review Published on:

  12. Traumatic brain injury (TBI) causes axon tearing and synapse degradation, resulting in multiple neurological dysfunctions and exacerbation of early neurodegeneration; the repair of axonal and synaptic structur...

    Authors: Man-Hau Ho, Yih-Jeng Tsai, Chia-Yen Chen, Anastasia Yang, Thierry Burnouf, Yun Wang, Yung-Hsiao Chiang, Barry J. Hoffer and Szu-Yi Chou
    Citation: Journal of Biomedical Science 2024 31:91
    Content type: Research Published on:

  13. Stromal fibrosis is highly associated with therapeutic resistance and poor survival in esophageal squamous cell carcinoma (ESCC) patients. Low expression of plasma gelsolin (pGSN), a serum abundant protein, ha...

    Authors: Chih-Hsiung Hsieh, Pei-Shiuan Ho, Wen-Lun Wang, Fu-Hsuan Shih, Chen-Tai Hong, Pei-Wen Wang, Dar-Bin Shieh, Wei-Lun Chang and Yi-Ching Wang
    Citation: Journal of Biomedical Science 2024 31:90
    Content type: Research Published on:

  14. Realizing the immense clinical potential of mRNA-based drugs will require continued development of methods to safely deliver the bioactive agents with high efficiency and without triggering side effects. In th...

    Authors: Ruei-Min Lu, Hsiang-En Hsu, Ser John Lynon P. Perez, Monika Kumari, Guan-Hong Chen, Ming-Hsiang Hong, Yin-Shiou Lin, Ching-Hang Liu, Shih-Han Ko, Christian Angelo P. Concio, Yi-Jen Su, Yi-Han Chang, Wen-Shan Li and Han-Chung Wu
    Citation: Journal of Biomedical Science 2024 31:89
    Content type: Review Published on:

  15. Dysregulation of vascular homeostasis can induce cardiovascular diseases and increase global mortality rates. Although lineage tracing studies have confirmed the pivotal role of modulated vascular smooth muscl...

    Authors: Yichen Wu, Zilong Chen, Zhe Zheng, Xiaoguang Li, Jiangcheng Shu, Ruiqi Mao, Jie An, Siyuan Fan, Ruijie Luo, Yi Guo, Wenjing Xu, Minglu Liang, Kai Huang and Cheng Wang
    Citation: Journal of Biomedical Science 2024 31:88
    Content type: Research Published on:

  16. The burgeoning field of regenerative medicine has significantly advanced with recent findings on biotherapies using human platelet lysates (HPLs), derived from clinical-grade platelet concentrates (PCs), for t...

    Authors: Liling Delila, Ouada Nebie, Nhi Thao Ngoc Le, Kelly Timmerman, Deng-Yao Lee, Yu-Wen Wu, Ming-Li Chou, Luc Buée, Szu-Yi Chou, David Blum, David Devos and Thierry Burnouf
    Citation: Journal of Biomedical Science 2024 31:87
    Content type: Research Published on:

  17. While dengue NS1 antigen has been shown to be associated with disease pathogenesis in some studies, it has not been linked in other studies, with the reasons remaining unclear. NS1 antigen levels in acute deng...

    Authors: Shashika Dayarathna, Bhagya Senadheera, Chandima Jeewandara, Madushika Dissanayake, Farha Bary, Graham S. Ogg and Gathsaurie Neelika Malavige
    Citation: Journal of Biomedical Science 2024 31:86
    Content type: Research Published on:

  18. Extracellular vesicles (EVs) are vital for cell-to-cell communication, transferring proteins, lipids, and nucleic acids in various physiological and pathological processes. They play crucial roles in immune mo...

    Authors: Napasiri Putthanbut, Jea Young Lee and Cesario V. Borlongan
    Citation: Journal of Biomedical Science 2024 31:85
    Content type: Review Published on:

  19. Identification of lung cancer subtypes is critical for successful treatment in patients, especially those in advanced stages. Many advanced and personal treatments require knowledge of specific mutations, as w...

    Authors: Adam Germain, Alex Sabol, Anjani Chavali, Giles Fitzwilliams, Alexa Cooper, Sandra Khuon, Bailey Green, Calvin Kong, John Minna and Young-Tae Kim
    Citation: Journal of Biomedical Science 2024 31:84
    Content type: Research Published on:

  20. Human immunodeficiency virus type 1 (HIV-1) vaccine immunogens capable of inducing broadly neutralizing antibodies (bNAbs) remain obscure. HIV-1 evades immune responses through enormous diversity and hides its...

    Authors: Stephen Ian Walimbwa, Petr Maly, Leona Raskova Kafkova and Milan Raska
    Citation: Journal of Biomedical Science 2024 31:83
    Content type: Review Published on:

  21. Intracellular sensing of lipopolysaccharide (LPS) is essential for the immune response against gram-negative bacteria and results in activation of caspase-11 and pyroptotic cell death with fatal consequences i...

    Authors: Alice Bernard, Claudia Eggstein, Linyan Tang, Marius Keller, Andreas Körner, Valbona Mirakaj and Peter Rosenberger
    Citation: Journal of Biomedical Science 2024 31:82
    Content type: Research Published on:

  22. Betulinic acid (BA) has been well investigated for its antiproliferative and mitochondrial pathway-mediated apoptosis-inducing effects on various cancers. However, its poor solubility and off-target activity h...

    Authors: Debasmita Dutta, Ashique Al Hoque, Brahamacharry Paul, Jun Hyoung Park, Chinmay Chowdhury, Mohiuddin Quadir, Soumyabrata Banerjee, Arghadip Choudhury, Soumik Laha, Nayim Sepay, Priyanka Boro, Benny Abraham Kaipparettu and Biswajit Mukherjee
    Citation: Journal of Biomedical Science 2024 31:81
    Content type: Research Published on:

  23. Around 10% of people with HIV (PWH) exhibit a low-level viremia (LLV) under antiretroviral therapy (ART). However, its origin and clinical significance are largely unknown, particularly at viremias between 50 ...

    Authors: Violeta Lara-Aguilar, Manuel Llamas-Adán, Óscar Brochado-Kith, Celia Crespo-Bermejo, Sergio Grande-García, Sonia Arca-Lafuente, Ignacio de los Santos, Carmen Prado, Mario Alía, Coral Sainz-Pinós, Amanda Fernández-Rodríguez, Luz Martín-Carbonero, Ricardo Madrid and Verónica Briz
    Citation: Journal of Biomedical Science 2024 31:80
    Content type: Research Published on:

  25. Helicobacter pylori infection is involved in gastric diseases such as peptic ulcer and adenocarcinoma. Approved antibiotherapies still fail in 10 to 40% of the infected patients and, in this scenario, targeted na...

    Authors: Rute Chitas, Diana R. Fonseca, Paula Parreira and M. Cristina L. Martins
    Citation: Journal of Biomedical Science 2024 31:78
    Content type: Review Published on:

  26. Dectin-1 is a transmembrane receptor that plays a pivotal role in recognising fungi and Mycobacterium tuberculosis (Mtb). A specific variant, DECTIN-1 rs16910526, results in a truncated receptor that disrupts mem...

    Authors: Mónica Cufré, Mercedes Pastorini, Ignacio Martín, Rodrigo Failde, Domingo Palmero and Mercedes Alemán
    Citation: Journal of Biomedical Science 2024 31:77
    Content type: Research Published on:

  27. Authors: Letteria Minutoli, Domenica Altavilla, Herbert Marini, Mariagrazia Rinaldi, Natasha Irrera, Gabriele Pizzino, Alessandra Bitto, Salvatore Arena, Sebastiano Cimino, Francesco Squadrito, Giorgio Ivan Russo and Giuseppe Morgia
    Citation: Journal of Biomedical Science 2024 31:76
    Content type: Retraction Note Published on:

  28. Among the non-traditional antibacterial agents in development, only a few targets critical Gram-negative bacteria such as carbapenem-resistant Pseudomonas aeruginosa, Acinetobacter baumannii or cephalosporin-resi...

    Authors: Daria V. Vasina, Nataliia P. Antonova, Vladimir A. Gushchin, Andrey V. Aleshkin, Mikhail V. Fursov, Anastasiia D. Fursova, Petya G. Gancheva, Igor V. Grigoriev, Pavel Grinkevich, Alexey V. Kondratev, Alexey V. Kostarnoy, Anastasiya M. Lendel, Valentine V. Makarov, Maria A. Nikiforova, Andrei A. Pochtovyi, Tatiana Prudnikova…
    Citation: Journal of Biomedical Science 2024 31:75
    Content type: Research Published on:

  29. Prostate cancer (PrCa) is the most frequently diagnosed cancer in men. Variants in known moderate- to high-penetrance genes explain less than 5% of the cases arising at early-onset (< 56 years) and/or with fam...

    Authors: Maria P. Silva, Luísa T. Ferreira, Natércia F. Brás, Lurdes Torres, Andreia Brandão, Manuela Pinheiro, Marta Cardoso, Adriana Resende, Joana Vieira, Carlos Palmeira, Gabriela Martins, Miguel Silva, Carla Pinto, Ana Peixoto, João Silva, Rui Henrique…
    Citation: Journal of Biomedical Science 2024 31:74
    Content type: Research Published on:

  31. Epithelial cell adhesion molecule (EpCAM) has been widely studied as a tumor antigen due to its expression in varieties of solid tumors. Moreover, the glycoprotein contributes to critical cancer-associated cel...

    Authors: Sushree Shankar Panda, Chi-Chiu Lee, Khamushavalli Geevimaan, Kai-Chi Chen, Shung-Haur Yang, Chia-Ning Shen, Wei-Chun HuangFu and Han-Chung Wu
    Citation: Journal of Biomedical Science 2024 31:72
    Content type: Research Published on:

  32. Critical limb-threatening ischemia (CLTI) constitutes the most severe manifestation of peripheral artery disease, usually induced by atherosclerosis. CLTI patients suffer from high risk of amputation of the lo...

    Authors: Marta Rojas-Torres, Lucía Beltrán-Camacho, Ana Martínez-Val, Ismael Sánchez-Gomar, Sara Eslava-Alcón, Antonio Rosal-Vela, Margarita Jiménez-Palomares, Esther Doiz-Artázcoz, Mario Martínez-Torija, Rafael Moreno-Luna, Jesper V. Olsen and Ma. Carmen Duran-Ruiz
    Citation: Journal of Biomedical Science 2024 31:71
    Content type: Research Published on:

  33. Coronaviruses employ various strategies for survival, among which the activation of endogenous or exogenous apoptosis stands out, with viral proteins playing a pivotal role. Notably, highly pathogenic coronavi...

    Authors: Leyi Cheng, Yajuan Rui, Yanpu Wang, Shiqi Chen, Jiaming Su and Xiao-Fang Yu
    Citation: Journal of Biomedical Science 2024 31:70
    Content type: Review Published on:

  34. Local translation at synapses is important for rapidly remodeling the synaptic proteome to sustain long-term plasticity and memory. While the regulatory mechanisms underlying memory-associated local translatio...

    Authors: Wen-Hsin Lu, Tzu-Tung Chang, Yao-Ming Chang, Yi-Hsiang Liu, Chia-Hsuan Lin, Ching-Shu Suen, Ming-Jing Hwang and Yi-Shuian Huang
    Citation: Journal of Biomedical Science 2024 31:69
    Content type: Research Published on:

  35. KRAS mutations frequently occur in cancers, particularly pancreatic ductal adenocarcinoma, colorectal cancer, and non-small cell lung cancer. Although KRASG12C inhibitors have recently been approved, effective pr...

    Authors: Hiroshi Kotani, Hiroko Oshima, Justin C. Boucher, Tomoyoshi Yamano, Hiroyuki Sakaguchi, Shigeki Sato, Koji Fukuda, Akihiro Nishiyama, Kaname Yamashita, Koushiro Ohtsubo, Shinji Takeuchi, Takumi Nishiuchi, Masanobu Oshima, Marco L. Davila and Seiji Yano
    Citation: Journal of Biomedical Science 2024 31:68
    Content type: Research Published on:

  36. Exosomes are extracellular vesicles generated by all cells and they carry nucleic acids, proteins, lipids, and metabolites. They mediate the exchange of substances between cells,thereby affecting biological pr...

    Authors: Yi-Fan Chen, Frank Luh, Yuan-Soon Ho and Yun Yen
    Citation: Journal of Biomedical Science 2024 31:67
    Content type: Review Published on:

  37. Cholestasis is a common yet severe complication that occurs during the advancement of liver metastasis. However, how cholestasis impacts the development, treatment, and tumor microenvironment (TME) of liver me...

    Authors: Li Sun, Nanyan Yang, Zhihong Liu, Xiandong Ye, Mengting Cheng, Lingjun Deng, Junhao Zhang, Jingjing Wu, Min Shi and Wangjun Liao
    Citation: Journal of Biomedical Science 2024 31:66
    Content type: Research Published on:

  38. Enterovirus 71 (EV-A71) causes Hand, Foot and Mouth Disease (HFMD) in children and has been associated with neurological complications. The molecular mechanisms involved in EV-A71 pathogenesis have remained el...

    Authors: Qing Yong Ng, Vikneswari Mahendran, Ze Qin Lim, Jasmine Hwee Yee Tan, Joel Jie Feng Wong, Justin Jang Hann Chu, Vincent T. K. Chow, Newman Siu Kwan Sze and Sylvie Alonso
    Citation: Journal of Biomedical Science 2024 31:65
    Content type: Research Published on:

  39. The endoplasmic reticulum (ER) employs stringent quality control mechanisms to ensure the integrity of protein folding, allowing only properly folded, processed and assembled proteins to exit the ER and reach ...

    Authors: Nesrin Gariballa, Feda Mohamed, Sally Badawi and Bassam R. Ali
    Citation: Journal of Biomedical Science 2024 31:64
    Content type: Review Published on:

  41. Ovarian carcinoma (OC) is a fatal malignancy, with most patients experiencing recurrence and resistance to chemotherapy. In contrast to hematogenous metastasizing tumors, ovarian cancer cells disseminate withi...

    Authors: Chang-Ni Lin, Yu-Ling Liang, Hsing-Fen Tsai, Pei-Ying Wu, Lan-Yin Huang, Yu-Han Lin, Chieh-Yi Kang, Chao-Ling Yao, Meng-Ru Shen and Keng-Fu Hsu
    Citation: Journal of Biomedical Science 2024 31:62
    Content type: Research Published on:

  42. Authors: B. Linju Yen, Li‑Tzu Wang, Hsiu‑Huang Wang, Chin‑Pao Hung, Pei‑Ju Hsu, Chia‑Chi Chang, Chien‑Yu Liao, Huey‑Kang Sytwu and Men‑Luh Yen
    Citation: Journal of Biomedical Science 2024 31:61
    Content type: Correction Published on:

    The original article was published in Journal of Biomedical Science 2024 31:49

  43. Flavivirus is a challenge all over the world. The replication of flavivirus takes place within membranous replication compartments (RCs) derived from endoplasmic reticulum (ER). Flavivirus NS1 proteins have be...

    Authors: Shuhan Huang, Pan-Deng Shi, Xiao-Xuan Fan, Yang Yang, Cheng-Feng Qin, Hui Zhao, Lei Shi and Yali Ci
    Citation: Journal of Biomedical Science 2024 31:60
    Content type: Research Published on:

  44. Osteosarcoma (OS) is the most prevalent and fatal type of bone tumor. It is characterized by great heterogeneity of genomic aberrations, mutated genes, and cell types contribution, making therapy and patients ...

    Authors: Nicola Mosca, Nicola Alessio, Alessandra Di Paola, Maria Maddalena Marrapodi, Umberto Galderisi, Aniello Russo, Francesca Rossi and Nicoletta Potenza
    Citation: Journal of Biomedical Science 2024 31:59
    Content type: Review Published on:

  45. A vaccine against Trypanosoma cruzi, the agent of Chagas disease, would be an excellent additional tool for disease control. A recombinant vaccine based on Tc24 and TSA1 parasite antigens was found to be safe and...

    Authors: Eric Dumonteil, Weihong Tu, Hans Desale, Kelly Goff, Preston Marx, Jaime Ortega-Lopez and Claudia Herrera
    Citation: Journal of Biomedical Science 2024 31:58
    Content type: Research Published on:

  46. Severe infection and sepsis are medical emergencies. High morbidity and mortality are linked to CNS dysfunction, excessive inflammation, immune compromise, coagulopathy and multiple organ dysfunction. Males ap...

    Authors: Geoffrey P. Dobson, Hayley L. Letson and Jodie L. Morris
    Citation: Journal of Biomedical Science 2024 31:57
    Content type: Review Published on:

  47. Infections with Herpes simplex virus (HSV)-1 or -2 usually present as mild chronic recurrent disease, however in rare cases can result in life-threatening conditions with a large spectrum of pathology. Monoclo...

    Authors: Narges Seyfizadeh, David Kalbermatter, Thomas Imhof, Moritz Ries, Christian Müller, Leonie Jenner, Elisabeth Blumenschein, Alexandra Yendrzheyevskiy, Frank Grün, Kevin Moog, Daniel Eckert, Ronja Engel, Philipp Diebolder, Mohamed Chami, Jürgen Krauss, Torsten Schaller…
    Citation: Journal of Biomedical Science 2024 31:56
    Content type: Research Published on:

  48. Radioresistance is a key clinical constraint on the efficacy of radiotherapy in lung cancer patients. REV1 DNA directed polymerase (REV1) plays an important role in repairing DNA damage and maintaining genomic...

    Authors: Yunshang Chen, Xue Feng, Zilong Wu, Yongqiang Yang, Xinrui Rao, Rui Meng, Sheng Zhang, Xiaorong Dong, Shuangbing Xu, Gang Wu and Xiaohua Jie
    Citation: Journal of Biomedical Science 2024 31:55
    Content type: Research Published on:

  49. Alcohol-related liver disease (ALD) is a major health concern worldwide, but effective therapeutics for ALD are still lacking. Tumor necrosis factor-inducible gene 6 protein (TSG-6), a cytokine released from m...

    Authors: Jinsol Han, Chanbin Lee, Hayeong Jeong, Seunghee Jeon, Myunggyo Lee, Haeseung Lee, Yung Hyun Choi and Youngmi Jung
    Citation: Journal of Biomedical Science 2024 31:54
    Content type: Research Published on:
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Journal of Biomedical Science

ISSN: 1423-0127