Meek Peter Parker is bitten by a radioactive spider and acquires super-powers. He decides to use his new powers to get rich, but when tragedy strikes close to home, he learns a valuable lesson and vows to fight crime instead.
Dr Noah Boddy releases Electro, the Green Goblin and the Vulture to confront Spider-Man in a series of showdowns. Then, a Chameleon-like criminal eludes police and Spider-Man alike.
Trying to foil a mystery keeping the demolition of a playhouse, Spider-Man meets Blackwell the Magician who, behind his mischievous tricks, has a message to say to him...
The Scorpion, a super-human creation designed to vanquish Spider-Man, has a lethal sting in his tail and he's ready to sting J. Jonah Jameson. The Sandman heists the priceless Goliath Diamond and Spider-Man is the fall guy for the crime.
The Rhino sets a gold standard for his crime spree - by creating a statue of himself. Then, a mastermind uses a cow-boy and a thug to find blueprints to destroy New York. It's up to Spider-Man to foil and neutralize their evil plan.
In order to do a final battle with Spider-Man, the Vulture abducts J.Jonah Jameson and puts him next to a revolving pendulum. It's up to Spidey to stop the Vulture, otherwise his other nemesis Jamieson ends up in two halves.