Meek Peter Parker is bitten by a radioactive spider and acquires super-powers. He decides to use his new powers to get rich, but when tragedy strikes close to home, he learns a valuable lesson and vows to fight crime instead.
Dr Noah Boddy releases Electro, the Green Goblin and the Vulture to confront Spider-Man in a series of showdowns. Then, a Chameleon-like criminal eludes police and Spider-Man alike.
Trying to foil a mystery keeping the demolition of a playhouse, Spider-Man meets Blackwell the Magician who, behind his mischievous tricks, has a message to say to him...
The Rhino sets a gold standard for his crime spree - by creating a statue of himself. Then, a mastermind uses a cow-boy and a thug to find blueprints to destroy New York. It's up to Spider-Man to foil and neutralize their evil plan.
The Scorpion, a super-human creation designed to vanquish Spider-Man, has a lethal sting in his tail and he's ready to sting J. Jonah Jameson. The Sandman heists the priceless Goliath Diamond and Spider-Man is the fall guy for the crime.
In order to do a final battle with Spider-Man, the Vulture abducts J.Jonah Jameson and puts him next to a revolving pendulum. It's up to Spidey to stop the Vulture, otherwise his other nemesis Jamieson ends up in two halves.
The Flys, a.k.a. the Patterson Twins, are paroled and freed. However, Spider-Man does not believe this and for a reason: they are framing him for all the heists they've done. It's up to Spidey to catch them in their act.
