Kevin learns what it's like to be a dog when aliens adopt him as their pet. When dogs all over the city start acting like other animals, Krypto investigates and discovers that Mechanikat is the cause.
When Krypto loses his powers because of red kryptonite, Bathound tries to equip him with bat gear. Krypto is stalked by a companion robot dog from Krypton who is programmed to be his best friend.
Snooky attacks Krypto with an aging machine and inadvertently ages Kevin into an adult. Bat Hound finds his life turned upside down when Thunder Mutt follows him around as research for his next role a dog detective.
When Krypto is captured by Mechanikat, the Dog Stars send in a reluctant Streaky to sneak aboard Mechanikat's ship. Krypto and Kevin are reduced in size by aliens who are collecting specimens from other worlds.
Kevin and Andrea team up when they become super-powered like Krypto.Krypto and Kevin are transferred into a videogame that tests their game-playing skills and superpowers.
Streaky tries to be a big-time superhero to impress his nephew, Squeaky. A movie star dog makes a pact with Snooky so that the actor can wear a super suit that gives him powers.
Bathound has a crisis in confidence when he pursues Catwoman's cat, Isis, who is able to use a bad luck charm against him. Krypto must come to the rescue of the Dog Stars when they are forced to perform in a space circus.
When Andrea learns that Krypto and Streaky are really Superdog and Supercat, she joins them and Kevin in a battle against Mechanikat. Bat Hound has to team up with Stretch-O-Mutt when Merton the Magic Rabbit captures Krypto.
Streaky and Stretch-O-Mutt team up on the docks to battle a sinister parrot captain and his crew of rats. Robbie the Bird Wonder teams with Streaky to save Bat Hound and Krypto.
In order to control the Dog Stars, Mechanikat turns them into puppies. Krypto is forced to partner with Ignatius while investigating thefts within Lexcorp.
