Ronan the Accuser of the Kree Empire arrives at Earth with Captain Mar-Vel in tow to pass judgment on whether the planet should be annexed or destroyed.
With Captain America's reputation now in tatters, the superhero and the similarly maligned Spider-Man find themselves trying to thwart a prisoner-transport interception.
When The Enchantress magically weakens Thor, Iron Man and Captain America, only Hawkeye is unaffected as the Wrecking Crew and Loki in the Destroyer body pursue them.
When there is a sudden exposure of a toxin around the Avengers Mansion, the Secretary of Defense blames the Avengers and lays siege to the headquarters.
While dealing with the Red Skull's escape with his Sleeper robots, Captain America also investigates the villain's former henchman who seems disturbingly familiar.