Angelica takes advantage of a family problem to make Tommy and Chuckie play a game of house. Tommy and the babies help Chuckie take care of what he thinks is the last balloon in the whole wide world.
When Grandpa's hurt back keeps him from his favorite event,Tommy enlists his friends to create the event at home. Angelica's new talking doll is a shock to her and a surprise to the babies.
Tommy's dad invents a robot dog that's allergy-free for Chuckie and Chas, but not necessarily problem-free. Angelica uses an argument between the twins to trick Phil into becoming her personal assistant.
Tommy needs his friends' help to save Angelica after she turns into a werewolf at a scary Halloween party where their parents seem to be disappearing one by one.
To bring Chuckie home, the gang embark on an adventure that takes them to an animal-filled jungle, through a dark cave, and even into the mouth of an active volcano.
When a "professional organizer" comes over, it's up to Tommy and his friends to stop her from taking all the toys. When Tommy's parents bring home a foster puppy, Tommy must find a way to keep Spike from being replaced.
When the babies' favorite song gets 'stuck' in Chas's head, Tommy and the babies go on a quest to get it unstuck. Tommy and Chuckie discover that playing music might threaten their friendship.
Tommy and Chuckie fear their friendship is over when Angelica says they're too different to be best friends. Susie, Tommy, and Chuckie must defeat an "outer space villain" while at a sci-fi movie convention with their dads.
Angelica uses the face filters on her phone to trick Susie into thinking she's going to turn into a taco. Tommy takes charge to help Chuckie send a message to his Reptar doll who they think traveled back to outer space.