PE20090329A1 - HUMANIZED ANTIBODIES AGAINST GLOBULOMER AB (20-42) AND ITS USES - Google Patents

HUMANIZED ANTIBODIES AGAINST GLOBULOMER AB (20-42) AND ITS USES

Info

Publication number
PE20090329A1
PE20090329A1 PE2008000921A PE2008000921A PE20090329A1 PE 20090329 A1 PE20090329 A1 PE 20090329A1 PE 2008000921 A PE2008000921 A PE 2008000921A PE 2008000921 A PE2008000921 A PE 2008000921A PE 20090329 A1 PE20090329 A1 PE 20090329A1
Authority
PE
Peru
Prior art keywords
cdr
containing seq
globulomer
antibodies against
humanized antibodies
Prior art date
Application number
PE2008000921A
Other languages
Spanish (es)
Inventor
Stefan Barghorn
Heinz Hillen
Patrick Keller
Andreas R Striebinger
Boris Labkovsky
Paul R Hinton
Veronica M Juan
Original Assignee
Abbott Lab
Abbott Gmbh & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39791050&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20090329(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbott Lab, Abbott Gmbh & Co Kg filed Critical Abbott Lab
Publication of PE20090329A1 publication Critical patent/PE20090329A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plant Pathology (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE REFIERE A UNA PROTEINA DE UNION TAL COMO UNA MOLECULA DE INMUNOGLOBULINA, UN ANTICUERPO MONOCLONAL, UN ANTICUERPO HUMANIZADO, UN Fab, ENTRE OTROS, QUE COMPRENDE UN DOMINIO DE UNION A ANTIGENO QUE SE UNE AL GLOBULOMERO BETA AMILOIDE(20-42) QUE COMPRENDE UNA CDR CUYA SECUENCIA DE AMINOACIDOS CONSISTE EN: A) CDR-VH1 QUE CONTIENE LA SEC ID Nº 5; B) CDR-VH2 QUE CONTIENE LA SEC ID Nº 6; C) CDR-VH3 QUE CONTIENE LA SEC ID Nº 7; D) CDR-VL1 QUE CONTIENE LA SEC ID Nº 8; E) CDR-VL2 QUE CONTIENE LA SEC ID Nº 9; CDR-VL3 QUE CONTIENE LA SEC ID Nº 10. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA QUE CONTIENE DICHA PROTEINA DE UNION O UN ANTICUERPO CONJUGADO EN FORMA DE CRISTAL, SIENDO UTIL EN EL TRATAMIENTO Y DIAGNOSTICO DE LA ENFERMEDAD DE ALZHEIMERREFERS TO A BINDING PROTEIN SUCH AS AN IMMUNOGLOBULIN MOLECULE, A MONOCLONAL ANTIBODY, A HUMANIZED ANTIBODY, A Fab, AMONG OTHERS, WHICH INCLUDES AN ANTIGENOUS BINDING DOMAIN THAT JOINS THE GLOBULOMER 20-42 AMYLUMER BENDETA A CDR WHOSE SEQUENCE OF AMINO ACIDS CONSISTS OF: A) CDR-VH1 CONTAINING SEQ ID NO: 5; B) CDR-VH2 CONTAINING SEQ ID NO: 6; C) CDR-VH3 CONTAINING SEQ ID NO: 7; D) CDR-VL1 CONTAINING SEQ ID NO: 8; E) CDR-VL2 CONTAINING SEQ ID NO: 9; CDR-VL3 CONTAINING SEQ ID NO 10. ALSO REFERS TO A PHARMACEUTICAL COMPOSITION CONTAINING SAID BINDING PROTEIN OR A CONJUGATED ANTIBODY IN THE FORM OF A CRYSTAL, BEING USEFUL IN THE TREATMENT AND DIAGNOSIS OF ALZHEIMER DISEASE

PE2008000921A 2007-05-30 2008-05-29 HUMANIZED ANTIBODIES AGAINST GLOBULOMER AB (20-42) AND ITS USES PE20090329A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94093207P 2007-05-30 2007-05-30
US99035907P 2007-11-27 2007-11-27

Publications (1)

Publication Number Publication Date
PE20090329A1 true PE20090329A1 (en) 2009-03-27

Family

ID=39791050

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008000921A PE20090329A1 (en) 2007-05-30 2008-05-29 HUMANIZED ANTIBODIES AGAINST GLOBULOMER AB (20-42) AND ITS USES

Country Status (22)

Country Link
US (1) US20090175847A1 (en)
EP (1) EP2150563A1 (en)
JP (1) JP2010530740A (en)
KR (1) KR20100032398A (en)
CN (1) CN101827862A (en)
AR (1) AR066794A1 (en)
AU (1) AU2008260062A1 (en)
BR (1) BRPI0812005A2 (en)
CA (1) CA2687414A1 (en)
CL (1) CL2008001580A1 (en)
CO (1) CO6251291A2 (en)
CR (1) CR11179A (en)
DO (1) DOP2009000269A (en)
EC (1) ECSP099833A (en)
IL (1) IL202243A0 (en)
MX (1) MX2009012950A (en)
PA (1) PA8782201A1 (en)
PE (1) PE20090329A1 (en)
RU (1) RU2009149370A (en)
TW (1) TW200914465A (en)
UY (1) UY31114A1 (en)
WO (1) WO2008150949A1 (en)

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Also Published As

Publication number Publication date
IL202243A0 (en) 2010-06-16
CO6251291A2 (en) 2011-02-21
JP2010530740A (en) 2010-09-16
WO2008150949A1 (en) 2008-12-11
KR20100032398A (en) 2010-03-25
ECSP099833A (en) 2010-01-29
US20090175847A1 (en) 2009-07-09
CA2687414A1 (en) 2008-12-11
TW200914465A (en) 2009-04-01
BRPI0812005A2 (en) 2019-09-24
UY31114A1 (en) 2009-01-05
DOP2009000269A (en) 2009-12-15
AU2008260062A1 (en) 2008-12-11
MX2009012950A (en) 2010-03-26
PA8782201A1 (en) 2009-02-09
AR066794A1 (en) 2009-09-09
CL2008001580A1 (en) 2008-12-05
EP2150563A1 (en) 2010-02-10
CR11179A (en) 2010-05-27
RU2009149370A (en) 2011-07-10
CN101827862A (en) 2010-09-08

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