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Rfam 15.1 (January 2026, 4227 families)

The Rfam database is a collection of RNA families, each represented by multiple sequence alignments, consensus secondary structures and covariance models

Try: SAM riboswitch Homo sapiens snoRNA author:"Weinberg"
Browse: Families Clans Motifs Genomes Sequences Families with 3D structures

Browse Rfam

Families

RNA families by type, name, or accession

Clans

Related families sharing a common ancestor

Motifs

Recurrent 3D structural motifs

Genomes

Annotated ncRNA across genomes

Sequences

Genomic and metagenomic sequences with Rfam hits

Getting Started

Sequence Search

Search for RNA families by nucleotide sequence. FASTA format is supported.

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Can't find what you're looking for? Use the AI assistant to ask questions about Rfam data, families, alignments, and more. Click the chat button in the bottom-right corner of the page to open the assistant. The assistant is powered by DocBot, an EMBL-EBI AI service that answers questions from user documentation across EBI resources. For more information on the underlying service, see the DocBot project page.

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Featured Families

Database Statistics

Rfam families over time

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