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Matthew SimsUC Berkeley Подтвержден адрес электронной почты в домене berkeley.edu Цитируется: 160 |
Common variants near MC4R are associated with fat mass, weight and risk of obesity
…, SM Ring, MS Sandhu, A Scherag, MA Sims… - Nature …, 2008 - nature.com
To identify common variants influencing body mass index (BMI), we analyzed genome-wide
association data from 16,876 individuals of European descent. After previously reported …
association data from 16,876 individuals of European descent. After previously reported …
SER-109, an Oral Microbiome Therapy for Recurrent Clostridioides difficile Infection
…, EEL Wang, L Diao, JA Bryant, M Sims… - … England Journal of …, 2022 - Mass Medical Soc
Background Current therapies for recurrent Clostridioides difficile infection do not address
the disrupted microbiome, which supports C. difficile spore germination into toxin-producing …
the disrupted microbiome, which supports C. difficile spore germination into toxin-producing …
Bile salt hydrolase acyltransferase activity expands bile acid diversity
…, AL Schilmiller, WM Miller, KM Ziegler, MD Sims… - Nature, 2024 - nature.com
Bile acids (BAs) are steroid detergents in bile that contribute to the absorption of fats and fat-soluble
vitamins while shaping the gut microbiome because of their antimicrobial properties …
vitamins while shaping the gut microbiome because of their antimicrobial properties …
Genetic variation in LIN28B is associated with the timing of puberty
…, AR Ness, K Northstone, SM Ring, C Rubin, MA Sims… - Nature …, 2009 - nature.com
The timing of puberty is highly variable 1 . We carried out a genome-wide association study
for age at menarche in 4,714 women and report an association in LIN28B on chromosome 6 (…
for age at menarche in 4,714 women and report an association in LIN28B on chromosome 6 (…
LDL-cholesterol concentrations: a genome-wide association study
Background LDL cholesterol has a causal role in the development of cardiovascular disease.
Improved understanding of the biological mechanisms that underlie the metabolism and …
Improved understanding of the biological mechanisms that underlie the metabolism and …
A POMC variant implicates β-melanocyte-stimulating hormone in the control of human energy balance
…, JM Keogh, ME Madonna, V Wraight, M Sims… - Cell metabolism, 2006 - cell.com
The melanocortin-4 receptor (MC4R) plays a critical role in the control of energy balance. Of
its two pro-opiomelanocortin (POMC)-derived ligands, α- and β-MSH, the majority of …
its two pro-opiomelanocortin (POMC)-derived ligands, α- and β-MSH, the majority of …
The emperor's new clothes: prospective observational evaluation of the association between initial vancomycin exposure and failure rates among adult hospitalized …
…, M Finnemeyer, S Evans, M Sims… - Clinical infectious …, 2020 - academic.oup.com
Background Vancomycin is the most commonly administered antibiotic in hospitalized
patients, but optimal exposure targets remain controversial. To clarify the therapeutic exposure …
patients, but optimal exposure targets remain controversial. To clarify the therapeutic exposure …
Colistin monotherapy versus combination therapy for carbapenem-resistant organisms
…, E Roilides, M Rybak, M Samarkos, M Sims… - NEJM …, 2022 - evidence.nejm.org
Background Pneumonia and bloodstream infections (BSI) due to extensively drug-resistant (XDR)
Acinetobacter baumannii, XDR Pseudomonas aeruginosa, and carbapenem-resistant …
Acinetobacter baumannii, XDR Pseudomonas aeruginosa, and carbapenem-resistant …
Safety and tolerability of SER-109 as an investigational microbiome therapeutic in adults with recurrent Clostridioides difficile infection: a phase 3, open-label, single …
Importance A safe and effective treatment for recurrentClostridioides difficileinfection (CDI)
is urgently needed. Antibiotics kill toxin-producing bacteria but do not repair the disrupted …
is urgently needed. Antibiotics kill toxin-producing bacteria but do not repair the disrupted …
Prospective, randomized, double-blind, phase 2 dose-ranging study comparing efficacy and safety of imipenem/cilastatin plus relebactam with imipenem/cilastatin …
M Sims, V Mariyanovski, P McLeroth… - Journal of …, 2017 - academic.oup.com
… Matthew Sims has received research funding and travel grants from Merck & Co., Inc. Valeri
Mariyanovski has received research funding from Merck & Co., Inc. Patrick McLeroth, Wayne …
Mariyanovski has received research funding from Merck & Co., Inc. Patrick McLeroth, Wayne …