Binospiron

Binospiron
(IUPAC) ime
	8-[2-(2,3-dihidro-1,4-benzodioksin-2-ilmetilamino)etil]-8-azaspiro[4.5]dekan-7,9-dion
Klinički podaci
Identifikatori
CAS broj	124756-23-6
ATC kod	nije dodeljen
PubChem	60769
ChemSpider	54766
UNII	T3M5D109V5
Hemijski podaci
Formula	C20H26N2O4
Mol. masa	358,431 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C20H26N2O4/c23-18-11-20(7-3-4-8-20)12-19(24)22(18)10-9-21-13-15-14-25-16-5-1-2-6-17(16)26-15/h1-2,5-6,15,21H,3-4,7-14H2 ; Key: BVMYCHKQPGEOSI-UHFFFAOYSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

Binospiron (MDL-73,005-EF) je lek koji deluje kao parcijalni agonist na 5-HT_1A somatodendritiskim autoreceptorima, i kao antagonist na postsinaptičkim 5-HT_1A receptorima.^[4] On ima anksiolitsko dejstvo.^[5]

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Bertrand, F; Lehmann, O; Galani, R; Lazarus, C; Jeltsch, H; Cassel, JC (2001). „Effects of MDL 73005 on water-maze performances and locomotor activity in scopolamine-treated rats”. Pharmacology, Biochemistry, and Behavior 68 (4): 647–60. DOI:10.1016/S0091-3057(01)00448-8. PMID 11526961.
↑ Moser, PC; Tricklebank, MD; Middlemiss, DN; Mir, AK; Hibert, MF; Fozard, JR (1990). „Characterization of MDL 73005EF as a 5-HT1A selective ligand and its effects in animal models of anxiety: comparison with buspirone, 8-OH-DPAT and diazepam”. British Journal of Pharmacology 99 (2): 343–9. PMC 1917389. PMID 1970269.

Povezano

Azapiron

Spoljašnje veze

	Portal Medicina
	Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Bertrand, F; Lehmann, O; Galani, R; Lazarus, C; Jeltsch, H; Cassel, JC (2001). „Effects of MDL 73005 on water-maze performances and locomotor activity in scopolamine-treated rats”. Pharmacology, Biochemistry, and Behavior 68 (4): 647–60. DOI:10.1016/S0091-3057(01)00448-8. PMID 11526961.

[5] Moser, PC; Tricklebank, MD; Middlemiss, DN; Mir, AK; Hibert, MF; Fozard, JR (1990). „Characterization of MDL 73005EF as a 5-HT1A selective ligand and its effects in animal models of anxiety: comparison with buspirone, 8-OH-DPAT and diazepam”. British Journal of Pharmacology 99 (2): 343–9. PMC 1917389. PMID 1970269.

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