EPH receptor B2

EPH receptor B2
	; PDB prikaz baziran na 1b4f.
Dostupne strukture
	1B4F, 1F0M, 2QBX, 3ZFM
Identifikatori
Simboli	EPHB2; CAPB; DRT; EK5; EPHT3; ERK; Hek5; PCBC; Tyro5
Vanjski ID	OMIM: 600997 MGI: 99611 HomoloGene: 37925 GeneCards: EPHB2 Gene
EC broj	2.7.10.1
Ontologija gena
Molekulska funkcija	• aktivnost proteinske tirozinske kinaze; • aktivnost transmembranskog efrinskog receptora; • receptorsko vezivanje;
Ćelijska komponenta	• integralna komponenta ćelijske membrane; • akson; • dendrit;
Biološki proces	• angiogeneza; • razviće urogenitalnog sistema; • razviće nervnog sistema;
Pregled RNK izražavanja
	podaci
Ortolozi

edit

Receptor 2 efrinskog tipa B je protein koji je kod ljudi kodiran EPHB2 genom.^[1]

Funkcija

Ephrinski receptori i njihovi ligandi, efrini, posreduju brojne procese razvića, posebno u nervnom sistemu. Na bazi njihovih struktura i sekvenci, efrini se dele u efrinsku klasu A (EFNA), koja se fiksira na membrani putem glikozilfosfatidilinozitolne veze, i efrinsku klasu B (EFNB), koji su transmembranski proteini. Eph familija receptora se deli u dve groupe na osnovu sličnosti njihovih sekvenci ekstracelularnog domena i njihovog afiniteta vezivanja liganda efrina A i efrina B. Efrinski receptori su najveća podgrupa receptora tirozinske kinazne (RTK) familije. Protein kodiran ovim genom je receptor za efrinske-B članove familije.^[2]

Interakcije

EPH receptor B2 formira interakcije sa Src,^[3]^[4] RAS p21 proteinskim aktivatorom 1^[5] i Abl genom.^[6]

Reference

↑ Chan J, Watt VM (August 1991). „eek and erk, new members of the eph subclass of receptor protein-tyrosine kinases”. Oncogene 6 (6): 1057–61. PMID 1648701.
↑ „Entrez Gene: EPHB2 EPH receptor B2”.
↑ Zisch AH, Kalo MS, Chong LD, Pasquale EB (May 1998). „Complex formation between EphB2 and Src requires phosphorylation of tyrosine 611 in the EphB2 juxtamembrane region”. Oncogene 16 (20): 2657–70. DOI:10.1038/sj.onc.1201823. PMID 9632142.
↑ Zisch AH, Pazzagli C, Freeman AL, Schneller M, Hadman M, Smith JW, Ruoslahti E, Pasquale EB (January 2000). „Replacing two conserved tyrosines of the EphB2 receptor with glutamic acid prevents binding of SH2 domains without abrogating kinase activity and biological responses”. Oncogene 19 (2): 177–87. DOI:10.1038/sj.onc.1203304. PMID 10644995.
↑ Holland SJ, Gale NW, Gish GD, Roth RA, Songyang Z, Cantley LC, Henkemeyer M, Yancopoulos GD, Pawson T (July 1997). „Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells”. EMBO J. 16 (13): 3877–88. DOI:10.1093/emboj/16.13.3877. PMC 1170012. PMID 9233798.
↑ Yu HH, Zisch AH, Dodelet VC, Pasquale EB (July 2001). „Multiple signaling interactions of Abl and Arg kinases with the EphB2 receptor”. Oncogene 20 (30): 3995–4006. DOI:10.1038/sj.onc.1204524. PMID 11494128.

[pmid1648701-1] Chan J, Watt VM (August 1991). „eek and erk, new members of the eph subclass of receptor protein-tyrosine kinases”. Oncogene 6 (6): 1057–61. PMID 1648701.

[2] „Entrez Gene: EPHB2 EPH receptor B2”.

[pmid9632142-3] Zisch AH, Kalo MS, Chong LD, Pasquale EB (May 1998). „Complex formation between EphB2 and Src requires phosphorylation of tyrosine 611 in the EphB2 juxtamembrane region”. Oncogene 16 (20): 2657–70. DOI:10.1038/sj.onc.1201823. PMID 9632142.

[pmid10644995-4] Zisch AH, Pazzagli C, Freeman AL, Schneller M, Hadman M, Smith JW, Ruoslahti E, Pasquale EB (January 2000). „Replacing two conserved tyrosines of the EphB2 receptor with glutamic acid prevents binding of SH2 domains without abrogating kinase activity and biological responses”. Oncogene 19 (2): 177–87. DOI:10.1038/sj.onc.1203304. PMID 10644995.

[pmid9233798-5] Holland SJ, Gale NW, Gish GD, Roth RA, Songyang Z, Cantley LC, Henkemeyer M, Yancopoulos GD, Pawson T (July 1997). „Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells”. EMBO J. 16 (13): 3877–88. DOI:10.1093/emboj/16.13.3877. PMC 1170012. PMID 9233798.

[pmid11494128-6] Yu HH, Zisch AH, Dodelet VC, Pasquale EB (July 2001). „Multiple signaling interactions of Abl and Arg kinases with the EphB2 receptor”. Oncogene 20 (30): 3995–4006. DOI:10.1038/sj.onc.1204524. PMID 11494128.

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