Fosfatidinska kiselina

Fosfatidinske kiseline (PA) su kiselinske forme fosfatidata, dela običnih fosfolipida, glavnih konstituenata ćelijskih membrana. Fosfatidinske kiseline su najjednostavniji diacil-glicerofosfolipidi.^[1]

Struktura

Fosfatidinska kiselina se sastoji od glicerolne osnove, sa u opštem slučaju zasićenom masnom kiselinom vezanom za ugljenik-1, nezasićenom masnom kiselinom na ugljeniku-2, i fosfatnom grupom na ugljeniku-3.^[1]^[2]

Formiranje i degradacija

Pored de novo sinteze, fosfatidinska kiselina se može formirati na tri načina:

Fosfolipazom D (PLD), putem hidrolize P-O veze fosfatidilholina, čime se formira PA holin.^[3]
Fosforilacijom diacilglicerola (DAG) posredstvom DAG kinaze (DAGK)
Acilacijom lizofosfatidne kiseline pomoću lizoPA-aciltransferaze (LPAAT); to je najčešći metabolički put.^[4]

Fosfatidinska kiselina se razgrađuje konverzijom u DAG dejstvom lipidnih fosfatnih fosfohidrolaza^[5]^[6] ili u lizo-PA pomoću fosfolipaze A (PLA).

Reference

↑ ^1,0 ^1,1 William W. Christie (4/10/2009). „Phosphatidic Acid, Lysophosphatidic Acid and Related Lipids”. Pristupljeno 5 November 2009.
↑ Schroeder, R.; London, E.; Brown, D. (December 1994). „Interactions between saturated acyl chains confer detergent resistance on lipids and glycosylphosphatidylinositol (GPI)-anchored proteins: GPI-anchored proteins in liposomes and cells show similar behavior”. Proceedings of the National Academy of Sciences of the United States of America 91 (25): 12130–12134. Bibcode 1994PNAS...9112130S. DOI:10.1073/pnas.91.25.12130. PMC 45390. PMID 7991596. Arhivirano iz originala na datum 2015-09-24. Pristupljeno 2014-04-15.
↑ Liscovitch M, Czarny M, Fiucci G, Tang X (February 2000). „Phospholipase D: molecular and cell biology of a novel gene family”. Biochem. J. 345 Pt 3 (3): 401–15. DOI:10.1042/0264-6021:3450401. PMC 1220771. PMID 10642495.
↑ Devlin, T. M. 2004. Bioquímica, 4ª edición. Reverté, Barcelona. ISBN 84-291-7208-4
↑ Brindley DN, Waggoner DW (May 1996). „Phosphatidate phosphohydrolase and signal transduction”. Chem. Phys. Lipids 80 (1–2): 45–57. DOI:10.1016/0009-3084(96)02545-5. PMID 8681429.
↑ Brindley DN, Waggoner DW (September 1998). „Mammalian lipid phosphate phosphohydrolases”. J. Biol. Chem. 273 (38): 24281–4. DOI:10.1074/jbc.273.38.24281. PMID 9733709.

Spoljašnje veze

Phosphatidic Acid: From Biophysics to Physiology Arhivirano 2014-07-15 na Wayback Machine-u

[William_W_Christie-1] 1,0 ^1,1 William W. Christie (4/10/2009). „Phosphatidic Acid, Lysophosphatidic Acid and Related Lipids”. Pristupljeno 5 November 2009.

[2] Schroeder, R.; London, E.; Brown, D. (December 1994). „Interactions between saturated acyl chains confer detergent resistance on lipids and glycosylphosphatidylinositol (GPI)-anchored proteins: GPI-anchored proteins in liposomes and cells show similar behavior”. Proceedings of the National Academy of Sciences of the United States of America 91 (25): 12130–12134. Bibcode 1994PNAS...9112130S. DOI:10.1073/pnas.91.25.12130. PMC 45390. PMID 7991596. Arhivirano iz originala na datum 2015-09-24. Pristupljeno 2014-04-15.

[pmid10642495-3] Liscovitch M, Czarny M, Fiucci G, Tang X (February 2000). „Phospholipase D: molecular and cell biology of a novel gene family”. Biochem. J. 345 Pt 3 (3): 401–15. DOI:10.1042/0264-6021:3450401. PMC 1220771. PMID 10642495.

[Dev-4] Devlin, T. M. 2004. Bioquímica, 4ª edición. Reverté, Barcelona. ISBN 84-291-7208-4

[pmid8681429-5] Brindley DN, Waggoner DW (May 1996). „Phosphatidate phosphohydrolase and signal transduction”. Chem. Phys. Lipids 80 (1–2): 45–57. DOI:10.1016/0009-3084(96)02545-5. PMID 8681429.

[pmid9733709-6] Brindley DN, Waggoner DW (September 1998). „Mammalian lipid phosphate phosphohydrolases”. J. Biol. Chem. 273 (38): 24281–4. DOI:10.1074/jbc.273.38.24281. PMID 9733709.

[1]

[2]

[3]

[4]

[5]

[6]