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Farmakokinetika

Izvor: Wikipedija

Farmakokinetika, skraćeno PK, (od starogrčkog pharmakon "lek" i kinetikos "vezano za kretanje") je grana farmakologije koja se bavi izučavanjem promena supstanci doziranih u žive organizme. Supstance od interesa su farmaceutski agensi, hormoni, nutrijenti, i toksini. Ona pokužava da otkrije sudbinu leka od momenta njegovog unosa do tačke u kojoj je kompletno eliminisan iz tela.

Farmakokinetika se može jednostavno definisati kao to što telo radi leku, dok je farmakodinamika usredsređena na to što lek radi telu.[1]

Grafikon koji demonstrira Mihaelis-Menteninov kinetčki model odnosa između enzima i supstrata

Farmakokinetika opisuje kako telo deluje na specifični lek nakon doziranja putem mehanizama apsorpcije i distribucije, kao i hemijske promene supstane u telu (e.g. posredstvom metaboličkih enzima kao što su enzimi citohrom P450 ili glukuronoziltransferaza), i efekte i puteve izlučivanja metabolita leka.[2] Farmakokinetička svojstva leka mogu da budu uslovljena faktorima poput mesta administriranja i doze leka. Ti faktori mogu da utiču na brzinu apsorpcije.[3] Farmakokinetika se često studira zajedno sa farmakodinamikom.

Reference

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  1. ↑ Benet LZ (1984). „Pharmacokinetics: Basic Principles and Its Use as a Tool in Drug Metabolism”. u: Horning MG, Mitchell J. Drug metabolism and drug toxicity. New York: Raven Press. ISBN 0-89004-997-1. Arhivirano iz originala na datum 2013-10-20. Pristupljeno 2014-03-11. 
  2. ↑ Pharmacokinetics. (2006). In Mosby's Dictionary of Medicine, Nursing, & Health Professions. Philadelphia, PA: Elsevier Health Sciences. Retrieved December 11, 2008, from http://www.credoreference.com/entry/6686418
  3. ↑ Kathleen Knights; Bronwen Bryant (2002). Pharmacology for Health Professionals. Amsterdam: Elsevier. ISBN 0-7295-3664-5. 

Literatura

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  • Kathleen Knights; Bronwen Bryant (2002). Pharmacology for Health Professionals. Amsterdam: Elsevier. ISBN 0-7295-3664-5. 
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  • Kathleen Knights; Bronwen Bryant (2002). Pharmacology for Health Professionals. Amsterdam: Elsevier. ISBN 0-7295-3664-5.
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Izvor: https://sh.wikipedia.org/w/index.php?title=Farmakokinetika&oldid=42170488