KF-26777

KF-26777
(IUPAC) ime
	(2-(4-bromofenil)-7,8-dihidro-4-propil-1H-imidazo[2,1-i]purin-5(4H)-on
Klinički podaci
Identifikatori
ATC kod	nije dodeljen
Hemijski podaci
Formula	C16H18BrN5O
Mol. masa	376,250 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C16H18BrN5O/c1-2-8-21-15-12(14-18-7-9-22(14)16(21)23)19-13(20-15)10-3-5-11(17)6-4-10/h3-6,12,15H,2,7-9H2,1H3,(H,19,20) ; Key: OLRSEPJSXUABDN-UHFFFAOYSA-N
Sinonimi	KF-26777
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

KF-26777 je lek koji deluje kao potentan i selektivan antagonist adenozinskog A₃ receptora, nanomolarnim afinitetom (A₃ Ki=0.2nM) i visokom selektivnošću u odnosu na druge adenozinske receptore.^[1] Jednostavni ksantinski derivati kao što je kofein i DPCPX generalno imaju nizak afinitet za A₃ receptor, te moraju da budu prošireni dodatkom aromatične grupe.^[2]

Reference

↑ Saki M, Tsumuki H, Nonaka H, Shimada J, Ichimura M (May 2002). „KF26777 (2-(4-bromophenyl)-7,8-dihydro-4-propyl-1H-imidazo[2,1-ipurin-5(4H)-one dihydrochloride), a new potent and selective adenosine A3 receptor antagonist”]. European Journal of Pharmacology 444 (3): 133–41. DOI:10.1016/S0014-2999(02)01662-X. PMID 12063073.
↑ Baraldi PG, Tabrizi MA, Gessi S, Borea PA (January 2008). „Adenosine receptor antagonists: translating medicinal chemistry and pharmacology into clinical utility”. Chemical Reviews 108 (1): 238–63. DOI:10.1021/cr0682195. PMID 18181659.

Spoljašnje veze

	Portal Medicina
	Portal Hemija

[pmid12063073-1] Saki M, Tsumuki H, Nonaka H, Shimada J, Ichimura M (May 2002). „KF26777 (2-(4-bromophenyl)-7,8-dihydro-4-propyl-1H-imidazo[2,1-ipurin-5(4H)-one dihydrochloride), a new potent and selective adenosine A3 receptor antagonist”]. European Journal of Pharmacology 444 (3): 133–41. DOI:10.1016/S0014-2999(02)01662-X. PMID 12063073.

[pmid18181659-2] Baraldi PG, Tabrizi MA, Gessi S, Borea PA (January 2008). „Adenosine receptor antagonists: translating medicinal chemistry and pharmacology into clinical utility”. Chemical Reviews 108 (1): 238–63. DOI:10.1021/cr0682195. PMID 18181659.

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