Naringenin
| (IUPAC) ime | |||
|---|---|---|---|
| 5,7-dihidroksi-2-(4-hidroksifenil)hroman-4-on | |||
| Klinički podaci | |||
| Identifikatori | |||
| CAS broj | 480-41-1 | ||
| ATC kod | nije dodeljen | ||
| PubChem[1][2] | 439246 | ||
| DrugBank | DB03467 | ||
| ChemSpider[3] | 388383 | ||
| UNII | HN5425SBF2 | ||
| ChEMBL[4] | CHEMBL9352 | ||
| Hemijski podaci | |||
| Formula | C15H12O5 | ||
| Mol. masa | 272,257 g/mol | ||
| |||
| Sinonimi | 4',5,7-trihidroksiflavanon | ||
| Farmakoinformacioni podaci | |||
| Trudnoća | ? | ||
| Pravni status | |||
Naringenin je flavanon, tip flavonoida. Smatra se da ima bioaktivno dejstvo na ljudsko zdravlje kao antioksidans, sakupljač slobodnih radicala , antiinflamatorno sredstvo, promoter ugljeno hidratnog metabolizma, i mogulator imunskog sistema. On je predominantni flavanon u grejpfrutu.[5]
Cunninghamella elegans, gljivični model organizam sisarskog metabolizma, se može koristiti za studiranje naringenin sulfacije.[6]
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.
- ↑ "Bioavailability of the flavanone naringenin and its glycosides in rats"
- ↑ Sulfation of naringenin by Cunninghamella elegans. Abdel-Rahim S. Ibrahim, Phytochemistry, Volume 53, Issue 2, January 2000, pages 209-212, DOI:10.1016/S0031-9422(99)00487-2