Neuromedinski U receptor

Neuromedinski U receptor 2
Identifikatori
Simbol	NMUR2
Alt. simboli	NMU2R
Entrez	56923
HUGO	16454
OMIM	605108
RefSeq	NM_020167
UniProt	Q9GZQ4
Drugi podaci
Lokus	Hromozom 5 q33.1

Neuromedinski U receptor 1
Identifikatori
Simbol	NMUR1
Alt. simboli	GPR66
Entrez	10316
HUGO	4518
OMIM	604153
RefSeq	NM_006056
UniProt	Q9HB89
Drugi podaci
Lokus	Hromozom 2 q37.1

Neuromedinski U receptori su G protein spregnuti receptori koji vezuju neuropeptidne hormone neuromedin U i neuromedin S.^[1] Postoje dva tipa neuromedin U receptora, koji su kodirani zasebnim genima (NMUR1, NMUR2).

Selektivni ligandi

Neuromedin U je agonist NMU₁ i NMU₂ tipa, dok je neuromedin S selektivan za NMU₂, i on je potentniji agonist od neuromedina U.^[2]^[3] Nekoliko drugih peptidnih i ne-peptidnih liganda NMU receptora je takođe poznato.

Agonisti

Neselektivni

Neuromedin U
ne-peptidni NMU modulatori^[4]^[5]

NMU₂ selektivni

Neuromedin S

Antagonisti

NMU₂ selectivni

R-PSOP^[6]

Literatura

↑ Brighton PJ, Szekeres PG, Willars GB (June 2004). „Neuromedin U and its receptors: structure, function, and physiological roles”. Pharmacological Reviews 56 (2): 231–48. DOI:10.1124/pr.56.2.3. PMID 15169928.
↑ Mitchell J, Maguire J, Davenport A (June 2009). „Emerging pharmacology and physiology of neuromedin U and the structurally related peptide neuromedin S”. British Journal of Pharmacology 158 (1): 87–103. DOI:10.1111/j.1476-5381.2009.00252.x. PMC 2795236. PMID 19519756.
↑ Peier A, Kosinski J, Cox-York K, Qian Y, Desai K, Feng Y, Trivedi P, Hastings N, Marsh DJ (July 2009). „The antiobesity effects of centrally administered neuromedin U and neuromedin S are mediated predominantly by the neuromedin U receptor 2 (NMUR2)”. Endocrinology 150 (7): 3101–9. DOI:10.1210/en.2008-1772. PMC 2703546. PMID 19324999.
↑ Meng T, Su HR, Binkert C, Fischli W, Zhou L, Shen JK, Wang MW (April 2008). „Identification of non-peptidic neuromedin U receptor modulators by a robust homogeneous screening assay”. Acta Pharmacologica Sinica 29 (4): 517–27. DOI:10.1111/j.1745-7254.2008.00769.x. PMID 18358099.
↑ Kajino M, Hinuma S, Tarui N, Yamashita T, Nakayama Y. Receptor regulators. European Patent EP 1559428 A1. Published 03.08.2005
↑ Liu JJ, Payza K, Huang J, Liu R, Chen T, Coupal M, Laird JM, Cao CQ, Butterworth J, Lapointe S, Bayrakdarian M, Trivedi S, Bostwick JR (July 2009). „Discovery and pharmacological characterization of a small-molecule antagonist at neuromedin U receptor NMUR2”. The Journal of Pharmacology and Experimental Therapeutics 330 (1): 268–75. DOI:10.1124/jpet.109.152967. PMID 19369576.

Spoljašnje veze

„Neuromedin U Receptors”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03.
MeSH Neuromedin+U+Receptor

[pmid15169928-1] Brighton PJ, Szekeres PG, Willars GB (June 2004). „Neuromedin U and its receptors: structure, function, and physiological roles”. Pharmacological Reviews 56 (2): 231–48. DOI:10.1124/pr.56.2.3. PMID 15169928.

[pmid19519756-2] Mitchell J, Maguire J, Davenport A (June 2009). „Emerging pharmacology and physiology of neuromedin U and the structurally related peptide neuromedin S”. British Journal of Pharmacology 158 (1): 87–103. DOI:10.1111/j.1476-5381.2009.00252.x. PMC 2795236. PMID 19519756.

[pmid19324999-3] Peier A, Kosinski J, Cox-York K, Qian Y, Desai K, Feng Y, Trivedi P, Hastings N, Marsh DJ (July 2009). „The antiobesity effects of centrally administered neuromedin U and neuromedin S are mediated predominantly by the neuromedin U receptor 2 (NMUR2)”. Endocrinology 150 (7): 3101–9. DOI:10.1210/en.2008-1772. PMC 2703546. PMID 19324999.

[pmid18358099-4] Meng T, Su HR, Binkert C, Fischli W, Zhou L, Shen JK, Wang MW (April 2008). „Identification of non-peptidic neuromedin U receptor modulators by a robust homogeneous screening assay”. Acta Pharmacologica Sinica 29 (4): 517–27. DOI:10.1111/j.1745-7254.2008.00769.x. PMID 18358099.

[5] Kajino M, Hinuma S, Tarui N, Yamashita T, Nakayama Y. Receptor regulators. European Patent EP 1559428 A1. Published 03.08.2005

[pmid19369576-6] Liu JJ, Payza K, Huang J, Liu R, Chen T, Coupal M, Laird JM, Cao CQ, Butterworth J, Lapointe S, Bayrakdarian M, Trivedi S, Bostwick JR (July 2009). „Discovery and pharmacological characterization of a small-molecule antagonist at neuromedin U receptor NMUR2”. The Journal of Pharmacology and Experimental Therapeutics 330 (1): 268–75. DOI:10.1124/jpet.109.152967. PMID 19369576.

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