Best e-Prescribing Software

Compare the Top e-Prescribing Software as of November 2025

What is e-Prescribing Software?

e-Prescribing software provides physicians and medical professionals with a platform to generate and send electronic prescription orders to pharmacies and their clients. Compare and read user reviews of the best e-Prescribing software currently available using the table below. This list is updated regularly.

  • 1
    RXNT

    RXNT

    RXNT

    RXNT is an ambulatory healthcare technology pioneer that empowers medical practices and healthcare organizations to succeed and scale through innovative, data-backed, AI-powered software. Our fully-integrated, ONC-certified suite of medical software—like Clinical EHRs, Practice Management, Medical Billing and RCM, E-Prescribing, Practice Scheduling, Patient Portal, and more—optimizes clinical outcomes and RCM for your practice. Used by tens of thousands of medical professionals—from large physician practices to medical billing companies—to drive growth, streamline business operations, and improve patient care across all 50 U.S. states. Our unified “Full Suite” system employs a secure, central database so your data passes through every product in real-time from anywhere, and more than 125 million prescriptions have been transmitted and over $7 billion in claims have been processed using RXNT.
    Starting Price: $118/month
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  • 2
    ScriptSure

    ScriptSure

    DAW Systems, Inc.

    Discover the pinnacle of E-Prescribing solutions with ScriptSure Cloud ERX – the unparalleled winner of the esteemed White Coat Award for Most Accurate Prescriptions in 2021, 2022, and 2023, securing its position as an 11-time recipient of this prestigious accolade. ScriptSure Cloud ERX seamlessly integrates full e-prescribing capabilities, EPCS (controlled substance prescribing) and weekly updates to medications and daily updates to pharmacy lists. With ScriptSure you get price transparency as well; detailed costs, alternatives and ePA requirement indicators for most medications. Enjoy a user-friendly interface and streamlined workflow methods for electronic refills, order sets, compound medication ordering, prescription printing, patient reports and comprehensive audit logs. Security and compliance are paramount, with ScriptSure being fully HIPAA compliant, ensuring the confidentiality and privacy of patient data. ScriptSure is fast, accurate and built for patient safety.
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  • 3
    MedRight

    MedRight

    CareRight Technologies, LLC

    MedRight is a dynamic, user friendly, secure, cost effective software platform for use in Assisted Living communities, Residential Treatment Centers, IDD facilities, and Group Homes. MedRight improves patient safety, reduces medication errors, and is fully HIPAA compliant. Years of product enhancements and new features based on actual community use have resulted in a powerful, fully integrated software suite that users love. MedRight has it all to manage any senior living community, including the ability to work without a network connection in case the internet is down. Modules include marketing (CRM), e-prescribing, inventory, pharmacy integration, care plans, assessments, e-Narcotic logs, ADLs, billing, and resident and staff management. Let MedRight reduce your risk, improve your bottom line, and streamline your operations, while you spend more time with your residents!
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    Starting Price: $5.50/month/resident
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  • 4
    Sevocity EHR
    If you're looking for a long-term, stable EHR company that gets to know and serve you and your practice, you've come to the right place. #1 rated implementation and the only EHR that offers free ongoing customization and personalized training by practice and provider, live US-based support 24/7/365 and affordable all-inclusive pricing.
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    Starting Price: $379.00/month
  • 5
    Foothold

    Foothold

    Foothold Technology

    Our human services software offers full functionality for case management, client tracking, electronic health record (EHR), and homeless information management (HMIS) all under one roof. We work with agencies across the spectrum of human services: including developmental disabilities, mental health, substance use disorder, homelessness, supportive housing, HCBS, and much more. Foothold is HIPAA-compliant mental health software, federally certified as an EHR, and offers full interoperability as you navigate the new landscape of care coordination and value-based care. Transform the way you provide care with nimble software and a partnership guided by experience.
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    Perfect E-Prescription System
    The Perfect E-Prescription System is a sophisticated software solution designed to enhance the efficiency and safety of the prescription process in healthcare settings. By enabling healthcare providers to electronically send prescriptions directly to pharmacies, it reduces the risk of errors and ensures that patients receive their medications promptly. The system includes features for managing medication histories, checking drug interactions, and accurately dosing, which altogether streamline the prescription lifecycle. Additional functionalities include the ability to manage and authorize prescription refills, which aids in chronic disease management, and real-time tracking of prescription status, which keeps both providers and patients informed. Integration with Perfect Pharmacy Manager ensures seamless workflow between prescribing and dispensing medications, thereby optimizing operational efficiency and improving patient outcomes.
    Starting Price: $5/month
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    AZZLY

    AZZLY

    AZZLY

    AZZLY Rize is the premier clinical and business platform for addiction treatment and mental health organizations. As an all-in-one substance use disorder and mental health specific EHR, Patient Engagement and RCM platform, we serve small, medium, and large clinics. Key features for OUTPATIENT Programs include: scheduling, appointment reminder, Zoom telehealth, treatment plans, progress notes, assessments and surveys. For RESIDENTIAL programs: census, medication management, bed board, withdrawal management, DrFirst e-prescribing, EPCS, PDMP, labs. For all levels of care: alerts, patient engagement portal, electronic billing and claims submission built in. AZZLY Rize empowers your staff through its 5 star training and support services, its simplicity and automation. As a true all-in-one EHR/PM/RCM platform, improved compliance, workflow and accurate billing are achieved real-time. We proudly serve programs in over 33 states and are hosted in Microsoft Azure's private cloud network.
    Starting Price: $50/user/month
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    OptiMantra

    OptiMantra

    OptiMantra

    OptiMantra is an EMR and practice management platform focused on helping integrative and wellness practices. It serves individual and multi-modality group practices of direct and primary care providers, acupuncturists, nurse practitioners, naturopaths, chiropractors, massage therapists, PTs, dieticians and nutritionists, aesthetics, and others across the US and Canada. It is a HIPAA and PHIPA-compliant platform and is highly adaptable and robust - it includes online appointment booking, patient messaging and email reminders, a patient portal, intake forms and customizable charting, integrated payment processing, integrated labs and imaging, insurance billing, in-program tele-health, inventory management, and more. The platform is cloud-based and accessible and usable via any desktop, laptop, tablet or phone with internet access.
    Starting Price: $99 per month
  • 9
    eMedicalPractice

    eMedicalPractice

    eMedicalPractice

    eMedPractice is a cloud-based software system designed to streamline healthcare management functions. Our comprehensive solution begins with the seamless integration of our robust Electronic Health Records (EHR), Practice Management (PM) and Revenue Cycle Management (RCM) modules into one unified platform. This powerful combination of features is just the beginning. We offer a full suite of solutions and services to help you practice with efficiency and optimize workflows. Whether you're a small practice or a large healthcare organization, eMedPractice can help you save time, reduce costs, and enhance patient care. With our clinician-first software, you can manage patient data, automate administrative tasks, and improve revenue generation.
    Starting Price: $199.00/month
  • 10
    SmartChart

    SmartChart

    mumms Software

    SmartChart is mumms Software's revolutionary program for end-of-life care. mumms' focus has been solely on hospice and palliative care for the last thirty years. SmartChart was built specifically with hospice and palliative care workflows in mind, so you can focus on what you do best; quality patient care. It empowers you to make faster and better decisions as a coordinated team every day. * Hospice compliance is the foundation of SmartChart with required questions that negate double documentation * SmartChart's billing engine, ClearPay, ensures that over 99% of our agencies’ claims are accepted for reimbursement * SmartChart is a completely web-based system that is compatible with a wide array of devices * Mobile functionality for e-Prescribing, the certification process, and select documentation *Review patients in under 2 minutes or fewer in SmartChart's IDG feature *Utilize 200+ administrative, clinical, and financial reports to slice and dice your agency's data
    Starting Price: $855/month
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    PracticeHarmony

    PracticeHarmony

    Mahler Health

    Practice Harmony is the premier practice management tool for running your healthcare practice. Our cloud-based practice management software solution streamlines your practice's operations and optimizes your workflow. Robust scheduling, advanced EHR, customized forms, patient dashboard, optimized voice-to-text, full RCM, TeleMedicine, TelePsychiatry, eRx, HIPAA Compliant CRM, and so much more. Streamlined operations require the perfect orchestration of efficient patient scheduling, proper documentation, and successful billing. Run your entire practice from scheduling to billing with just one log-in. Schedule a demo today to learn how you can bring Harmony to your Practice.
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    iPrescribe

    iPrescribe

    DrFirst

    Toss your prescription pad. iPrescribe enables you to prescribe any drug from your smartphone. It’s safer and faster than your other prescribing options when you’re out of the office. The app includes access to your patient’s medication history, state PDMPs, clinical alerts, and more. Our time-tested process makes it easy to select a medication, write a prescription, sign, and send. We’ll surface popular medications and common prescriptions to get you done faster. By tapping into our network of millions of patient-prescriber relationships, iPrescribe can often automatically import your existing patients. We’ll run a check when you sign up. iPrescribe can pull a patient’s medication history from Surescripts, America’s primary e-prescribing network, and other proprietary sources at DrFirst to surface the most robust history. Just tap the Med History button in a patient’s profile.
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    Practice Mate

    Practice Mate

    Office Ally

    Practice Mate by Office Ally is a comprehensive practice management solution used by over 25,000 healthcare organizations. It simplifies revenue cycle management and assists in HIPAA-compliant recordkeeping for new and existing practices. Its user-friendly interface offers easy billing management that checks eligibility and benefits and manages claim submission and tracking. Its seamless integration with other Office Ally solutions provides additional functionality such as patient intake, reminders, e-prescriptions, and more. With no cost, commitment, or implementation, you can get started today to help reduce unnecessary administrative tasks, enhance provider job satisfaction, and improve the overall patient experience.
    Starting Price: $0
  • 14
    Wellevate

    Wellevate

    Wellevate and Emerson Ecologics

    Dispense supplements to your patients' doors, taking a margin or not. Grow your practice and make wellness accessible. We are focused on delivering the brands, resources & services to help support integrative health practitioners provide the best possible care to their patients. We're poised to offer practitioners and their patients a simpler path to lifelong wellness, reaching more people with an unmatched experience and catalog. Industry-leading virtual treatment plan tool helps you build your most comprehensive recommendations ever. Create your account, upload your certifications, and deliver simple, complete care. Make evidence-informed decisions with protocols, condition catalog search, and the ingredient library. Boost adherence with 150+ resources that you can easily attach to your treatment plans. Work from the software you already use with access to 20+ HIPAA compliant EHRs and more.
    Starting Price: Free
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    pMD

    pMD

    pMD

    End-to-end practice management and revenue cycle solutions. From patient intake to getting paid, pMD has all the software and services you need to run your medical practice. With fewer systems involved, there's less room for errors and inefficiencies. Use all of the features pMD has to offer, or we can integrate seamlessly with your existing systems. A comprehensive and secure communication strategy means fewer gaps in care and a better patient experience. Delivering the best possible care means having a standardized communication channel to connect about and with your patients. We make sure all the important patient information is accessible in one place, saving you valuable time when you need to access it. pMD offers the comprehensive, integrated, and HIPAA-compliant telemedicine platform solution health care providers need to provide unparalleled patient care. Explore all the easy-to-use telehealth software app offers and get pMD telemedicine for your practice and patients.
    Starting Price: Free
  • 16
    ViSolve OpenEMR Pro
    ViSolve specializes in providing cloud hosting services through AWS to healthcare organizations with low-cost ways to deliver their websites and web applications securely. We are one of the leading contributors of OpenEMR and has a team of expert professionals at customizing OpenEMR to allow your practice to get the most benefit from it. ViSolve is specialized in providing Health Information Exchange (HIE) through interoperability FHIR/Mirth.It includes seamless data exchange between disparate systems. The electronic medical records software that lets you chart your way in, because one-size doesn't fit all! It's a highly personal way to create optimal workflows that lets you consult more patients in an environment that fits your style. By Offering customisable solution, OpenEMR Pro is helping to fulfill vision of truly connected office, in which patients, providers and technology are connected seamlessly and exchange data with other hospitals, when required, through Mirth Connect.
    Starting Price: $99 per month
  • 17
    AdvancedMD

    AdvancedMD

    AdvancedMD

    Enjoy ease of access and security without compromise. Work remotely, see patients and stay connected with a comprehensive cloud suite of office and remote care technologies. Since 1999 we are the only medical office software built on a 100% cloud platform. We are pleased to offer our entire suite of software and data storage on the Amazon Web Services (AWS) cloud hosting platform. Combined, AdvancedMD and AWS offer an unprecedented experience with fast, reliable access to all your information, unwavering data security, and simplified storage with automatic backup. No other ambulatory software system offers this standard of hosting, which means starting or growing your practice on the cloud is as easy and affordable as it gets. Because our software is hosted and managed on AWS, as part of your low monthly subscription you get the highest levels of reliability, security and performance. Our cloud platform makes our software simple to access across multiple devices and platforms.
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    iCare

    iCare

    iCare.com

    Finally, an Electronic Health Record system for hospitals, clinics, and practices that is flexible enough to change as healthcare evolves yet doesn’t cost a fortune to implement and operate. Delivered in the cloud, the iCare Enterprise Cloud EHR is a fully integrated system which includes a full range of administrative, clinical and revenue cycle management capabilities. iCare provides a complete solution for clinical, billing and administrative functionality at a fraction of the cost of legacy software. A web-based user interface not only gives your users access to iCare from any device but it also allows the workflows to be configured to the way clinicians work. Legacy EHR systems are built on outdated client-server systems that are costly, closed, inflexible and slow to innovate. iCare is built with the future in mind. The industry’s most modern architecture, intuitive user interfaces, and rock solid performance – no other EHR comes close to iCare.
  • 19
    Juno RxTracker

    Juno RxTracker

    Document Storage Systems

    Juno RxTracker is an EPCS certified solution that boosts patient safety through an automated electronic prescription process for all medications, including controlled substances. Designed by clinicians for clinicians, Juno RxTracker offers streamlined ePrescribing for faster more intuitive workflows. For a limited time get our 1-year plan for only $596 per prescriber. Plus with free setup included, you will be up and ePrescribing in 3 easy steps! Your personal onboarding specialist will guide you through each part of the setup and will be there to help with any questions. Available on the desktop and a free app, Juno RxTracker makes it easy to prescribe from anywhere at any time! Even our subscriptions were designed with your convenience in mind. Concierge-style, pain-free set up with a dedicated onboarding specialist. The flexibility to ePrescribe from anywhere, at any time.
  • 20
    Advaa Health

    Advaa Health

    Advaa Health

    Advaa Health offers integrated medical practice software and digital health tools to help physicians deliver efficient patient care at low costs. The platform provides solutions for direct primary care, independent practice, virtual primary care, and new primary care practices. The software includes features such as electronic prescriptions, lab orders, integrated communication, patient 360 health profiles, patient portals, and revenue cycle management. It aims to reduce manual tasks, improve patient care, and enhance patient satisfaction. Physicians can focus on patient care and satisfaction while minimizing staff burnout and stress. Advaa Health emphasizes attracting, connecting, and retaining patients through a single, low-cost platform with branded, SEO-enabled websites, digital tools for patient visits, and efficient workflows.
    Starting Price: $199/month
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