Best Government e-Prescribing Software of 2025

RXNT

RXNT is an ambulatory healthcare technology pioneer that empowers medical practices and healthcare organizations to succeed and scale through innovative, data-backed, AI-powered software. Our fully-integrated, ONC-certified suite of medical software—like Clinical EHRs, Practice Management, Medical Billing and RCM, E-Prescribing, Practice Scheduling, Patient Portal, and more—optimizes clinical outcomes and RCM for your practice. Used by tens of thousands of medical professionals—from large physician practices to medical billing companies—to drive growth, streamline business operations, and improve patient care across all 50 U.S. states. Our unified “Full Suite” system employs a secure, central database so your data passes through every product in real-time from anywhere, and more than 125 million prescriptions have been transmitted and over $7 billion in claims have been processed using RXNT.

543 Ratings

Starting Price: $118/month

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ScriptSure

DAW Systems, Inc.

Discover the pinnacle of E-Prescribing solutions with ScriptSure Cloud ERX – the unparalleled winner of the esteemed White Coat Award for Most Accurate Prescriptions in 2021, 2022, and 2023, securing its position as an 11-time recipient of this prestigious accolade. ScriptSure Cloud ERX seamlessly integrates full e-prescribing capabilities, EPCS (controlled substance prescribing) and weekly updates to medications and daily updates to pharmacy lists. With ScriptSure you get price transparency as well; detailed costs, alternatives and ePA requirement indicators for most medications. Enjoy a user-friendly interface and streamlined workflow methods for electronic refills, order sets, compound medication ordering, prescription printing, patient reports and comprehensive audit logs. Security and compliance are paramount, with ScriptSure being fully HIPAA compliant, ensuring the confidentiality and privacy of patient data. ScriptSure is fast, accurate and built for patient safety.

30 Ratings

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MedRight

CareRight Technologies, LLC

MedRight is a dynamic, user friendly, secure, cost effective software platform for use in Assisted Living communities, Residential Treatment Centers, IDD facilities, and Group Homes. MedRight improves patient safety, reduces medication errors, and is fully HIPAA compliant. Years of product enhancements and new features based on actual community use have resulted in a powerful, fully integrated software suite that users love. MedRight has it all to manage any senior living community, including the ability to work without a network connection in case the internet is down. Modules include marketing (CRM), e-prescribing, inventory, pharmacy integration, care plans, assessments, e-Narcotic logs, ADLs, billing, and resident and staff management. Let MedRight reduce your risk, improve your bottom line, and streamline your operations, while you spend more time with your residents!

22 Ratings

Starting Price: $5.50/month/resident

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Foothold

Foothold Technology

Our human services software offers full functionality for case management, client tracking, electronic health record (EHR), and homeless information management (HMIS) all under one roof. We work with agencies across the spectrum of human services: including developmental disabilities, mental health, substance use disorder, homelessness, supportive housing, HCBS, and much more. Foothold is HIPAA-compliant mental health software, federally certified as an EHR, and offers full interoperability as you navigate the new landscape of care coordination and value-based care. Transform the way you provide care with nimble software and a partnership guided by experience.

2 Ratings

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Perfect E-Prescription System

SARU TECH

The Perfect E-Prescription System is a sophisticated software solution designed to enhance the efficiency and safety of the prescription process in healthcare settings. By enabling healthcare providers to electronically send prescriptions directly to pharmacies, it reduces the risk of errors and ensures that patients receive their medications promptly. The system includes features for managing medication histories, checking drug interactions, and accurately dosing, which altogether streamline the prescription lifecycle. Additional functionalities include the ability to manage and authorize prescription refills, which aids in chronic disease management, and real-time tracking of prescription status, which keeps both providers and patients informed. Integration with Perfect Pharmacy Manager ensures seamless workflow between prescribing and dispensing medications, thereby optimizing operational efficiency and improving patient outcomes.

Starting Price: $5/month

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AZZLY

AZZLY Rize is the premier clinical and business platform for addiction treatment and mental health organizations. As an all-in-one substance use disorder and mental health specific EHR, Patient Engagement and RCM platform, we serve small, medium, and large clinics. Key features for OUTPATIENT Programs include: scheduling, appointment reminder, Zoom telehealth, treatment plans, progress notes, assessments and surveys. For RESIDENTIAL programs: census, medication management, bed board, withdrawal management, DrFirst e-prescribing, EPCS, PDMP, labs. For all levels of care: alerts, patient engagement portal, electronic billing and claims submission built in. AZZLY Rize empowers your staff through its 5 star training and support services, its simplicity and automation. As a true all-in-one EHR/PM/RCM platform, improved compliance, workflow and accurate billing are achieved real-time. We proudly serve programs in over 33 states and are hosted in Microsoft Azure's private cloud network.

3 Ratings

Starting Price: $50/user/month

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SmartChart

mumms Software

SmartChart is mumms Software's revolutionary program for end-of-life care. mumms' focus has been solely on hospice and palliative care for the last thirty years. SmartChart was built specifically with hospice and palliative care workflows in mind, so you can focus on what you do best; quality patient care. It empowers you to make faster and better decisions as a coordinated team every day. * Hospice compliance is the foundation of SmartChart with required questions that negate double documentation * SmartChart's billing engine, ClearPay, ensures that over 99% of our agencies’ claims are accepted for reimbursement * SmartChart is a completely web-based system that is compatible with a wide array of devices * Mobile functionality for e-Prescribing, the certification process, and select documentation *Review patients in under 2 minutes or fewer in SmartChart's IDG feature *Utilize 200+ administrative, clinical, and financial reports to slice and dice your agency's data

2 Ratings

Starting Price: $855/month

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PracticeHarmony

Mahler Health

Practice Harmony is the premier practice management tool for running your healthcare practice. Our cloud-based practice management software solution streamlines your practice's operations and optimizes your workflow. Robust scheduling, advanced EHR, customized forms, patient dashboard, optimized voice-to-text, full RCM, TeleMedicine, TelePsychiatry, eRx, HIPAA Compliant CRM, and so much more. Streamlined operations require the perfect orchestration of efficient patient scheduling, proper documentation, and successful billing. Run your entire practice from scheduling to billing with just one log-in. Schedule a demo today to learn how you can bring Harmony to your Practice.

1 Rating

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Veradigm ePrescribe

Veradigm

Veradigm ePrescribe is a comprehensive, easy-to-use solution for electronic prescribing, designed to ensure you and your patients are covered every step of the way. Whether you are looking for low-cost e-prescribing to save you time and free you from your script pad forever, or advanced e-prescribing with all the latest features that keep you up to date with regulatory mandates, Veradigm ePrescribe is the proven choice used by over 140,000 prescribers for hundreds of millions of transactions every year. Save time by prescribing electronically within your clinical workflow. Drive improvements in medication adherence, satisfaction, and efficiency. e-prescribe from anywhere you have internet access, including your mobile device. Far beyond streamlining prescribing and helping you eliminate calls and faxes, Veradigm ePrescribe delivers patients’ medication histories and formularies, automatic interaction checks, and the advanced e-prescribing capabilities you need.

2 Ratings

Starting Price: $59 per month

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iPrescribe

DrFirst

Toss your prescription pad. iPrescribe enables you to prescribe any drug from your smartphone. It’s safer and faster than your other prescribing options when you’re out of the office. The app includes access to your patient’s medication history, state PDMPs, clinical alerts, and more. Our time-tested process makes it easy to select a medication, write a prescription, sign, and send. We’ll surface popular medications and common prescriptions to get you done faster. By tapping into our network of millions of patient-prescriber relationships, iPrescribe can often automatically import your existing patients. We’ll run a check when you sign up. iPrescribe can pull a patient’s medication history from Surescripts, America’s primary e-prescribing network, and other proprietary sources at DrFirst to surface the most robust history. Just tap the Med History button in a patient’s profile.

9 Ratings

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Practice Mate

Office Ally

Practice Mate by Office Ally is a comprehensive practice management solution used by over 25,000 healthcare organizations. It simplifies revenue cycle management and assists in HIPAA-compliant recordkeeping for new and existing practices. Its user-friendly interface offers easy billing management that checks eligibility and benefits and manages claim submission and tracking. Its seamless integration with other Office Ally solutions provides additional functionality such as patient intake, reminders, e-prescriptions, and more. With no cost, commitment, or implementation, you can get started today to help reduce unnecessary administrative tasks, enhance provider job satisfaction, and improve the overall patient experience.

Starting Price: $0

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CarePaths EHR

CarePaths

We built CarePaths EHR for psychiatrists, psychologists, social workers, and counselors to affordably manage practices of all sizes. We are a HIPAA Compliant and ONC-Certified, fully integrated cloud-based behavioral electronic health record and practice management platform. Our system also includes online therapy with secure texting, teletherapy, and outcomes monitoring. With the free upgrade to CarePaths Connect, clinicians can also create a Digital Front Door, allowing patients to effortlessly sign up for services and book appointments with the CarePaths Connect mobile app for patients. Patients can also use the app to engage in teletherapy, message their therapist, and complete assessments. The Automated Measurement-Based Care (MBC) feature streamlines the process of outcomes monitoring so clinicians can tailor their approach based on patient feedback for better therapy outcomes.

Starting Price: $49 per user per month

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EazyScripts

eazyScripts

Help patients discover and take advantage of prescription cost savings during the encounter. Take The Stress and Difficulty Out of Your Transition to ePrescribing. We Make It Eazy! ePrescribing is mandated in 24 states currently and will be required in yours soon, get ahead of the curve and enroll today. Secure, cloud-based, & HIPAA compliant.

Starting Price: $39.95 per month

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Ayfa iClinic

Medical Software that organizes and streamlines your clinic. Have more practicality in your daily life with the software for clinics easier to use. Ayfa iClinic Teleconsultation. Orient your patients even from a distance iClinic Marketing. Send campaigns and email streams. Online Agenda. Access your medical schedule from anywhere. Customizable Medical Record. Leave your electronic medical record your way. We want your clinic to be as successful as you are. Ayfa iClinic is not just a system, we help you at all times of your day to day. Service agility. Quick support and tips to optimize your clinic. Access from anywhere. 00% data in the cloud, accessible from all devices. Bank security level. All data is encrypted and secure. Day-to-day practicality. UX team that produces the easiest-to-use system in Brazil. We have already helped over 70 thousand professionals in 22 countries and in all states of Brazil. Practically prove why Ayfa iClinic is more economical than staying on paper

Starting Price: $79 per user, per month

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Wellevate

Wellevate and Emerson Ecologics

Dispense supplements to your patients' doors, taking a margin or not. Grow your practice and make wellness accessible. We are focused on delivering the brands, resources & services to help support integrative health practitioners provide the best possible care to their patients. We're poised to offer practitioners and their patients a simpler path to lifelong wellness, reaching more people with an unmatched experience and catalog. Industry-leading virtual treatment plan tool helps you build your most comprehensive recommendations ever. Create your account, upload your certifications, and deliver simple, complete care. Make evidence-informed decisions with protocols, condition catalog search, and the ingredient library. Boost adherence with 150+ resources that you can easily attach to your treatment plans. Work from the software you already use with access to 20+ HIPAA compliant EHRs and more.

Starting Price: Free

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pMD

End-to-end practice management and revenue cycle solutions. From patient intake to getting paid, pMD has all the software and services you need to run your medical practice. With fewer systems involved, there's less room for errors and inefficiencies. Use all of the features pMD has to offer, or we can integrate seamlessly with your existing systems. A comprehensive and secure communication strategy means fewer gaps in care and a better patient experience. Delivering the best possible care means having a standardized communication channel to connect about and with your patients. We make sure all the important patient information is accessible in one place, saving you valuable time when you need to access it. pMD offers the comprehensive, integrated, and HIPAA-compliant telemedicine platform solution health care providers need to provide unparalleled patient care. Explore all the easy-to-use telehealth software app offers and get pMD telemedicine for your practice and patients.

Starting Price: Free

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Osmind

Osmind simplifies mental health treatment workflows and improves the patient experience. Our platform is an all-in-one solution that saves you time and maximizes your impact, all at an affordable price. Stop wasting time on a complex EHR that requires endless clicks and extensive workflows. Osmind was built by psychiatrists with mental health practices in mind. The Osmind EHR is ready for the breakthrough mental health treatments of tomorrow. Easily manage medications, and administer interventions like TMS, ketamine, SPRAVATO®, or psychedelic medicine. Provide a modern patient experience that improves patient engagement and satisfaction. Your patients will have access to an easy-to-use mobile app to track their progress, securely communicate, and submit out-of-network claims. Run your practice your way with flexible scheduling, virtual visits, and payments all in one place. Reduce your overhead and improve cashflow, so you can get back to focusing on your patients.

Starting Price: Free

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DigitalRX.io

DigitalRX.io offers a white-labeled software solution for clinics and healthcare professionals to create customized websites and apps in just 24 hours. Our solution offers a branded clinic website, a branded clinic app, a doctor app, and a clinic admin portal all with amazing features designed to help healthcare professionals succeed in their online healthcare journey. With DigitalRX, healthcare providers can reach more patients, provide better care, and have a strong online presence in today's healthcare landscape. The dedicated Clinic website and App enables patients to conveniently book appointments for clinic visits or book online consultations with doctors. It provides patients with convenient access to a spectrum of healthcare services offered by the clinics. Doctor app is a helpful tool that allows doctors to plan and track their schedules easily and enables them to provide convenient telehealth services. Admin Portal helps in organizing and improving clinic's daily tasks.

Starting Price: $50/month

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DocVilla

PS3G

DocVilla is a comprehensive, multi-specialty, mobile-friendly, HIPAA-compliant cloud-based health technology platform that integrates EHR/EMR, telehealth, e-prescribing, patient engagement, medical billing, analytics and reporting, direct primary care, inventory management, remote patient monitoring, and more into a unified, configurable suite. Providers simply sign in to access a customizable electronic medical records system with secure messaging, video visits, controlled-substance e-Rx, and a free patient portal for scheduling, payment, and secure communications. The platform streamlines workflows by automating eligibility checks, claim submissions, charge posting, insurance eligibility and claim filing, ERAs/EOBs, medical dictation and speech-to-text, patient consent forms, lab integrations, electronic fax, and automatic appointment reminders.

Starting Price: $100 per month

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DrChrono

Increase the efficiency of your medical practice with an all-in-one practice management, electronic health records, and medical billing platform from DrChrono. With its modern and simple interface and dozens of advanced features, DrChrono empowers medical practitioners to better serve their patients. Users can easily schedule patient appointments, check and edit patient charts, and manage billing with ease.

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ViSolve OpenEMR Pro

ViSolve

ViSolve specializes in providing cloud hosting services through AWS to healthcare organizations with low-cost ways to deliver their websites and web applications securely. We are one of the leading contributors of OpenEMR and has a team of expert professionals at customizing OpenEMR to allow your practice to get the most benefit from it. ViSolve is specialized in providing Health Information Exchange (HIE) through interoperability FHIR/Mirth.It includes seamless data exchange between disparate systems. The electronic medical records software that lets you chart your way in, because one-size doesn't fit all! It's a highly personal way to create optimal workflows that lets you consult more patients in an environment that fits your style. By Offering customisable solution, OpenEMR Pro is helping to fulfill vision of truly connected office, in which patients, providers and technology are connected seamlessly and exchange data with other hospitals, when required, through Mirth Connect.

Starting Price: $99 per month

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AdvancedMD

Enjoy ease of access and security without compromise. Work remotely, see patients and stay connected with a comprehensive cloud suite of office and remote care technologies. Since 1999 we are the only medical office software built on a 100% cloud platform. We are pleased to offer our entire suite of software and data storage on the Amazon Web Services (AWS) cloud hosting platform. Combined, AdvancedMD and AWS offer an unprecedented experience with fast, reliable access to all your information, unwavering data security, and simplified storage with automatic backup. No other ambulatory software system offers this standard of hosting, which means starting or growing your practice on the cloud is as easy and affordable as it gets. Because our software is hosted and managed on AWS, as part of your low monthly subscription you get the highest levels of reliability, security and performance. Our cloud platform makes our software simple to access across multiple devices and platforms.

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Treat

DoseSpot

Treat 4 advances e-prescribing to a new level of power and convenience. Experience Treat on any device with a refined mobile experience. Discover new features like Real-Time Prescription Benefits and Eligibility. Send prescriptions from your desktop or mobile device with Treat 4, giving you the power and flexibility to care for your patients, wherever they may be. It’s never been easier to send and manage electronic prescriptions. Treat 4 offers a robust set of e‑prescribing features to accelerate your workflow. All accessible from your favorite device. Treat 4’s intuitive workflow makes electronic prescribing an asset instead of a distraction. A streamlined design is informed by a sharpened focus on efficiency when writing prescriptions. Your most frequently prescribed medications can be saved as favorites, accessible when and where you need them. Treat 4 is accessible from any web browser as a standalone e‑prescribing app.

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DENmaar Guardian

DENmaar

The DENmaar Guardian will allow you to check on the status and explore many features. The DENmaar Guardian offers a suite of services designed to improve and provide measurable financial results. From insurance credentialing and billing to our advanced automated RCM, our behavioral and mental health providers can be assured of optimal economic outcomes. Patient scheduling is critical for operational efficiency, reducing missed visits, and ensuring that patients are seen promptly. The DENmaar scheduler offers several key features that you should look for when analyzing the quality of a patient scheduling system. Stay HIPAA compliant while collecting payment using DENpay. Practitioners must keep their patient's medical, financial, and personal information safely secured.  Patients continue to carry an increased burden of deductibles, premiums, and other medical expenses. Advanced yet user-friendly medical EHR software specifically designed for behavioral healthcare.

Starting Price: Free

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ChartLogic

Medsphere Systems

Enhance patient care, office efficiency, and profitability with ChartLogic, an integrated Electronic Health Record (EHR) software suite for private physician practices. Designed to intuitively match a practice's workflow, as well as its specialty and personal preferences, ChartLogic EHR helps physicians document patient encounters and store information securely and cost-effectively. ChartLogic EHR suite includes Electronic Medical Record (EMR) tools, practice management, and medical billing services.

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OrderConnect

Netsmart Technologies

OrderConnect™ is a web-based electronic prescribing and medication management tool that allows providers to prescribe, review and order tests electronically. While integrated with Netsmart electronic health records (EHRs), it can be used as a stand-alone solution as well. OrderConnect is an Electronic Prescribing of Controlled Substances (EPCS) certified solution that supports prescribers in states that mandate EPCS when prescribing opioids and other controlled substances. Access Prescription Drug Monitoring Programs (PDMPs) during the prescribing process. The tool provides support to prescribers in many states that mandate PDMP checking before prescribing opioids and other controlled substances.

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Nexus EHR

Nexus Clinical

Nexus EHR is a cloud-based EHR and PM platform for clinical healthcare providers. Our EHR works with your clinical workflow and maximizes the physician-patient encounter. Access anywhere, any time, and with any device (PC, Tablet, Mobile). Breeze through encounters via our intuitive, easy-to-use interface that allows you to practice naturally. Multi-modal data input allows for maximum flexibility. Nexus Practice Management systems help you manage all billing activities, claims, and ERAs to maximize your revenues. Nexus EHR offers telemedicine to connect with your patients remotely. Nexus's Patient portal offers great flexibility to patients to fill all the demographics, insurance information, and histories online at their convenience.

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SoftClinic GenX

JVS Group

SoftClinic is the best hospital management software used by 25000+ physicians in 45+ countries. It is a fully paperless system to reduce clerical errors and ensure the integrity of medical data. The software has integrated features such as EHR, pharmacy, Inventory Management, attendance, and lab management.

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MDToolbox e-Prescribing

MDToolbox

MDToolbox-Rx is a Certified, Award-Winning, complete electronic prescription writer that can run stand-alone or synced with your other office software. The e-Prescribing Software is a highly customizable, simple to use e-prescribing system that allows you to easily select drugs, find drug information, and create and electronically send a prescription quickly and efficiently. MDToolbox-Rx is Certified for e-Prescribing, Eligibility, Formulary, EPCS (e-Prescribing of Controlled Substances), and Electronic Prior Authorization. Search for drugs by name, nickname, generic, brand, rx, OTC, class or indication in the most comprehensive drug database available. Higher productivity due to less pharmacy calls and time spent for renewal requests.

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iCare

iCare.com

Finally, an Electronic Health Record system for hospitals, clinics, and practices that is flexible enough to change as healthcare evolves yet doesn’t cost a fortune to implement and operate. Delivered in the cloud, the iCare Enterprise Cloud EHR is a fully integrated system which includes a full range of administrative, clinical and revenue cycle management capabilities. iCare provides a complete solution for clinical, billing and administrative functionality at a fraction of the cost of legacy software. A web-based user interface not only gives your users access to iCare from any device but it also allows the workflows to be configured to the way clinicians work. Legacy EHR systems are built on outdated client-server systems that are costly, closed, inflexible and slow to innovate. iCare is built with the future in mind. The industry’s most modern architecture, intuitive user interfaces, and rock solid performance – no other EHR comes close to iCare.

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Best Government e-Prescribing Software

Compare the Top Government e-Prescribing Software as of November 2025

What is Government e-Prescribing Software?