Compare the Top SPC Software in the USA as of November 2025

What is SPC Software in the USA?

Statistical process control (SPC) software allows manufacturing companies to streamline the management, comparison and analysis of statistical data in order to optimize performance and make predictions. Compare and read user reviews of the best SPC software in the USA currently available using the table below. This list is updated regularly.

  • 1
    MasterControl

    MasterControl

    MasterControl

    Bringing breakthrough products to market in highly regulated industries can feel like an endless series of trade-offs. MasterControl's software simplifies GxP workflows so you never have to sacrifice quality for cost or innovation for regulation. Complete and connected meets fast and flexible. From quality event management to document control and integrated training - MasterControl Quality Excellence transforms your quality data and processes into a competitive advantage. Modernizing your manufacturing operations starts with modern software. From work orders to work instructions and production records (EBR or eDHR) to logbooks, MasterControl Manufacturing Excellence is the simplest way to digitalize manufacturing.
    Starting Price: $25,000 / 1st year
  • 2
    SafetyChain

    SafetyChain

    SafetyChain Software

    SafetyChain is the #1 Plant Management Platform that improves yield, maximizes productivity, and ensures compliance for process manufacturers. Trusted by over 1,500 facilities, SafetyChain is the only enterprise solution uniting production, quality, safety, and supplier management.
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