CP-94,253
| IUPAC ime | |
|---|---|
3-(1,2,5,6-tetrahidro-4-piridil)-5-propoksipirolo[3,2-b]piridin | |
| Identifikatori | |
| CAS broj | 131084-35-0 |
| ATC kod | none |
| PubChem | CID 4029677 |
| Hemijski podaci | |
| Formula | C15H19N3O |
| Molarna masa | 257,330 g/mol |
| |
CP-94,253 je lek koji deluje kao potentan i selektivan agonist serotoninskog 5-HT1B receptora, sa približno 25x i 40x selektivnošću u odnosu na blisko srodne 5-HT1D i 5-HT1A receptore.[1] On pokazuje opseg biheviouralnih efekata u životinjskim studijama, uključujući promovisanje budnosti putem povećanja dopaminskog otpuštanja u mozgu,[2][3] redukovanje unosa hrane i povećanja sitosti,[4][5][6] pojačanja dejstva kokaina,[7][8][9][10] kao i moguće antidepresivno dejstvo.[11]
Reference
[уреди | уреди извор]- ^ Koe, K. B.; Nielsen, J. A.; Macor, J. E.; Heym, J. (1992). „Biochemical and behavioral studies of the 5-HT1B receptor agonist, CP-94,253”. Drug Development Research. 26 (3): 241—250. doi:10.1002/ddr.430260305.
- ^ Monti, J. M.; Monti, D; Jantos, H.; Ponzoni, A. (децембар 1995). „Effects of selective activation of the 5-HT1B receptor with CP-94,253 on sleep and wakefulness in the rat”. Neuropharmacology. 34 (12): 1647—51. PMID 8788962.
- ^ Iyer, R. N.; Bradberry, C. W. (април 1996). „Serotonin-mediated increase in prefrontal cortex dopamine release: pharmacological characterization”. Journal of Pharmacology and Experimental Therapeutics. 277 (1): 40—7. PMID 8613947.
- ^ Halford, J. C.; Blundell, J. E. (септембар 1996). „The 5-HT1B receptor agonist CP-94,253 reduces food intake and preserves the behavioural satiety sequence”. Physiology and Behaviour. 60 (3): 933—9. PMID 8873272.
- ^ Lee, M. D.; Simansky, K. J. (јун 1997). „CP-94,253: a selective serotonin1B (5-HT1B) agonist that promotes satiety”. Psychopharmacology (Berlin). 131 (3): 264—70. PMID 9203237.
- ^ Lee MD, Kennett GA, Dourish CT, Clifton PG (октобар 2002). „5-HT1B receptors modulate components of satiety in the rat: behavioural and pharmacological analyses of the selective serotonin1B agonist CP-94,253”. Psychopharmacology (Berlin). 164 (1): 49—60. PMID 12373419.
- ^ Parsons, L. H.; Weiss, F.; Koob, G. F. (децембар 1998). „Serotonin1B receptor stimulation enhances cocaine reinforcement”. Journal of Neuroscience. 18 (23): 10078—89. PMID 9822762.
- ^ Przegalinski E, Filip M, Papla I, Siwanowicz J (април 2001). „Effect of serotonin (5-HT)1B receptor ligands on cocaine sensitization in rats”. Behavioural Pharmacology. 12 (2): 109—16. PMID 11396515.
- ^ Przegaliński E, Gołda A, Frankowska M, Zaniewska M, Filip M (2007). „Effects of serotonin 5-HT1B receptor ligands on the cocaine- and food-maintained self-administration in rats”. European Journal of Pharmacology. 559 (2-3): 165—72. PMID 17291490. doi:10.1016/j.ejphar.2006.12.012.
- ^ Przegaliński E, Gołda A, Filip M (2008). „Effects of serotonin (5-HT)(1B) receptor ligands on cocaine-seeking behavior in rats”. Pharmacological Reports : PR. 60 (6): 798—810. PMID 19211971.
- ^ Tatarczyńska E, Antkiewicz-Michaluk L, Kłodzińska A, Stachowicz K, Chojnacka-Wójcik E. „Antidepressant-like effect of the selective 5-HT1B receptor agonist CP 94253: a possible mechanism of action”. European Journal of Pharmacology. 516 (1): 46—50. мај 2005. PMID 15913599.