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- DirectorDavid SemelStarsHugh LaurieLisa EdelsteinOmar EppsChaos ensues after Chase's negligence leads to the death of a female patient. Now, after an inquiry from the hospital board, and a subpoena from the patient's brother, it's up to Stacey to protect Chase's career, as well as House's.
- DirectorBill JohnsonStarsHugh LaurieLisa EdelsteinOmar EppsWhile House and his team scramble to discover what's causing brain and kidney dysfunction in a pregnant woman, Vogler is on the warpath to get House fired.
- DirectorDavid StraitonStarsHugh LaurieLisa EdelsteinOmar EppsForeman hires Chase and Cameron as his new team. An African tyrant becomes Foreman and co.'s patient. They're not happy. House is back as consultant. House meets Wilson's downstairs neighbor.
- DirectorDavid PlattStarsHugh LaurieLisa EdelsteinOmar EppsHouse tries every delaying tactic available when Wilson forces him to attend his father's funeral. Meanwhile, the team tries to find the cause of a young woman's abdominal pain and hemorrhage that occurred in China.
- DirectorDeran SarafianStarsHugh LaurieLisa EdelsteinOmar EppsHouse is off his game without the team, and Wilson uses an extreme tactic to force him into interviews.
- DirectorElodie KeeneStarsHugh LaurieLisa EdelsteinOmar EppsHouse and Cuddy are flying back to the US from an international conference in Singapore. While en route a mysterious disease strikes one passenger and an epidemic unfolds, causing House to diagnose in midair since they have missed the halfway mark by passing the north pole. Back in Princeton, Wilson and House's lackeys have a confusing case of what is ailing a woman who came into the clinic and proceeded to have a seizure.
- DirectorNewton Thomas SigelStarsHugh LaurieLisa EdelsteinOmar EppsA ten-year-old boy begins screaming in pain, but nobody knows why, because he is autistic and cannot explain. House refuses to use his office because it has new carpet.
- DirectorFred GerberStarsHugh LaurieLisa EdelsteinOmar EppsOn a class field trip, a teacher discovers that her six-year-old student, Ian, is bleeding profusely. Dr. House thinks Ian has the same unknown disease that killed an elderly patient of his years ago.
- DirectorMiguel SapochnikStarsHugh LaurieOmar EppsRobert Sean LeonardA patient's illness has its roots in the body and mind. Wilson and House try to come to terms with the cancer.
- DirectorHugh LaurieStarsHugh LaurieOmar EppsRobert Sean Leonard6 y.o. Emily gets a nose bleed and faints. Her dad gets her to the hospital, her mom's a doctor. Wilson has cancer, House is there for him.
- DirectorGreg YaitanesStarsHugh LaurieLisa EdelsteinOmar EppsHouse's Amber hallucination becomes more aggressive as sleep deprivation takes its toll endangering a patient, and Chase's bachelor party ends in the emergency room.
- CreatorDavid ShoreStarsHugh LaurieOmar EppsRobert Sean LeonardUsing a crack team of doctors and his wits, an antisocial maverick doctor specializing in diagnostic medicine does whatever it takes to solve puzzling cases that come his way.
- DirectorKatie JacobsStarsHugh LaurieLisa EdelsteinOmar EppsHouse struggles to find out why a pianist savant is losing his ability to play. Ultimately, a decision must be made as to how much brain is necessary for a normal quality of life.
- DirectorJuan José CampanellaStarsHugh LaurieLisa EdelsteinOmar EppsStuck with clinic duty, House almost wishes he had the boring patients back after he encounters a young woman with an STD and the need to talk.
- DirectorDeran SarafianStarsHugh LaurieLisa EdelsteinOmar EppsA police officer in critical condition has bizarre symptoms, and Dr. Foreman finds himself in an unpleasant situation.
- DirectorGreg YaitanesStarsHugh LaurieOmar EppsRobert Sean LeonardWhen a violent incident involving a patient has serious consequences for one staff member, House and the team are placed under review by Dr. Walter Cofield, Foreman's former mentor and current Chief of Neurology. As House and each member of his team recount the details of the dramatic and life-threatening incident, Cofield must weigh the team's unconventional brand of collaboration against their ability to save lives.
- DirectorMiguel SapochnikStarsHugh LaurieLisa EdelsteinOmar EppsDarrien steals a car after getting stabbed and hurries to her friend 13's home for help. Chase brings an ultrasound and helps. House performs surgery on his own leg at home after using experimental drugs.
- DirectorGreg YaitanesStarsHugh LaurieLisa EdelsteinOmar EppsTaub treats a patient whose dying husband gets better as she becomes sicker, while the rest of the team deals with a devastating loss.
- DirectorDaniel AttiasStarsHugh LaurieLisa EdelsteinOmar EppsHouse is injured in a motorcycle accident. While recovering, he finds an accident victim suffering from a brain injury. House tries to prove the brain damage caused the accident, not vice versa, so he can treat the patient.
- DirectorDavid StraitonStarsHugh LaurieLisa EdelsteinOmar EppsWhen a researcher at a South Pole base becomes ill, House must diagnose the case at a distance. Meanwhile, House tries to find out who Wilson is dating, and his new staff tries to get him cable.
- DirectorDeran SarafianStarsHugh LaurieLisa EdelsteinOmar EppsA very brave and mature 9-year-old girl has terminal cancer, but that is not what the problem seems to be.
- DirectorDavid ShoreStarsHugh LaurieOmar EppsRobert Sean LeonardTreating a drug addict patient results in House examining his life, his future and confronting his own personal demons.
- DirectorDavid StraitonStarsHugh LaurieLisa EdelsteinOmar EppsWhen all of House's efforts to rid himself of Amber fail, he turns to someone unexpected for assistance. Meanwhile, the team is left to fend for itself as they try to save a ballerina's life and career.
- DirectorDeran SarafianStarsHugh LaurieLisa EdelsteinOmar EppsHouse tries radical procedures to save Foreman's life; Foreman's father visits.
- DirectorDavid ShoreStarsHugh LaurieLisa EdelsteinOmar EppsAn old patient of House comes back and seeks revenge upon him in the form of gunshot.