Katherine Dooley (Jeremy's wife who he called towards the end of the movie), was played by Jeremy's real-life wife, Katherine Dooley.
Uno: The Movie is a direct sequel to the independent short film "Let's Play - Uno." Though the setup and atmosphere are similar, Uno: The Movie expands on many of its predecessors ideas in both scope and scale.
Ryan Haywood left the project halfway through filming, citing family responsibilities. The remainder of his part was completed by his long-time voice double, Jack Pattillo.
Principal photography for Uno: The Movie began on the night of the 2016 United States Presidential Election. It is speculated the use of a presidential election within the narrative was likely inspired by this real-life event.
Uno: The Movie is the third longest production released by Achievement Hunter, beaten only by the Mario Party 8: 50-Turn Extra Life Extravaganza and Mario Party 5: 50-turn extravaganza with the latter being the longest.