Trivia

Dee Dee only spoken line in the film is her catchphrase, "Oooh, what does this button do?"

Intended to be the series finale of Dexter's Laboratory (1996), creator Genndy Tartakovsky left the series to work on other projects such as Samurai Jack (2001) and Star Wars: Clone Wars (2003). Due to the series' popularity, writer and storyboard artist Chris Savino revived the series for a third and fourth season from late 2001 until 2003.

Dexter's third chronological incarnation is the only Dexter not voiced by Christine Cavanaugh.

This is the final installment of the series to use traditional cel animation. Digital coloring began with the revived series in 2001, starting with Streaky Clean/A Dad Cartoon/Sole Brother (2001).

This is the first and only movie co-produced by Cartoon Network Studios and Hanna-Barbera.