cobas® 6000 analyzer series

Flexibility you can build on

cobas® brand

Roche introduces the cobas® brand as the umbrella for products cobas brand includes:
used to complete or expand the screening, diagnostic and moni- Serum work area with clinical chemisty
toring applications of the professional laboratory. and immunochemistry
Data management and preanalytical solutions
Products for coagulation analysis and urinalysis
Instruments for rapid blood and
cardiovascular testing
PCR-based applications for virology
and women’s health testing
cobas® modular platform
Flexibility you can build on

Today’s laboratories are challenged with delivering high stan- Common reagent concept
dards of laboratory services with fewer resources. They face
constant pressure to lower operating costs while aspiring to Simplifies logistics
grow their business in new areas. Their concern for patient care Allows efficient use of reagents
is paramount, and they demand only the best in diagnostic
testing and services.
Common applications
Just as every patient requires individualized care, every labo- and analytical technologies
ratory is unique. Striking the balance between high standards
and efficient operation requires tailor-made solutions. With Ensures comparable patient results
cobas® modular platform, Roche has developed a platform Combines routine and innovative testing
concept that delivers individualized solutions based on a
common architecture for various workloads and testing
requirements. Common operator interface

cobas® 6000 analyzer series is a member of the cobas modular Requires less training
platform. It offers medium workload laboratories tailor-made Promotes staff flexibility
solutions for clinical chemistry and immunochemistry testing.
The cobas modular platform is designed to reduce the com-
plexity of laboratory operation and provides efficient and
compatible solutions for network cooperation.
cobas® 6000 analyzer series
A new generation of modularity

Efficiency Convenience

More than 160 assays on a single platform Ready-to-use liquid reagents

Innovative reagent concept Long on-board stability, up to three months
Dedicated STAT port Loading “on the fly”
Automatic rerun and reflex testing* Single sample tube handling
*supported by LIS
>> Diese beiden Seiten werden verkürzt und eingeklappt – deckungsgleich mit dem Innenteil

Quality Safety

Electrochemiluminiscence (ECL) technology Automatic clot & level detection

Consistent reagent formulation across systems Disposable tips for carry over protection
Proven Hitachi reliability Contact-free ultrasonic mixing
Standardized and traceable high quality reagents Serum indices
 One platform, seven configurations
Consolidation with customized flexibility
Broad menu with more than 160 assays supporting consolidation of more
than 95% of routine workflow
One system interface, one sample entry, one sample tube for more efficient
testing and less hands on time
Scaleable configurations with seamless integration of pre-analytical
automation addressing changing needs with superior flexibility

cobas c pack & cobas e pack

The unique reagent concept
Liquid ready to use reagents reducing
hands on time and potential errors
Optimized kit sizes with high on-board
stability improving test yield with less
operator interventions and wastage
Innovative carrier concept simplifying
logistics incl. reduced storage and
inventory requirements

ECL (Electrochemiluminiscence) Technology

The key for high quality results the first time
Broad measuring range eliminating unnecessary reruns, saving time and
money
High precision and excellent low end sensitivity leading to better clinical
decisions and improved patient care
Short turnaround time facilitating fast response without compromising the
analytical quality
cobas® 6000 analyzer series
True workload consolidation

Core Unit cobas c 501 module

Loading capacity of 150 Clinical chemistry, ISE (K, Na, Cl),

samples in two trays of 75 over 100 Homogeneous Immunoassays,
Load 5-position racks via HbA1c (whole blood measurement)
dedicated STAT port with Throughput of up to 1000 tests/hour
rerun buffer or by tray 60 direct-access assays
Simple operation with contin- Automatic reagent loading during operation
uous loading and unloading Specimen integrity via serum indices, clot and
liquid level detection
Contact free ultrasonic mixing
 cobas e 601 module

Heterogeneous Immunoassays,
NT-proBNP, Troponin T and other cardiac
markers and
over 60 assays for anemia, bone and tumor
markers, hormones, and infectious diseases
Throughput of up to 170 tests/hour
25 direct-access assays
Carry-over free disposable tips
Clot and liquid level detection
Dedicated STAT port
True STAT capabilities for immediate processing
STAT samples processed within 60 seconds upon entry providing faster
turnaround time and reporting on high-priority samples
Samples entering the STAT port are transported directly to the Smart Track Rotor

Smart Track Rotor

Managing optimal sample workflows
Intelligent sample processing enabling most efficient system operation in
real-time
Sample routing automatically controlled by Intelligent Process Management
(IPM) featuring rerun or reflex testing as well as carry-over evasion management
Rotor design and intelligent sample routing supporting true STAT prioritization
whenever needed

cobas® link
The secure gateway connection to Roche
Secure connectivity between the laboratory and Roche
Access to advanced cobas® e-services featuring value added services to the
laboratory business

cobas® e-services
Lab intelligence at your fingertips
cobas® e-support – immediate trouble shooting via remote access improving
system uptime and operative efficiency
cobas® e-library – automatic update functionality safeguarding online access
to most recent application information on reagents, calibrators and controls
cobas® e-LabPerformance* – offering advanced performance monitoring
tools for efficient QC management * in preparation
MODULAR PRE-ANALAYTICS EVO
Optimizing workflow efficiency
Proven and reliable Total Lab Automation* with expert
consultancy services:

Compact configurations and flexible design ensuring

connection to cobas® 6000 analyzer series in almost every
laboratory environment
Centrifugation, decapping, aliquotting, labeling, recapping
and sorting functionalities reducing manual tasks and
overall process complexity
Support of primary as well as secondary workflow handling
featuring standardized processes with shorter and more
predictable turnaround times
* automatic storage and retrieval module in development

cobas IT 3000 solution

Comprehensive standardization and
integration of data management
One work area management tool extending capabilities of
most laboratory information systems:

Reducing variability through consistency in decision

management
Increasing efficiency by comprehensive workflow tools
Active management of results and patient data providing
optimal information management for physicians
04772016001햵 - 0708 - 2.0 WW

COBAS, COBAS C, COBAS E, MODULAR and

LIFE NEEDS ANSWERS are trademarks of Roche.

Windows XP is a trademark of Microsoft Corporation.

Pentium is a trademark of Intel Corporation.

©2008 Roche

Roche Diagnostics Ltd.

CH-6343 Rotkreuz
Switzerland
www.roche.com
cobas® 6000 analyzer series
Technical specifications
System 2nd Generation SWA: modular, analytical system platform, consolidated work area for
Clinical Chemistry and Immunology, expandable and re-configurable on site
System components Control Unit: PC, monitor, keyboard, printer, etc. on an ergonomic stand
Core Unit: Sample input/output, sample transport by Intelligent
Process Management
Analytical modules: 2 analytical modules
Type of modules cobas c 501 module: Photometric measuring unit (incl. ISE)
cobas e 601 module: ECL technology measuring unit
Number of module 7 module combinations
combinations Up to 3 modules in one core unit
cobas c 501 modules: 1 to 2 modules
cobas e 601 modules: 1 to 2 modules
cobas c 501 | 601 modules: 2 to 3 modules (only 2 units of one module type
for SWA combinations possible)
Sample throughput Up to 120 racks/hr
or samples: 600/hr (theoretical max)
Test throughput 170 up to 2170 tests/hr - overall
(theoretical max) 600 up to 1200 tests/hr - with cobas c 501 modules
170 up to 340 tests/hr - with cobas e 601 modules
770 up to 1370 tests/hr - with photometric and HetIA modules
Number of channels 25 up to 145 channels/reagent slots
(reagent slots) 3 ISE
60 channels (reagent slots, automatic setting) on cobas c 501 module
25 channels (reagent slots) on cobas e 601 module
Programmable parameters 191 parameters with photometric and HetIA modules
117 photometric tests, 3 ISE tests, 8 formulas, 3 serum indices with photometric modules
60 heterogeneous tests with cobas e 601 modules
Sample material Serum, Plasma, Urine, CSF
Core unit analytics Rack: 5 position rack, RD standard rack
Rack types: Routine, STAT, Control, Calibrator, Rerun (manual), Wash
Tray: Tray with 15 racks/75 samples, RD standard tray
STAT port: STAT samples are processed with priority
Sample container types Primary tubes: 5 to 10 ml; 16 x 100, 16 x 75, 13 x 100, 13 x 75 mm
Sample cup: 2.5 ml
Micro cup: 1.5 ml, (exception: cobas e 601 module)
Cups on tube: Cup on top of a 16 x 75/100 mm tube
Cup on top of one non standard tube
False bottom tube: one type is definable
Sample volume 1 - 35 µl
Sample dilution 3 - 121 times, diluent > 100 µl
Sample clot detection Available for cobas c 501 and cobas e 601 module
Minimum sample volume Primary tubes : 700 µl
Sample cup: 100 µl
Micro cup: 50 µl
Sample barcode types Code 128
Codabar (NW 7)
Interleaved 2 of 5
Code 39
cobas® 6000 analyzer series
Common specifications
Control unit PC: Windows XP, Pentium IV processor, DVD-RAM
Monitor: 17’ TFT touch screen colour monitor
Keyboard 101 – key enhanced, country-specific
Printer: optional
PC stand: optional, ergonomic (UL, CE, GS, TüV)
cobas® link data station
System interfaces RS 232 serial interface, bi-directional
Interface to cobas link datastation for cobas teleservice functionalities and automatic download
Sample data base 10.000 routine/STAT samples
Test methods For photometric modules: 1 point, 1 point + prozone check, 2 point, 2 point kinetic, 2 point +
prozone check, 3 point, 1 point + kinetics
Rate A, Rate A + serum index, Rate A with blank, Rate B
Calibrator/QC input Via specified racks through the input buffer or STAT port
Calibration methods Start-up, Re-calibration
For photometric modules: Linear, non-linear multi-points, 2 point calibration, K-factor up
to 100 different calibrators pre programmable
Storage of up to 180 curves
Preventive calibration of the stand-by cobas c and cobas e packs
on cobas c 501: Two k-factor can be defined for different sample types
QC methods For e- and photometric modules: Real-time QC, individual QC, cumulative QC
Up to 100 controls pre programmable
Preventive QC after calibration of the stand-by cassettes/rack packs
Auto QC: QC without operator intervention (timer triggered)
Rerun/reflex function Automatic rerun and manual rerun
Automatic reflex is supported by the system, reflex request to be provided by PSM or LIS
Electrical requirements Power requirements: 230 Volts AC
110 Volts AC
4.5 kVA (for cobas 6000 < 501 | 601 >)
Frequency: 50 Hz or 60 Hz +/- 0.5 %
Water/waste requirements Water: Bacteria free, deionised water supply: resistance of
< 1,0 µS/cm
Water consumption: Under routine conditions in average 15 l / hr , max. 30 l/hr
(per module)
Water pressure: 0.5 – 3.5 kg/cm3, (49 - 343 Kpa)
Biohazards waste: Separate container behind the system
L. concentrated Central drain port, diameter: ≥ 50 mm,
Wall drain < waste: 100 mm above the floor
Regulatory requirements GS, CE, UL, C-UL
Operating conditions Ambient temperature: 15 to 32 °C
Ambient humidity: 45 to 85 % (RH, without condensation)
Heat Output: 1.5 kW (5400 kJ/hr for cobas c 501, 4320 kJ/hr for cobas e 601)
Noise Output: < 68 dB
Physical dimensions Width: 1850 to 4250 mm
Core Unit: 60 cm; per cobas c or cobas e module: 120 cm
Depth: 98 cm; per cobas c or cobas e module
Height: 130 cm
Control unit: Width: 80 cm, depth: 80 cm
Weight 425 to 1000 kg
cobas c 501 module: approx. 350 kg
cobas e 601 module: approx. 380 kg
Core unit: approx. 217 kg
Control unit: approx. 75 kg
cobas® 6000 analyzer series
Elecsys® Test Menu
for cobas e 601 module
Thyroid Function Tumor Markers Infectious Diseases
Anti Tg AFP Anti-HAV
Anti TPO CA 125 II Anti-HAV IgM
Anti TSH receptor CA 15-3 Anti-HBc
FT3 CA 19-9 Anti-HBc IgM
FT4 CA 72-4 Anti-HBe
T3 CEA Anti-HBs
T4 CYFRA 21-1 Anti-HCV
T Uptake free PSA CMV IgG*
Tg hCG+β CMV IgM*
TSH NSE HBeAg
S 100 HBsAg
total PSA HBsAg confirmatory
Fertility / Hormones HIV Antigen
ACTH HIV Antigen confirmatory
C peptide Cardiac HIV combi
Cortisol CK-MB (mass) Rubella IgG
DHEA-S Digoxin Rubella IgM
Estradiol Digitoxin Toxo IgG
FSH Myoglobin Toxo IgM
hCG+β NT-proBNP
Insulin Troponin I*
LH Troponin T Bone Markers
Progesterone β-CrossLaps/serum
Prolactin Vitamin D3 (25-OH)
SHBG Anemia Intact PTH
Testosterone Ferritin N-MID Osteocalcin
Folate P1NP
RBC Folate
Rheumatoid Arthritis Vitamin B12
Anti CCP Maternal Care
AFP
Critical Care free βhCG**
IL6* hCG+β
PCT PAPP-A
S100 PLGF*
SFLT*

Others
IgE

* Assays currently under development.

** only in selected markets
Last Update 06/2008
cobas® 6000 analyzer series
Clinical Chemistry Test Menu
for cobas c 501 module
Substrates Drugs of Abuse Proteins
Albumin Amphetamines α1-Acid Glycoprotein
Ammonia Barbiturates α1-Antitrypsin
Bicarbonate Benzodiazepines α1-Microglobulin
Bilirubin-direct Cannabinoids β2-Microglobulin
Bilirubin-total Cocaine Metabolites Albumin (Immuno.)
Calcium Ethanol Anti-Thrombin
Cholesterol LSD APO A1
HDL Cholesterol Methadone APO B
LDL Cholesterol Methadualone ASLO
sdLDL Cholesterol* Oxycodone* C3c
Creatinine enz. Opiates C4
Creatinine Jaffé Phencyclidine Ceruloplasmin
Fructosamine Propoxyphene CRP
Glucose CRP High Sensitivity
Glucose Hemolysate Cystatin C
Iron Therapeutic Drug Monitoring Ferritin
Lactate Acetaminophen Haptoglobin
Magnesium Amikacin HbA1c (whole blood)
Phosphorus Carbamazepine Homocystein
Total Protein Cyclosporine* IgA
Total Protein U / CSF Digitoxin IgG
Triglycerides Digoxin IgM
UIBC Gentamicin Kappa Light chains
Urea / BUN Lidocaine* Lambda Light chains
Uric Acid Lithium Lipoprotein (a)
MPA-T Myoglobin
NAPA Prealbumin
Enzymes Phenobarbital RF
ACP Phenytoin Soluble Transferrin Receptor
ALP Procainamide Transferrin
ALT / GPT Quinidine
Amylase-tot. Salicylate
Amylase–pancr. Theophylline Electrolytes (ISE)
AST / GOT Tobramycin Chloride
Cholinesterase Valproic Acid Potassium
CK Vancomycin Sodium
CK-MB
GGT
GLDH Others
HBDH D-Dimer
LDH T4
Lipase T-Uptake

* Assays currently under development.

Last Update 06/2008