Chemical stucture

Molecular Atoms Functional Hydrogen bond Chirality Side Rotateable

weight group chain bonds
435.5 g/mol 62 ACE Donor 2 Acceptor 3 10
Inhibitor 6

Physicochemical properties
Log P pKa Melting point solubility
3.2 pKa (Strongest 120-130℃ 1 mg/L
Acidic) : 3.7
pKa (Strongest
Basic) : 5.2

Activity
Pharmacological Side effects Duration of effect Potency Onset of action Half life
effects
ACCUPRIL is Dizziness, lig Peak plasma Quinapril Quinapril is a Eliminati
indicated for the concentrations of oral tablet prodrug and non- on half
htheadednes
treatment quinapril occur can interact sulfhydryl life is 2
s, or
of hypertension, within one hour with other angiotensin hours
tiredness
following oral medications, converting with a
to lower blood may occur as
administration. vitamins, or enzyme (ACE) prolonge
pressure. your body
The extent of herbs you inhibitor with d
Lowering blood adjusts to
absorption is at may be antihypertensive terminal
pressure reduces the medicati least 60%. The taking. An activity. Quinapril phase of
the risk of fatal
on. rate and extent of interaction is is hydrolized into 25 hours
and
Dry cough, n quinapril when a its active
nonfatal cardiov absorption are substance
ausea, form quinaprilat,
ascular events, diminished changes the
or vomiting which binds to
primarily strokes moderately way a drug
may also and inhibits ACE,
and myocardial (approximately works. This
occur thereby blocking
infarctions. 25-30%) can be
the conversion of
when ACCUPRIL t harmful or
angiotensin I
ACCUPRIL is prevent the
ablets are to angiotensin II.
indicated in the drug from
administered
working This abolishes the
management of during a high-fat
well. potent
heart failure as meal.
vasoconstrictive
adjunctive
actions
therapy when
added to of angiotensin
conventional II and leads to
therapy
vasodilatation.
including
Quinapril also
diuretics and/or
causes a decrease
digitalis.
in angiotensin II-
 induced aldoster
one secretion by
the adrenal
cortex, thereby
promoting
diuresis and
natriuresis, and
increases bradyki
nin levels

Route of administration
Oral Parenteral Topical
Tablet - -

Available dosage forms

Tablets Syrup Injection Eye-drop
yes - - -