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Medicinal Chemistry Assignment 3 M. Marks: 50 (2x5 10)

This document contains an assignment for a medicinal chemistry course. The assignment consists of 11 questions covering topics such as the differences between various types of inhibitors, drug screening methods, drug properties, drug targets, and natural products. Students are asked to discuss concepts like prodrugs, enzyme inhibitors, groove binders, drug-target interactions, partition coefficients, and transition state inhibitors, providing examples for each. The assignment is out of 50 marks and focuses on fundamental concepts in medicinal chemistry.

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109 views1 page

Medicinal Chemistry Assignment 3 M. Marks: 50 (2x5 10)

This document contains an assignment for a medicinal chemistry course. The assignment consists of 11 questions covering topics such as the differences between various types of inhibitors, drug screening methods, drug properties, drug targets, and natural products. Students are asked to discuss concepts like prodrugs, enzyme inhibitors, groove binders, drug-target interactions, partition coefficients, and transition state inhibitors, providing examples for each. The assignment is out of 50 marks and focuses on fundamental concepts in medicinal chemistry.

Uploaded by

NIKITA
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
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Medicinal Chemistry

Assignment 3
M. Marks: 50
Q1. Distinguish between (2x5=10)
i. Suicide inhibitor and reversible inhibitor
ii. In vitro and In vivo screening
iii. Antagonist and inverse agonist
iv. LD50 and ED50

v. Surface receptor and intracellular receptor

Q2. Discuss Lipinski Rule of 5 with suitable example. 4


Q3. Discuss the mechanism of action of amsacrine and mechlorethamine. 4
Q4. What do you understand by the term prodrug? Discuss how they can be useful in improving
drug activity and drug stability using specific example. 4
Q5. Discuss the target specificity and selectivity between species using suitable example 4
Q6. Discuss medicinal uses of enzyme inhibitors using any two examples 4
Q7. Discuss the different properties of groove binders with suitable example. Why they prefer AT
rich region only? 4

Q8. Discuss drug target interaction explaining the role of hydrophobic interactions and hydrogen
bonding involved in the binding of drug in the active site of the receptor. 4
Q9. Define the partition coefficient and why the value of Log P is important in drug design4
Q10. What are the advantages and disadvantages of natural products as lead compounds? 4
Q11. Discuss the transition state inhibitor with suitable example. 4

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