Crono

AMBULATORY INFUSION PUMP

USER GUIDE
Crono
USER GUIDE
TABLE OF CONTENTS

SECTION 1
Foreword . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . page 7
Note . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . page 7
Intended use . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . page 7
User assistance information . . . . . . . . . . . . . . . . . . . . . . . . . . . . page 7

SECTION 2
Pump description. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . page 8
Factory settings . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . page 8
Technical features . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . page 9

SECTION 3
Standard equipment supplied . . . . . . . . . . . . . . . . . . . . . . . . . . page 10
Optional accessories . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . page 11

SECTION 4
How to use standard equipment supplied . . . . . . . . . . . . . . . . . page 12
How to wear the pump . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . page 13

SECTION 5
Pump parts . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . page 14
Liquid Crystal Display . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . page 15
Main screen indications. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . page 16

SECTION 6
Syringe parts . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . page 17
Luer Lock Cap functions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . page 17
Infusion set . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . page 18
Infusion set parts . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . page 18
Infusion sites . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . page 19
Infusion preparation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . page 19
Syringe preparation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . page 20
Connection of the syringe to the pump . . . . . . . . . . . . . . . . . . . . page 21

SECTION 7
Working instructions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . page 22
Pump activation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . page 23

SECTION 8
Programming . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . page 25

5 MAN 01/C/05
 TABLE OF CONTENTS

SECTION 9
Switching on the device . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . page 27
Priming the infusion set. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . page 27
End of infusion. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . page 28
Storing data . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . page 28
Switch off . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . page 28
Reading the number of infusions . . . . . . . . . . . . . . . . . . . . . . page 28
Re-setting the number of infusion . . . . . . . . . . . . . . . . . . . . . . . . page 29
Reversal of pump piston . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . page 30
Piston movements. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . page 30
Infusion set occlusion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . page 30
Tamper resistant feature . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . page 31

SECTION 10
Low battery alert . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . page 33
Battery replacement . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . page 33

SECTION 11
Cautions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . page 35
Maintenance and cleaning . . . . . . . . . . . . . . . . . . . . . . . . . . . . . page 36
Storage . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . page 36

SECTION 12
User Assistance information . . . . . . . . . . . . . . . . . . . . . . . . . . . . page 37
Manufacturer’s guarantee . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . page 37

SECTION 13
Alarm messages . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . page 39
Summary of functions and buttons . . . . . . . . . . . . . . . . . . . . . . . page 40

SECTION 14
Pump icon table. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . page 41
Syringe blister icon table . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . page 42

SECTION 15
A glossary of terms . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . page 44

SECTION 16
Index of illustrations. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . page 46

MAN 01/C/05
6
SECTION 1

FOREWORD
CAUTION: US Federal law restricts this device for sale by or on order of
a physician.
This manual is written with the aim of informing the user of this pump. The
instructions and details given here are fundamental for the correct and
safe use of this device.
Please take time to read all the information before using the pump and
moreover keep this guide in a safe place for future reference.

NOTE
The manufacturer only considers itself responsible for the safety and relia-
ble working of this pump, provided that it is used in accordance with the
current instructions for use.
The manufacturer declines all responsibility towards the purchaser and
any third party for any damage to the pump caused by tampering, impro-
per use, modifications and/or reparations by unauthorised personnel.

INTENDED USE
The ambulatory infusion pump Crono has been designed for subcuta-
neous drug infusions. Canè S.r.l. declines all responsibility for the admini-
stration of drugs and solutions and/or methods of drug infusions other than
those described in this manual.

USER ASSISTANCE INFORMATION

UNITED STATES:
INTRA PUMP INFUSION SYSTEMS
920 Minters Chapel Road, Suite 200
Grapevine, Texas 76051
Tel: 866-211-7867
Fax: 630-845-2768
Email: info@intrapump.com

7 MAN 01/C/05
 SECTION 2

PUMP DESCRIPTION
Canè S.r.l. - a company specialized in the production of ambulatory
pumps since 1972 - has developed a new generation of compact pumps:
Crono which is a perfect combination of high technology and innovative
design.

Infusion pumps using normal commercial syringes are bulky and cumber-
some and thus difficult to use in the true sense of "ambulatory". This can
have a negative impact on patient compliance and treatment goals.

A special syringe, an integral part of Crono, provides an efficient reduction

of overall pump size. Whether day or night infusion is required, Crono
offers more conveniences and advantages than other bulkier, heavier
pumps.

Patients who have been following subcutaneous infusion therapy for a

long time often experience difficulties in absorbing the drug subcuta-
neously. This may lead to catheter occlusion with infusion interruption.

Crono has a unique mechanism which responds to occlusion and provi-

des an infusion thrust up to three times higher than conventional pumps.
Normal infusion is resumed when catheter occlusion has been eliminated.

In order to provide steady infusion and continuous drug absorption, Crono

infuses the fluid volume to be administered in pulses of .022 ml. These
pulses are spread evenly over the time set for completing the infusion.

FACTORY SETTINGS
The following features were set at the factory but can be re-programmed:

Syringe size 20 ml
Audible signal for end infusion AL.0 (Non active)
Delivery time 10 hours
Key-pad lock level Lo,0 (key-pad unlocked)
Number of infusions 0

MAN 01/C/05
8
 TECHNICAL FEATURES

Dimensions 77x48x29 mm (3x1.9x1.1 inch).

Weight 115 g (battery included).

Battery 3 Volt type 123 A lithium battery.

Syringes Dedicated with 10 or 20 ml capacity.

Volume administration Drug volume can be programmed

from 1 to 20 ml.

Delivery time Programmable from 30 minutes to

99 hours, in 15 minutes steps.

Accuracy +/- 2%.

Available occlusion pressure 4,5 bar +/-1.

Data storage Programmable data are automati-

cally stored in the pump’s memory;
the data are not lost when the bat-
tery is removed.

Safety circuits To control the regular working of the

device, alarming in the event of ano-
maly and displaying error message.

Tamper resistant feature Allows the pump to be “locked” by

disambling the buttons.

Operating conditions +10°C / +45 °C

30% / 75% RH
700 hPa / 1060 hPa

Storage conditions -10°C / +60 °C

10% / 100% RH
500 hPa / 1060 hPa

9 MAN 01/C/05
 SECTION 3

STANDARD EQUIPMENT SUPPLIED

1. Ambulatory infusion pump
2. Pump case
3. Elastic belt
4. Collar strap
5. Fabric holder
6. 2 batteries (one already inserted in the pump)
7. Battery tool
8. User guide
Fig.1

6 4

5
7

MAN 01/C/05
10
 OPTIONAL ACCESSORIES

Optional accessories are available upon request:

1. Upright leather holder similar to a mobile telephone holder.
2. Horizontal leather holder similar to a spectacle case.

Fig.2

11 MAN 01/C/05
 SECTION 4

HOW TO USE THE STANDARD EQUIPMENT SUPPLIED

The following illustrations show how the pump and its accessories can be
set up.

Fig.3
How to attach collar strap to the
pump and the fabric holder
10

20 ml

Fig.4
How to use elastic belt with
pump and fabric holder

MAN 01/C/05
12
 HOW TO WEAR THE PUMP

The following pictures show the different ways the pump can be worn.

WEARING THE PUMP AROUND THE NECK

Fig.5

Wearing the pump around the neck with collar

strap and fabric holder

Fig.6 WEARING THE PUMP AT THE WAIST

Wearing the pump at the waist with elastic belt

and fabric holder

13 MAN 01/C/05
 SECTION 5

PUMP PARTS
Fig.7 Syringe fin hook

Display
Collar strap
locking rings

Button + Button
- Button
d

Pump piston Battery

compartment

Serial number

Brief
instructions

MAN 01/C/05
14
 LIQUID CRYSTAL DISPLAY
This is a screen on the front of the pump displaying symbols which inform
the patient of operations in progress as well as showing warnings and
alarm messages.

10

20

10
“Battery” symbol: appears when the battery is nearly expired (see
20 the related paragraph, page 30)

“Drip” symbol: flashes when the device is on; it alternates with

indication of hours and minutes

10 “10 ml” symbol: indicates the device has been programmed to

use 10 ml (CRN 10) syringe

20 “20 ml” symbol: indicates the device has been programmed to use
20 ml (CRN 20) syringe

15 MAN 01/C/05
 SECTION 6

MAIN SCREEN INDICATIONS

DELIVERY TIME
10

20

10

20
PARTIAL VOLUME

10

20
OFF INDICATION

20 ML SYRINGE SELECTED
10

20

END OF INFUSION AUDIBLE SIGNAL (ON)

10

20

ERROR MESSAGE
10

20

OCCLUSION
10

20

BACKWARDS/FORWARDS MOVEMENTS OF THE PUMP PISTON

10

20

END OF INFUSION
10

20

LOW BATTERY
10

20

BATTERY DISCHARGED
10

20

DISPLAYING THE NUMBER OF INFUSIONS

10

20

KEY-PAD UNLOCKED
10

20

10

20
KEY-PAD LOCKED: LEVEL 1

10

20
KEY-PAD LOCK SETTING

MAN 01/C/05
16
 SYRINGE PARTS
The Crono pump uses dedicated syringes which are available in two sizes:
• CRN® 10 ml CRONO® Syringe
• CRN® 20 ml CRONO® Syringe

The syringes are:

• Single use only
• To be used only if packaging is not damaged
• Pyrogen-free

Fig.8

Syringe structure
20ml

Needle
10

Plunger
Needle’s cap
Plunger Rod

Luer-lock cap

LUER LOCK CAP FUNCTIONS

• Can be used after the syringe has been filled, in
order to unscrew the plunger rod from the plunger
Fig.9

with ease.
• To protect the drug in the syringe if infusion is not
imminent.
Luer-Lock cap

17 MAN 01/C/05
 INFUSION SET
It is advisable to use infusion sets which have the following specification:
• Tube with internal diameter of limited dimensions (optimum 0.36 mm,
maximum 0.6 mm);
• Length of the tube not exceeding 90 cm;
• Tube with dead space lower than 0.5 ml;
• Anti-kink tube.

INFUSION SET PARTS

Fig.10

Female
Needle
Luer lock

Tube

MAN 01/C/05
18
 INFUSION SITES
Fig.11
Infusion sites can be any of the following:

• Anterior aspects of upper arm

• Anterior abdominal wall
• Anterior aspect of thighs

It is advisable to change infusion site after each

drug administration in order to avoid skin irrita-
tion.

INFUSION PREPARATION

Before preparing the equipment for infu-

sion, it is advisable to follow these pre-
cautions:

1 - Wash your hands

2 - Prepare a clean working area
cr n

min
h

OFF
d
O
CRON
OJET
ml MICR
0.2

19 MAN 01/C/05
 SYRINGE PREPARATION
1.Put the supplied needle on the syringe with a clockwise rotation.

2.Fill up the syringe, aspirating the drug slowly to avoid disconnection be-
tween the rubber plunger and plunger rod. Verify the drug inside does
not exeed 10 or 20 ml capacity.

3.Unscrew the plunger with a brisk counter-clockwiser rotation.

4.Put the subcutaneous tubing on the syringe with a clockwise rotation.

5.Insert the syringe into the instrument with a 90° rotation, making sure to
detect a “click” which indicates the syringes is locked into the pump.

MAN 01/C/05
20
 SYRINGE PREPARATION
Fig.12
1 2 3 4 5

10

20 ml
10
10

20 ml
20 ml

10

10
20 ml

20 ml

CONNECTION OF THE SYRINGE TO THE PUMP

Fig.13

min
h
min

OFF
h

d
O OFF
R ON d
TC
JE O
RO R ON
0.2
ml
MIC TC
JE
RO
0.2
ml
MIC

Top view

21 MAN 01/C/05
 SECTION 7

WORKING INSTRUCTIONS
• Press the buttons with your finger-tips only, do not use sharp or poin-
ted objects.

min min
h h

OFF
OFF

Fig.14
d O d
ON
CR NO
T
OJE
RO
R TC
l MIC JE
0.2
m
RO
ml MIC
0.2

• Time-controlled buttons: keep buttons pressed for a few seconds to

activate commands.

• Button activation is confirmed by a ticking sound, except in the phase

of battery insertion.

• Command execution is confirmed by a brief audible signal.

• Before starting the infusion, check that the 10 ml or 20 ml syringe setting

has been selected correctly.

• The pump is supplied with a battery already inserted.

MAN 01/C/05
22
 PUMP ACTIVATION
During the device activation phase it is possible to select the fol-
lowing parameters:
• Syringe size (10 ml or 20 ml)
• End of infusion audible signal (ON or OFF)

The syringe size and the end of infusion signal can only be
selected and/or changed immediately after battery insertion.
Device activation:

1. Remove, and then re-insert the battery

2. The pump will carry out a self-test, during which the display 10

will show all readable symbols and emit audible signals

20

3. While syringe size symbol is flashing (the numbers “10“or 10

“20”), you may select syringe sizes.

20

Use the or buttons to make your selection.

If, for example, the number “10” is flashing, press the but-
ton and keep it pressed for a few seconds until the number
“20” appears.

10 ml syringe 20 ml syringe
10 10

20 20

+
-
10 10

20 20

10 10

20 20

The information regarding the syringe size will always be shown

on the display.

4. After syringe size selection, you may activate/deactivate 10

an audible signal for end of infusion. While the display blinks,

20

you may select to either have the audible signal or not by

pressing the or buttons .
23 MAN 01/C/05
 Audible signal ON
10

20

Audible signal OFF

10

20

5. After a few seconds, the pump automatically returns the

pump piston to its starting position, then the screen
displays OFF.
10

20

The selected data are automatically stored in memory.

Fig.15

20 20 ml
20 ml
10

20 ml syringe

10 10 ml
10ml
5

10 ml syringe

MAN 01/C/05
24
SECTION 8

PROGRAMMING
• Delivery time
• Partial volume

PROGRAMMING THE DELIVERY TIME

Delivery time can be programmed at the following rate:
• 10 ml syringe: from 30 min to 99 hours, with 15 minutes steps
• 20 ml syringe: from 1 to 99 hours, with 15 minutes steps

Program the delivery time proceeding as follows:

1. Switch on the pump by briefly pressing the button.

2.The adjustment of delivery time (hours and minutes) either 10

up or down from what is shown on the screen is accomplished

20

by first pressing until the current delivery time starts to

flash. If you wish to increase the delivery time, you 10

continue to press until the desired time shows on

20

the screen.If you wish to decrease the delivery time,

press until the desired delivery time appears on the
screen.
Continuous button pressure causes a rapid change of
the delivery time. When buttons are not pushed for a five
second period, the time is set and the display stops
flashing.

3. To store the delivery time press the and buttons

simultaneously, the device issues a sound signal and the
indication on the screen disappears for a short while; this
to confirm that data have been successfully stored.

25 MAN 01/C/05
 PROGRAMMING PARTIAL SYRINGE VOLUME
If the therapy requires the use of a partially filled syringe, the
infusion starting point of the pump piston can be stored into
the pump’s memory.
Proceed as follows:

1. Press the button: the pump piston will advance up to

the position corresponding to the volume of drug to be
10

20

infused.

2. Switch off the pump by pressing the and buttons.

The screen will display OFF.
10

20

3. Press the and buttons simultaneously. The device

will issue an audible signal and the screen will display the
10

20

stored volume

4. At the end of the infusion the pump piston will return to the
stored position.
10

20

5. The stored position can be changed by repeating the pro-

cedure above.

6. Any time the pump is switched on, the screen will display
the cc stored volume.
10

20

7. Such setting will be maintained until the battery is remo-

ved.

MAN 01/C/05
26
SECTION 9

SWITCHING ON THE DEVICE

By pressing button, the screen will swiftly display the follo-

wing order of sequence:

• Stored syringe volume given in cc (appears only if formerly

stored)
10

20

• The instrument will emit a brief sound and show the delivery 10

time (hours and minutes), with the blinking “drip” symbol

20

separating hours from minutes.

The infusion time on the display decreases every 15 minutes.

PRIMING THE INFUSION SET

Before beginning the infusion, you must check whether the
pump piston is in contact with the plunger. If this is not the
10

20

case, move the piston forward by pressing button .

Any time you press this button the pump piston moves forward
with increments of 0.45 mm corresponding to 0.2 ml.

Continue this process until a few drops of the fluid to be infu-

sed come out of the needle.

WARNING
Make sure the infusion set is not connected to the patient
during priming!

27 MAN 01/C/05
 END OF INFUSION

If the acoustic signal is activated 10 minutes prior to the end of

infusion, the device will emit a two second lasting intermittent
signal.
The same signal will be repeated twice 5 minutes before the
infusion ends.
At the end of infusion a continuous acoustic alert lasting a few
seconds will be emitted. The screen will display the message
10

20

END.
The pump piston will automatically return to its starting posi- 10

tion. The screen will read OFF.

20

The pump piston reversal time is about:

• 5 minutes for 10 ml syringes
• 10 minutes for 20 ml syringes

STORING DATA
Information regarding syringe size, delivery time and number of infusions
already administered will be automatically stored in the memory. Stored
data are not lost even when battery is removed.

SWITCH OFF

Press the and buttons simultaneously to switch off the 10

pump during the infusion. The display will show OFF.

20

READING THE NUMBER OF INFUSIONS

Keep the button pressed for 8 seconds in OFF condition:

the display will show the number of infusions already admini-
10

20

stered.

MAN 01/C/05
28
 RE-SETTING THE NUMBER OF INFUSIONS
As each infusion is finished a record of this is automatically
kept by the pump, even if the battery is removed.
Instructions on how to retrieve this information is on page 28.

However, there are some situations in which it is helpful to be

able to re-set the number of infusions back to the factory
setting of 0000 infusions.

1. With the pump switched OFF, press the button until the
10

number of infusions appear on the screen.

20

2. Without releasing the button, press the button.

3. The number of infusions will flash on the screen.

10

20

4. Release the button.

5. In sequence press the button , the button and

finally the button for about 2 seconds each. (If the audio
alarm is activated, there will be a “ticking” sound during each
of these 2 second periods. When this sound stops, the
button can be released).

6.The screen will show 0000 infusions if the procedure is done

10

correctly.
20

The screen will show UNDO if the procedure is done 10

incorrectly

29 MAN 01/C/05
 REVERSAL OF PUMP PISTON
1. Total reversal
It is possible to interrupt the infusion already in progress and
make the pump piston return to its starting position. Proceed in
the following way:

a. Switch off the pump by pressing the and buttons

10

simultaneously.
20

b. Press the and buttons, simultaneously. The display

10

will show END.

20

c. The pump piston will return to its starting position.

10

20

2. Automatic reversal of pump piston at the END of infusion

When infusion ends you will read END on the display.
10

20

The pump piston will automatically return to its starting position,

10

and the display will show OFF.

20

PISTON MOVEMENTS
When the pump piston has to move either backwards or for-
wards you will read a symbol on the display indicating this.
10

20

INFUSION SET OCCLUSION

When the infusion set occludes, Crono indicates the status of
occlusion by emitting an audible acoustic alarm and a message
10

20

on the display. Every two minutes the device attempts to advan-

ce the pump piston. When the occlusion is cleared and the

MAN 01/C/05
30
pump resumes regular delivery, the screen will alternate the occlusion
warning message with the information regarding the delivery time.

TAMPER RESISTANT FEATURE

The tamper resistant feature allows the pump to be “locked” by
disabling the buttons.
Putting the pump in the tamper resistant mode does not alter
or impede any of the normal functions or alarms of the pump.It
is designed to reduce the risk of inappropiate button pressing.
IT IS RECOMMENDED THAT SMALL CHILDREN BE
INSTRUCTED TO NOT TOUCH BUTTONS REGARDLESS
OF WHETHER THIS FEATURE IS ACTIVATED OR NOT.

First of all, “Lo,0” message on the screen means that the pump
is in normal, unlocked mode. “Lo,1” means that the pump is
locked.

TO LOCK THE PUMP:

1. Turn the pump on and set the delivery time.

2. When you are satisfied that the pump is working properly,

3. Press the button for about 7 seconds.

10

4. Will appear on the screen.

20

10

20

5. Without releasing the button, press the button.

6. “Lo,0” will appear on the screen.

10

20

7. Press button and “Lo,1” will appear. 10

20

8. If you wish to leave the pump locked, simply stop pushing

buttons.

31 MAN 01/C/05
 9. The pump will resume operation in lock mode.

10. THE SYRINGE SIZE NUMBER WILL NOW FLASH ON

THE SCREEN ,TO REMIND YOU THAT THE PUMP IS
LOCKED

TO UN-LOCK THE PUMP

This procedure is similar to locking the pump.

1. Press the button for about 7 seconds.

10

2. Will appear on the screen.

20

10

20

3. Without releasing the button, press the button.

4. “Lo,1” will appear on the screen.

10

20

5. Press button and “Lo,0” will appear.

10

20

6. The syringe size will now show a normal steady number.

MAN 01/C/05
32
SECTION 10

LOW BATTERY ALERT

The LOW BATTERY warning will appear on the screen to indi-

cate that battery level is low. It is time to change the battery as
10

20

soon as possible.
If the battery is not replaced soon after the screen warning, a
subsequent infusion could be interrupted.

If the battery is allowed to fail completely, the screen will show

the message “BATTERY DISCHARGED”. In such a situation
10

20

the pump has stopped. The battery must be replaced imme-

diately .

It is advisable to change the battery as soon as the “LOW BAT-

10

TERY” symbol appears.

20

BATTERY REPLACEMENT

1. Open the battery compartment using the battery tool or a paper clip.
2. Pull out the cover.
3. Use the small ribbon strap (which lies under the battery) to facilitate the
removal of the battery.
4. Remove the discharged battery and discard it properly.
5. Insert the new battery checking that it is correctly placed in accordance
with polarity and that the ribbon strap is under the battery.
6. After having installed the battery, close the cover.

If the battery cannot be removed by pulling the strap, do not try to lever
with an object or tool. Take the pump firmly in one hand and, as gently as
possible, shake the battery out onto your other hand.

33 MAN 01/C/05
 BATTERY REPLACEMENT

Fig.16

PID
PID
CRONO
CRONO

CR
CROONNO
O PI
PIDD

1 2

3 4

5 6

MAN 01/C/05
34
SECTION 11

CAUTIONS
• Use only a lithium 3 Volt CR 123 A battery.

• Batteries other than this type may cause the pump to malfunction.

• Batteries of the above-mentioned type are readily available in camera

stores and most pharmacies.

• Under average operating conditions, each battery should last about 150
infusions. Keep a spare battery in a convenient place.

• If the pump is not used for long periods of time, it highly recommended
to remove the battery from the pump.

• Remove the pump before taking a bath or shower: the pump may be
damaged upon contact with water. Should the pump accidentally come
into contact with any liquid (drug solution, sweat, bed wetting) the
pump must be checked by the manufacturer or a qualified personnel
authorised by the manufacturer.

• If you suspect that liquid has penetrated into the pump (a leakage or
spill), please contact the appropriate person within your specialist health
care team or your authorized distributor for advice.

• The pump must be kept away from:

- heating devices (radiators, oven rings, stoves);
- direct sunlight;
- high electromagnetic fields (magnets, loud-speakers, portable radio
devices, cell phones);
- ionogenic radiations;
- supersonant devices
- magnetic resonance devices (MRI)

• The pump does not need to be sterilized.

• Syringes, infusion set, needles, and all material used during the infusion
process must be discarded properly.

35 MAN 01/C/05
 MAINTENANCE AND CLEANING
The Crono pump requires no particular maintenance operation, owing to
its technical features.

To clean the instrument, use a soft cloth slightly moistened with a mild
detergent.

Avoid the risk of liquid penetration into the instrument.

In the event the instrument becomes wet, absorb the liquid with blotting-
paper.

STORAGE
If the pump is not going to be used for a long period of time (more than 1
or 2 months), it is advisable to remove the battery, put it inside the device
case and store it in a dry place.

MAN 01/C/05
36
SECTION 12

USER ASSISTANCE INFORMATION

UNITED STATES:
INTRA PUMP INFUSION SYSTEMS
920 Minters Chapel Road, Suite 200
Grapevine, Texas 76051
Tel: 866-211-7867
Fax: 630-845-2768
Email: info@intrapump.com

MANUFACTURER’S GUARANTEE

With this consumer guarantee, Canè S.r.l. guarantees that this product
is free from defects in materials and workmanship for a period of 2
(TWO) YEARS beginning from the date of purchase.

If during this period of guarantee the product proves defective due to

improper materials or workmanship, Canè S.r.l. will without charge for
labour or parts, repair or replace the defective parts upon the terms and
conditions set out below.

Canè S.r.l. reserves the right to modify the characteristics or the model
of the pump and accessories without obligation to make similar modifi-
cations to pumps and accessories previously manufactured or sold.

Conditions:
1. This guarantee will be granted only if the defect is brought to the
attention of Canè S.r.l.

2. This guarantee will not be in effect if the pump and accessories have

37 MAN 01/C/05
been damaged as a result of modifications or adjustments made
without prior written consent from Canè S.r.l.

3. This guarantee will not apply if the type or serial number on the product
has been altered, deleted, removed or made illegible.

4. This guarantee does not cover any of the following:

• Periodic maintenance
• Damage resulting from misuse, including but not limited to:
- Failure to use the product for its normal purpose or in accordan
ce with this user’s guide;
- Repair done by non-authorized Service Stations or Dealers, or
the customer himself;
- Accidental events, dropping, liquid infiltration.
• Natural calamity, fraudulent or premeditated action

5. Once the warranty period has expired, Canè S.r.l. will provide the
service debiting the costs of components being replaced, expenses of
labour charges and freight charges.

MAN 01/C/05
38
SECTION 13

ALARM MESSAGE
ALARM MESSAGE DESCRIPTION ACTION

OPERATION NOT POSSIBLE RE-CHECK MANUAL

10

20

UNCORRECTED RESET RE-START DEVICE

10

+
20

10 CRITICAL CONDITION OF THE

PRESS BUTTON
SECURITY SYSTEM

+
20

10 IRREGULARITY OF THE PRESS BUTTON

20 MOTOR CIRCUIT

MECHANICAL BLOCK DURING “END” 1. REMOVE THE CAUSE

2. RE-START DEVICE
10
PHASE CAUSED BY FOREIGN MATTER
OBSTRUCTING THE PISTON’S REVERSAL

+
20

IRREGULARITY OF THE PUMP PRESS

10
BUTTON
PISTON’S ADVANCEMENT
20

OCCLUSION
PRESS
+
10

20
BUTTON

READING MEMORY ERROR

RE-START DEVICE*
10

20 (EEPROM)

ERROR WITHIN THE MOTOR

RE-START DEVICE
10

20 PILOTING CIRCUIT

Alarm messages are accompanied by audible signals.

To re-start the device following an alarm message, remove the battery
and wait least 15 seconds before re-inserting.

Please note: if your pump shows Err8, and you subsequently re-start
*

it, the programmed settings will revert to the factory settings (see
page 8). Therefore, whenever this condition takes place, you must re-
program the settings assigned by your doctor or PD nurse.

If the device will not re-start, contact your authorized distributor.

39 MAN 01/C/05
 SUMMARY OF FUNCTIONS AND BUTTONS
The follow brief instructions are by no means an alternative to reading the information supplied in this
manual. The following tables are both a concise and quick reference with regard to pump use and its
buttons.
Time control buttons: the buttons must be pressed for a few seconds if a command is to be carried
out. This ensures that if the patient accidentally touches a button, no commands will be activiated.
BUTTONS PUMP ACTIVATION / SYRINGE SIZES AND END INFUSION SIGNAL SCREEN
The syringe sizes and the end infusion signal can only be selec-
ted and/or changed immediately following the battery insertion.

• The screen will show all symbols

IINSERTING BATTERY PHASE

10

20

- +
• Syringes Size setting (10 / 20 ml)
/
10 10

20 20

• Setting the acoustic signal of end infusion

10 10

20 20

• Piston self-adjust
10

20

• Pump switches OFF 10

20

BUTTONS PUMP SWITCH OFF / STORING OF PARTIAL SYRINGE VOLUME SCREEN

d and - • Reversing of the pump piston to the start position

10

20
10

20
10

20

depress simultaneously

d and + • Storing of the partial syringe volume 10

PUMP OFF

-
depress simultaneously
20

• Reading of no. of infusions delivered 10

depressed for 8 seconds

20

PUMP ON

+ • Pump switches ON

BUTTONS PROGRAMMING THE DELIVERY TIME / PRIME SCREEN

- / + • Decreasing or increasing of the delivery time

10

20

d and + • Delivery time storing

depress simultaneously

d • Prime (0.2 ml)

10
PUMP ON

20

d and - • Pump piston return (partial)

10

20

depress simultaneously

PUMP OFF

- and + • Pump switches OFF

10

20

depress simultaneously

END OF INFUSION SCREEN

• End of infusion
10
END OF INFUSION

20

• Piston automatic reversing

10

20

• Automatic switch OFF

10

20

MAN 01/C/05
40
SECTION 14

PUMP ICON TABLE

SN Pump serial number

Drip-proof instrument
It can withstand occasional liquid dripping or splashing.
It must not be immersed in liquid.
Electromedical equipment
BF type

Warning: see instructions for use

Dispose of used electric and electronic devi-

ces in an environmentally safe manner, using
the appropriate containers and according to
any regulations that may apply.

41 MAN 01/C/05
 SYRINGE BLISTER PACKAGE ICON TABLE

i Read the instructions

0123 CE mark

Recycle

2 Do not re-use this device

PYROGEN Pyrogen free

Protection against moisture

Do not expose to direct sunlight

Expiration date

STERILE EO Sterilized by Ethylene oxide

PP Polypropylene

LOT Lot number

REF
Ref number

NEEDLE
Needle dimensions

MAN 01/C/05
42
 SECTION 15

A GLOSSARY OF TERMS

Alarm
An alarm is a condition that warrants the user’s attention, and is critical
enough that it requires that the pump be shut down or reset.
When an alarm occurs, an alarm beep is sounded and a descriptive mes-
sage appears on the display screen.

Display screen
The pump’s liquid crystal display screen is located on the front panel of the
pump, providing the information about the functioning of the pump.

Infusion pump for ambulatory use

Pump intended to be carried continuously by the patient.

Infusion set
An infusion set consists of a length of thin plastic tubing with a luer lock
connector at one end. At the other end, there is a very small needle that is
placed under the skin. The infusion set is connected to the pump and used
to deliver drugs, in fluid form, to the body.

Infusion site
The infusion site is the place on the body where the infusion set needle is
inserted under the skin.

Luer-lock connector
A luer-lock connector is a special threaded fitting used to connect the infu-
sion set to the syringe.

Occlusion
Occlusion means “blockage”. The pump is designed to be able to sense
when delivery of the drug is being blocked for some reason. The pump will
automatically stop delivering drug and sound an alarm to alert you to clear
the occlusion and restart the pump.

43 MAN 01/C/05
 Subcutaneous
Subcutaneous means beneath the skin. The infusion set needle is pla-
ced subcutaneously.

Syringe pump
Pump intended for controlled infusion of liquids into the patient by a
syringe, and in which the delivery time is set by the operator.

MAN 01/C/05
44
SECTION 16

INDEX OF ILLUSTRATIONS

Figure 1 Standard equipment supplied

Figure 2 Optional accessories
Figure 3 How to attach collar strap to the pump and the fabric holder
Figure 4 How to use elastic belt with pump and the fabric holder
Figure 5 Wearing the pump around the neck
Figure 6 Wearing the pump at the waist
Figure 7 Pump parts
Figure 8 Syringe parts
Figure 9 Luer lock cap
Figure 10 Infusion set parts
Figure 11 Infusion sites
Figure 12 Syringe preparation
Figure 13 Connection of the syringe to the pump
Figure 14 Working instructions
Figure 15 Selecting the syringe size
Figure 16 Battery replacement

45 MAN 01/C/05