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Teratoma: Neuroepithelial Rosettes and Tubules, Cellular Foci of

This document summarizes different types of teratomas found in the ovaries. It describes immature teratomas as containing predominantly neuroectodermal elements like neuroepithelial rosettes and tubules. Mature teratomas, also called dermoid cysts, contain fully differentiated tissues from all three germ layers sometimes arranged in organoid structures, and can elicit an inflammatory response if cyst contents escape. Carcinoid teratomas resemble gastrointestinal neuroendocrine tumors and can display patterns like insular, trabecular or strumal, with the latter resembling the follicular cells of the thyroid.

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Salon Lamichhane
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35 views2 pages

Teratoma: Neuroepithelial Rosettes and Tubules, Cellular Foci of

This document summarizes different types of teratomas found in the ovaries. It describes immature teratomas as containing predominantly neuroectodermal elements like neuroepithelial rosettes and tubules. Mature teratomas, also called dermoid cysts, contain fully differentiated tissues from all three germ layers sometimes arranged in organoid structures, and can elicit an inflammatory response if cyst contents escape. Carcinoid teratomas resemble gastrointestinal neuroendocrine tumors and can display patterns like insular, trabecular or strumal, with the latter resembling the follicular cells of the thyroid.

Uploaded by

Salon Lamichhane
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Teratoma

- Immature
- Mature; solid, cystic (dermoid cyst)
- Monodermal (e.g. struma ovarii, carcinoid)

Immature teratoma

- Varies from small foci to a predominant component and is


composed primarily of neuroectodermal elements;
neuroepithelial rosettes and tubules, cellular foci of
mitotically active glia, and, occasionally small areas
resembling glioblastoma multiforme or neuroblastoma.
- Mature components of varying amounts may also be seen.

Dermoid Cyst

- Adult-type tissues, usually representing all 3 germ layers,


sometimes arranged in an organoid fashion. Small foci of
fetal-type tissues may occur.
- Ectodermal(predominate)>mesodermal>endodermal
- Neuroectodermal elements can incite a florid vascular
proliferation.
- Escaped cyst contents elicit a characteristic
lipogranulomatous response in the wall of the cyst or the
surrounding.

Carcinoid teratoma
 Resembles carcinoid tumors elsewhere; nuclear features of
neuroendocrine tumor such as salt and pepper chromatin may be
helpful but are also seen in follicular cells of strumal carcinoid
 Patterns are insular (resembles appendix or small bowel tumors),
trabecular (resembles stomach or rectal tumors), strumal (below),
mucinous
o All have a gastrointestinal counterpart except strumal
carcinoid
o Mixed primary ovarian carcinoids, such as insular and
trabecular or strumal and goblet cell do exist
 May have abundant fibrous stroma rich vessels
 Rarely has prominent pleomorphism, mucinous features or signet
ring pattern

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