Scribd
Upload
183 views35 pages

Fentanyl Synthesis for Chemists

This document describes an efficient synthesis of fentanyl and related analogs. It provides NMR data including 1H NMR and 13C NMR spectra to support the synthesis of fentanyl, acetylfentanyl, thiofentanyl, and acetylthiofentanyl, as well as their hydrochloride and citrate salts. The document includes NMR data on intermediates in the synthesis of these compounds.

Uploaded by

marcel bok
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
183 views35 pages

Fentanyl Synthesis for Chemists

This document describes an efficient synthesis of fentanyl and related analogs. It provides NMR data including 1H NMR and 13C NMR spectra to support the synthesis of fentanyl, acetylfentanyl, thiofentanyl, and acetylthiofentanyl, as well as their hydrochloride and citrate salts. The document includes NMR data on intermediates in the synthesis of these compounds.

Uploaded by

marcel bok
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
You are on page 1/ 35

An efficient, optimized synthesis of fentanyl and related analogs

Carlos A. Valdez, Roald N. Leif and Brian P. Mayer*

Forensic Science Center, Lawrence Livermore National Laboratory


Livermore, CA 94550 USA

- Supporting Information -

Content Page
1
H NMR of N-phenylethylpiperidin-4-one (13) S2
13
C NMR of N-phenylethylpiperidin-4-one (13) S3
1
H NMR of N-[1-(2-phenylethyl)-4-piperidinyl]aniline (14) S4
13
C NMR of N-[1-(2-phenylethyl)-4-piperidinyl]aniline (14) S5
1
H NMR of Fentanyl (4) S6
13
C NMR of Fentanyl (4) S7
1
H NMR of Fentanyl hydrochloride (15) S8
13
C NMR of Fentanyl hydrochloride (15) S9
1
H NMR of Fentanyl citrate (16) S10
13
C NMR of Fentanyl citrate (16) S11
1
H NMR of Acetylfentanyl (9) S12
13
C NMR of Acetylfentanyl (9) S13
1
H NMR of Acetylfentanyl hydrochloride (17) S14
13
C NMR of Acetylfentanyl hydrochloride (17) S15
1
H NMR of Acetylfentanyl citrate (18) S16
13
C NMR of Acetylfentanyl citrate (18) S17
1
H NMR of 2-(Thiophen-2-yl)ethyl methanesulfonate (19) S18
13
C NMR of 2-(Thiophen-2-yl)ethyl methanesulfonate (19) S19
1
H NMR of N-[2-(2-thienyl)ethyl]-4-piperidinone (20) S20
13
C NMR of N-[2-(2-thienyl)ethyl]-4-piperidinone (20) S21
1
H NMR of N-phenyl-1-(2-(thiophen-2-yl)ethyl)piperidin-4-amine (21) S22
13
C NMR of N-phenyl-1-(2-(thiophen-2-yl)ethyl)piperidin-4-amine (21) S23
1
H NMR of Thiofentanyl (10) S24
13
C NMR of Thiofentanyl (10) S25
1
H NMR of Thiofentanyl hydrochloride (23) S26
13
C NMR of Thiofentanyl hydrochloride (23) S27
1
H NMR of Thiofentanyl citrate (24) S28
13
C NMR of Thiofentanyl citrate (24) S29
1
H NMR of Acetylthiofentanyl (11) S30
13
C NMR of Acetylthiofentanyl (11) S31
1
H NMR of Acetylthiofentanyl hydrochloride (25) S32
13
C NMR of Acetylthiofentanyl hydrochloride (25) S33
1
H NMR of Acetylthiofentanyl citrate (26) S34
13
C NMR of Acetylthiofentanyl citrate (26) S35

S1
S2
S3
S4
S5
S6
S7
S8
S9
S10
S11
S12
S13
S14
S15
S16
S17
S18
S19
S20
S21
S22
S23
S24
S25
S26
S27
S28
S29
S30
S31
S32
S33
S34
S35

You might also like