PHARMACOLOGY

1. Anti-coagulants are:
a. Agents which inhibit synthesis of coagulating factors
b. Agents which inhibit the activity of coagulating factors
c. Agents which inhibit both synthesis and activity of coagulating factors
d. Agents which inhibit one of several pathways of platelet aggregation
2. Warfarin inhibit the:
a. Hepatic synthesis of factor II, IV, IX and X
b. Inhibit activity of factorIIa and Xa
c. Inhibit Thrombaxane A2 Synthesis
d. Inhibit Prostaglandin Synthesis
3. Dihydrofolate reducatse enzyme inhibitors include:
a. Trimethoprim
b. Pyrimethamine
c. Sulphonamides
d. Both a and b
4. Warfarin inhibit the reduction of
a. Vitamin A
b. Vitamin K
c. Vitamin C
d. Vitamin A
5. INR test is done for
a. Warfarin
b. Heparin
c. Aspirin
d. Clopidogrel
6. Vitamin K is antidote for
a. Aspirin
b. Warfarin
c. Heparin
d. Enoxaparin
7. Thrombolytic act by inhibiting
a. Direct or indirect conversion of plasminogen to plasmin
b. Fibrinogen to fibrin
c. Inactive thrombin to activated thrombin
d. All of above
8. Which of the following agents can be used to treat bleeding
a. Enoxapirin
b. Deltapirin
c. Tranexamic Acid
d. Abxaximab
9. Which of the following is not the mechanism of anti-platelet agents
a. Inhibit Cyclooxygenase I
 b. Inhibit Cyclooxygenase II
c. Inhibit ADP receptor
d. Inhibit GP IIa/IIIb receptors
10. Aspirin:
a. Reversibly inhibit the COX I enzyme
b. Irreversibly inhibit COX I enzyme
c. ADP receptor
d. ADP enzyme
11. ADP receptor blockers include
a. Clopidogrel
b. Aspirin
c. Warfarin
d. Heparin
12. Which of the following is true for Abciximab
a. Inhibit activation of coagulating factors
b. Inhibit oxidation of Vitamin K
c. Monoclonal antibody, inhibit GPIIb/IIa receptor
d. Inhibit thromboxane A2
13. Which of the following is not beta lactam anti-biotic
a. Penicillin
b. Cephalosporin
c. Monobactam
d. Vancomycin
14. Redman syndrome Is side effect of
a. Vancomycin
b. Aminoglycosides
c. Macrolides
d. Chloramphenicol
15. Dihydrofolate synthetase enzyme is inhibited by
a. Trimethoprim
b. Pyrimethamine
c. Sulphonamides
d. Both a and b
16. Chloramphenicol when administered to newborn may result into
a. Gray baby syndrome
b. Redman syndrome
c. Jaundice
d. Stevenson Johnsen syndrome
17. Anaphylactoid reactions are most commonly seen with
a. Betalactam antibiotic
b. Vancomycin
c. Azithromycin
d. Streptomycin
18. Transpeptidase enzyme is inhibited by which of the following groups
 a. Protein synthesis inhibitor
b. DNA synthesis Inhibitors
c. Folic Acid Synthesis inhibitors
d. Cell Wall Synthesis Inhibitors
19. Betalactam ring is key character of
a. Peniciilin
b. Cephalosporin
c. Monobactam
d. All of above
20. Stevenson jhonson syndrome may result as a adverse effect of
a. Aspirin
b. Cephalosporin
c. Monobactam
d. Carbapenem
21. Superinfection may result due to use of
a. Antifungals
b. Anti parasitic
c. Broad spectra anti-biotics
d. Anti malarial
22. MRSA and MRSE infections are treated with
a. Vancomycin
b. Cephalosporin
c. Azithromycin
d. None of above
23. Bacterial protein synthesis can be targeted by all of the following except
a. Clarithromycin
b. Streptomycin
c. Chlorampanicol
d. Doxyxycline
e. Vancomycin
24. tRNA-mRNA-Ribosomal complex formation can be inhibited by
a. aminoglycosides
b. tetracyline
c. quinolones
d. tetracyline
25. which of the following group of antibacterial cause tooth discoloration of teeth.
a. aminoglycosides
b. tetracyline
c. quinolones
d. tetracyline
26. “ which of the following SUFIX is added for Aminoglycosides:
a. Thromycin
b. Mycin
c. Cycline
 d. Floxacin
27. Patient is admitted in hospital for acute drug related neuromuscular paralysis. Which of the
following antibacterial can be more related for this adverse event
a. Streptomycin
b. Azithromycin
c. Chloramphenicol
d. Doxycycline
28. All of the following are adverse effect of aminoglycosides, except
a. Stunting growth
b. Ototoxic
c. Nephrotoxic
d. Neuromuscular paralysis
29. Misreading of bacterial mRNA at mRNA-tRNA-ribosomal complex is the mechanism of
e. Streptomycin
f. Azithromycin
g. Chloramphenicol
h. Doxycycline
30. Clarithromycin:
a. Inhibit translocation process
b. Cause misreading of mRNA
c. Inhibit transpeptidases
d. Inhibit formation of tRNA-mRNA- ribosomal complex
31. Which of the following group is contraindicated in hepatic patient
a. Macrolides
b. Penicillins
c. Cephalosporins
d. Aminoglycosides
e. Tetracyclines
32. All of the following are true, except:
a. Presence of multivalent cations decrease the absorption of tetracycline
b. Aminoglycosides can lead to oto-toxic effect
c. Chloramphenicol inhibit peptidyl transferase enzyme responsible for peptidoglycan cross
linking
d. Erythromycin inhibit translocation process in bacterial protein synthesis
33. Which of the following NSAIDs is used for its antiplatelet effect in cardiac patient
a. Ibuprofen
b. Clecoxib
c. Aspirin
d. Diclofenac
34. Antiplatelets agents belongs to all of the following groups, except:
a. Those which inhibit synthesis of vitamin K
b. ADP receptor antagonist
c. Thromboxane A2 synthesis inhibitor (inhibit COX)
d. GPIIb/IIIa receptor blocker
35. DNA gyrase and Topoismerases enzyme inhibitors include
a. Ciproflocxacin
b. Nalidixic acid
c. Kanamycin
d. Both a and b
36. Co-tramaxozle is combination of
a. Amoxacillin-calvulanic acid
b. Doxycycline-trimathoprim
c. Trimethoprim-sulphamethaxazole
d. Methacillin-trimathoprim
37. Co-amoxiclave is combination of
a. Amoxacillin-calvulanic acid
b. Doxycycline-trimathoprim
c. Trimethoprim-sulphamethaxazole
d. Methacillin-trimathoprim
38. Protamine sulfate is
a. Anti-dote for heparin
b. Anti-dote for warfarin
c. Anti-dote for aspirin
d. Anti-dote for tranxamenic acid
39. All of the following groups inhibit bacterial cell wall except
a. Aminoglycosides
b. Peniciilin
c. Cephalosporin
d. Monobactam
e. Carbapenams
40. Betalactam antibiotic inhibit
a. Cell wall synthesis
b. Protein synthesis
c. DNA synthesis
d. Folic Acid Synthesis
41. Gastric Acid is secretion by all of the following except
a. Acetylcholine
b. Prostaglandin
c. Gastrin
d. Histamine
42. H/K ATPase, also known as Proton Pump is inactivated by
a. Prostaglandin
b. Ach
c. Gastrin
d. Histamine
43. Which of the following receptors of Histamine are responsible for activation H/K ATPase in
gastric lumen
a. H1 Receptor
 b. H2 Receptor
c. H3 Receptor
d. H4 Receptor
44. Non streroidal Antiandrogen is side effect of
a. Cimitadine
b. Omeprazole
c. Sucralfate
d. Misoprostol
45. Patient visit to doctor, complaining chest development (gynostemia). Which of the following
drug is more responsible for this adverse effect
a. Cimitadine
b. Pantoprazole
c. Rabeprazole
d. Esomeprazole
46. Drugs that increase the pH of Gastric Lumen (decrease HCL)
a. Will decrease the absorption of drugs requiring acid media
b. Will increase the absorption of drugs requiring basic media
c. Will have no effect on absorption of acidic or basic media
d. Will increase the absorption of basic drugs
47. Prolong acid suppression therapy, results in decrease level of
a. Vit B1
b. Vit B2
c. Vit B12
d. Vit B6
48. Misoprostol is used for
a. NSAIDs induce ulcer
b. GERD
c. Basil and stimulated gastric ulcer
d. None of above
49. Which of the following term is true:
a. Misoprostol increase the level of HCL and decrease uterine contraction
b. Misoprostol increase the level of HCL and increase Uterine Contraction
c. Misoprostol decrease the level of HCL and increase uterine contraction
d. Both b and c
50. Mark the true statement
a. Alumanium hydroxide casue diarrhea
b. Alumanium hydroxide cause constipation
c. Magnesium hydroxide casue diarrhea
d. Both b and c
51. Triplet and quardiplet therapy is used for
a. Hypylori infection
b. Non H.Pylori ulcer
c. NSAIDs induced ulcer
 d. None of above
52. Triplet therapy include all of the following except
a. Bismuth subsalicylate
b. PPIs
c. Amoxacillin
d. Clarithromycin
53. Prostaglandin:
a. Decrease the release of HCL
b. Increase the release of HCL
c. Have no effect on HCL secretion
d. Non of above
54. Omeprazole belongs to
a. PPIS
b. H2 Receptor blocker
c. Mucosal Protectants
d. Ant Acids
55. Cimitidene :
a. Block H1 receptor
b. Block H2 Receptor
c. H/K+ ATPase
d. Proton Pump
56. 5HT3 antagonists are used for
a. Chemotherapy induce vomiting
b. Travelling sickness
c. Motion sickness
d. Morning sickness
57. Psyllium husk is used in constipation, work by
a. Bulk forming agent
b. Stimulant purgative
c. Osmotic purgative
d. Stool softener
58. Which of the following group increase the gastric and intestinal peristaltic movement
a. Bulk forming agent
b. Stimulant purgative
c. Osmotic purgative
d. Stool softener
59. Osmotic Laxative results in
a. Increasing the intestinal motality
b. Stool liquidity and increase fecal fluid
c. Increasing bulk forming
d. None of above
60. Castor Oil is
a. Bulk forming agent
b. Stimulant purgative
c. Osmotic purgative
d. Stool softener
61. In malarial parasite conversion of heme to hemozoin is inhibited by
a. Artemether
b. Chloroquine
c. Mefloquine
d. Quinene
62. Artemesins (anti malarial) kills the parasite
a. By production of free radical
b. By formation of leaky pors
c. Inhibiting transpeptidase
d. InhibitingDNA
63. Amphotericin is anti fungal drug and act by
a. Inhibiting Beta glucan
b. Inhibiting DNA and RNA
c. Inhibiting Ergosterol Synthesis
d. Inhibiting RNA polymerase
64. Bone Merrow suppression is side effect of
a. Inhibiting Beta glucan
b. Inhibiting DNA and RNA
c. Inhibiting Ergosterol Synthesis
d. Inhibiting protein synthesis
65. RNA and DNA synthesis in growing tumor is inhibited by all of the following except
a. Methotrexate
b. Flurouracil
c. Mercaptopurine
d. Platinum compounds
66. Taxane and Vinca alkaloids inhibit
a. Microtubuler assembly
b. DNA RNA synthesis
c. DNA and RNA polymerase
d. Protein synthesis
67. Hormonal analouges used in chemotherapy decrease the hormone dependent tumor
progression by
a. Physiological agonist
b. Physiological antagonist
c. Both physiological agonist and antagonist
d. Inhibit kinases
68. Non cell cycle specific anti-cancer drugs are used for
a. Slowing growing tumor
 b. Fast and rapidly growing tumor
c. Not used as anti cancer
d. Used for viral infection
69. Echinocandin (anti fungal)
a. Cause pore formation in fungal membrane
b. Inhibit beta glucan
c. Inhibit ergosterol
d. Inhibit formation of squalene epoxide
70. Nystin cause fungal cell disruption by
a. Cause pore formation in fungal membrane
b. Inhibit beta glucan
c. Inhibit ergosterol
d. Inhibit formation of squalene epoxide