PHARMACOLOGY - TEST 1

BDT II, UDOH II, BOH II, BSC PHYS III

(MPYA021, APPH201, APPH311)

Date: 31 MARCH 2014

Time : 1 Hour
Marks : 50

STUDENT INFORMATION:

i) Fill in on the answer sheet your surname, initials and student number.
ii) Mark with  beneath the surname, initials and student number the
appropriate letter or number.

INSTRUCTIONS:

SECTION A:
Answer this section on the provided answer sheet (questions 1- 20).20 marks

SECTION B:
Answer this section on the same answer sheet (questions 22-40). 20 marks

SECTION C:
Answer this section on the same answer sheet (questions 41-50) 10 marks

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 INSTRUCTIONS
SECTION A

STUDENT INFORMATION:

i) Fill in on the answer sheet your surname, initials and student number.
ii) Select the correct answers by marking with  the appropriate letter or
number.

ANSWERING THE QUESTIONS :

i) NOTE: One mark awarded for each correct answer and 0,5 mark subtracted for
each wrong answer.
ii) If the answer is true, mark column A. If the answer is false, mark column B.
iii) Each question corresponds to a similar number on the answer sheet.
iv) If both columns are marked, one mark will be subtracted.

e.g. Question Z:

Concerning drugs:

1. Theophylline is a beta-blocker
2. Atropine decreases mucus secretion

NOTE: REMEMBER TO MARK “A” TO INDICATE “TRUE”

AND “B” TO INDICATE “FALSE”

Answer Sheet:

A B C D E F
1.      
2.      

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SECTION A:
1. The most important route of drug elimination from the body is through the kidneys.
T
2. No drugs can be eliminated by the lungs. F
3. An agonist is a drug that combines with a receptor to produce a response. T
4. Drugs with a narrow therapeutic index is safe and common to give in doses in excess
of that which isminimally required to achieve a desired response. F
5. Propranolol is a selective β1 blocker F
6. Timolol is used to treat glaucoma T
7. Atropine is an antidote for an overdose of scopolamine F
8. Salbutamol causes bronchoconstriction. F
9. Sympathetic nervous stimulation results in contraction of the radial muscles in the iris
of the eye causing mydriasis T.
10. The last step in the synthesis of noradrenaline is the conversion of dopamine to
noradrenaline.T
11. Paracetamol has antitussive properties. F
12. Naloxone can reverse respiratory depression caused by a morphine overdose.
T
13. Pethidine stimulates the respiratory centre. F
14. Indomethacin has anti-inflammatory effects. T
15. The alternative antibiotic for penicillin allergic patients is erythromycin. T
16. A bacteriostatic drug kills all viable bacteria at therapeutic doses. F
17. Penicillin G is natural penicillin with an extended spectrum. F
18. Amoxicillin does not cross the blood-brain barrier except in the presence of
inflamed meninges. T
19. Empiric therapy is treatment given before the causative organism is identified. T
20. Aspirin is an example of a non-steroid anti-inflammatory drug T

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 INSTRUCTIONS
SECTION B

i) Choose the correct answer from the options under each question.

ii) No negative marking for this section.

iii) One mark will be awarded for each correct answer, no mark allocated for wrong or
unanswered questions.

iv) Each question corresponds to a similar number on the answer sheet.

EXAMPLE: Question X:

Which of the following are antibiotics:

1) Penicillin
2) Fanta
3) Coca Cola
4) Ampicillin
5) Tab

A = 1,2 B = 2,3 C = 3,4 D = 4,5 E = 1,4

Penicillin and ampicillin are antibiotics, therefore the correct answer is E.

Mark E on the answer sheet.

A B C D E

1.     

SECTION B:

21. Which of the following is NOT an action of the body on a drug?

1. Absorption
2. Distribution
3. Metabolism
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4. Excretion
5. Side effects

A=1 B=2 C=3 D=4 #E = 5

22. The following can be classified as a parenteral route of drug

administration:
1. Oral
2. Intramuscular
3. Subcutaneous
4. Rectal
5. Sublingual

A = 1,2 B = 1,4,5 C = 1,3,5 #D = 2,3 E = All of

the above

23. The effect of a drug on the body is increased:

1. When the concentration of drug is increased at the receptor site
2. If the dose of the administered drug is decreased
3. When the absorption of the drug is increased
4. When the drug is weakly absorbed
5. When the drug is metabolized

A = 1,2,3 B = 2,3,4 C = 4,5 D = 3,4,5 #E = 1,3

24. The magnitude of a drug effect depends on.

1. Concentration of the drug at receptor site
2. Dose of drug administered
3. Absorption of the drug
4. Distribution of the drug
5. Metabolism of the drug

A=1 B = 1,2 C = 1,2,3 D = 1,2,3,4 # E = 1,2,3,4,5

25. A patient with organophosphate poisoning requires a cholinergic

antagonist. Namely:
1. Atropine
2. Neostigmine
3. Pilocarpine
4. Adrenaline
5. Paracetamol

#A = 1 B=2 C=3 D=4 E=5

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26. Acetylcholine cause the following effects:
1. bronchodilation
2. vasodilation
3. mydriasis
4. increased heart rate
5. smooth muscle contraction

A =1,3 B = 1,5 C = 3,4 #D = 2,5 E = 4,5

27. The following drugs are neuromuscular blockers:

1. Rocuronium
2. Ipratropium
3. Pancuronium
4. Atropine
5. Vecuronium

#A =1,3,5 B = 1,5 C = 3,4 D = 1,2,4 E = 1,4,5

28. The following are longer acting β2 agonists:

1. Salbutamol
2. Clonidine
3. Salmeterol
4. Formoterol
5. Terbutaline

A =1,3,5 #B = 3,4 C = 1, 2,4 D = 1,2 E = 1,4,5

29. Actions of adrenaline (epinephrine) include:

1. Increased systolic blood pressure
2. Increased cardiac output
3. Vasoconstriction
4. Mydriasis
5. Contraction of the bladder detrusor muscle

A = 1,2,3 B = 1,3,5 C = 1,2,3,5 D = 3,4,5 #E = All of the above

30. Which of the following drugs has/have anti-inflammatory effects?
1. Aspirin
2. Ibuprofen
3. Indomethacin
4. Paracetamol
5. Codeine

A=3 B=1 #C = 1,2,3 D = 4,5 E = 1,3,5

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31. Naloxone will be effective in reversing the toxic effects of the following
drugs:
1. Aspirin
2. Pethidine
3. Indomethacin
4. Fentanyl
5. Morphine

A = 1,2,3 B = 1,3,4 C = 1,3 D = 4,5 #E = 2,4,5

32. Which of the following drug/drugs has/have anti-platelet effects?

1. Aspirin
2. Ibuprofen
3. Indomethacin
4. Paracetamol
5. Codeine

A=3 #B = 1 C = 1,2,3 D = 4,5 E = All of the above

33. The following are side effects of opioid analgesics:

1. Hypertension
2. Respiratory depression
3. Cough
4. Emesis
5. Urinary retention.

A = 1,2,3 B = 3,4,5 C = #2,4,5 D = 1,4,5 E = 2,3,4

34. Which of the following statements are correct:

1. Opioids are addictive substances
2. Certain opioids can be used to treat nausea and vomiting
3. Most opioids cause respiratory depression
4. Opioids are contra-indicated in patients with terminal cancer
5. Pethidine can be combined with pentazocine.

A = 1,2 #B = 1,3 C = 4,5 D =2,5 E = 2,4

35. Which of the following are aminoglycosides:

1. Erythromycin
2. Gentamicin
3. Azithromycin
4. Amikacin
5. Penicillin

A = 1,2 B = 3,5 C = 4,5 #D = 2,4 E = 1,5

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36. The following antimicrobials are classified as bacterial protein synthesis
inhibitors:
1. Erythromycin
2. Imipenem
3. Doxycycline
4. Amikacin
5. Cefazolin

A = 1,2,3 #B = 1,3,4 C = 2,3,4 D = 1,2,5 E = 1,3,5

37. Adverse effects of antibacterials include the following:

1. Aminoglycosides - nephrotoxicity
2. Ethambutol – loss of hearing
3. Doxycycline – renal impairment
4. Tetracyclines - stunted growth in children
5. Chloramphenicol - grey baby syndrome

A = 1,2,3 #B = 1,4,5 C =1,2,4 D = 3,4,5 E = 1,3,4

38. The sites of infection that are not readily accessible to most
antimicrobials:
1. Gastrointestinal tract
2. Bone
3. Prostate gland
4. Brain
5. Liver.

A = 1,2,3 B = 1,3,5 #C = 2,3, 4 D = 2,4,5 E = 3,4,5

39. The following statements are true about amoxicillin:
1. It is an extended-spectrum penicillin
2. It is completely absorbed when administered orally
3. It is used as prophylaxis for risk patients undergoing oral surgical procedures
4. It reduces the efficacy of oral contraceptives
5. It is resistant to β-lactamases.

#A = 1,2,3,4 B = 2,3,4,5 C = 1,2,3,5 D = 1,2,4,5 E = All of the above

40. Factors that reduce the absorption of tetracycline:

1. Oral contraceptives
2. Dairy food
3. Iron supplements
4. Aluminium antacids
5. Vitamin C (ascorbic acid)

A = 1,2,3 #B = 2,3,4 C = 1,3,4 D = 1,2,4,5 E = 2,3,5

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 INSTRUCTIONS
SECTION C

STUDENT INFORMATION:

i) Fill in on the sheet provided your course, name, initials and student
number.

ANSWERING THE QUESTIONS:

i) Answer the questions by writing the correct single word, term or name in the
space
provided.

ii) NOTE: No negative marking.

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SECTION C:

Course: BDT II, BOH II, BSC PHYS III TEST 1

Date: 31 MARCH 2014

Student Name: ________________________________Student No: _______________________

Answer the following questions by writing the correct single word, term or
name.

41. Name the process by which drugs are removed from the body in urine, bile and
faeces. (1)
___________________________________________________________________
42. The section of pharmacology which refers to the action of drugs on the body.
(1) __________________________________________________________________
43. A term that describes the fraction of administered drugs that reaches the systemic
circulation. (1)
__________________________________________________________________
44. Name two cholinergic receptor types
(2)
_____________________________ __________________________________
45. The antidote that is used to treat paracetamol overdose.
(1)
__________________________________________________________________
46. What is the common cause of death with opioid overdose?
(1)
__________________________________________________________________
47. A tetracycline which is suitable to use in renal impairment
(1)
____________________________________________________________________
48. The drug causes gray baby syndrome in neonates.
(1)
___________________________________________________________________
49. Tetracyclines should not be used by women during
(1)
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 ___________________________________________________________________

END
MEMO
SECTION C:

Course: BDT II, BOH II, BSC PHYS III TEST 1

Date: 31 MARCH 2014

41. Name the process by which drugs are removed from the body in urine, bile and
faeces. (1)
Elimination
42. The section of pharmacology which refers to the action of drugs on the body.
(1) Pharmacodynamics
43. A term that describes the fraction of administered drugs that reaches the systemic
circulation. (1)
Bioavailability
44. Name two cholinergic receptor types
(2)
Muscarinic and nicotinic receptors
45. The antidote that is used to treat paracetamol overdose.
(1)
N-acetylcysteine
46. What is the common cause of death with opioid overdose?
(1)
Respiratory depression and collapse.
47. A tetracycline which is suitable to use in renal impairment
(1)
Doxycycline
48. The drug causes gray baby syndrome in neonates.
(1)
Chloramphenicol

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49. Tetracyclines should not be used by women during
(1)
lactation / pregnancy

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