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 RRB PHARMACIST
Exam pattern
Subjects No of Questions Marks Alloted
Professional ability 70 70
General awareness 10 10
General arithmetic, general 10 10
intelligence and reasoning
General science 10 10
TOTAL 100 100
PHARMA SUBJECTS
PHARMACEUTICS

PHARMACEUTICAL CHEMISTRY

PHARMACOGNOSY

BIOCHEMISTRY AND CLINICAL PATHOLOGY

HUMAN ANATOMY AND PHYSIOLOGY

 HEALTH EDUCATION & COMMUNITY
PHARMACY

PHARMACOLOGY & TOXICOLOGY

DRUG STORE AND BUSINESS MANAGEMENT

PHARMACEUTICAL ANALYSIS

PHYSICAL PHARMACEUTICS

PHARMACEUTICAL MICROBIOLOGY

BIOPHARMACUTICS AND PHARMACOKINETICS

 COSMETIC SCIENCE

NOVEL DRUG DELIVERY SYSTEM

 PHARMACEUTICS-I
Introduction of different dosage forms Extraction and Galenicals

Introduction to Pharmacopoeias Heat process

Metrology Distillation
Packaging of pharmaceuticals Introduction to drying process
Size reduction Sterilization
Size separation Processing of Tablets
Mixing and Homogenization Processing of Capsules
Clarification and Filtration Study of immunological products like sera,
vaccines, toxoids & their preparations.
 PHARMACEUTICAL CHEMISTRY
1.(A) Acids, bases and buffers: Boric acid, Hydrochloric acid, Strong Ammonium hydroxide,
Calcium hydroxide, Sodium hydroxide and official buffers.
(B) Antioxidants: Hypophosphorous acid, Sulphur dioxide, Sodium bisulphate, Sodium meta
bisulphite, Sodium thiosulphate. Nitrogen and Sodium nitrite.
(C) Gastrointestinal agents:
i. Acidifying agents
ii. Antacids
iii. Protective and Adsorbents
iv. Saline cathartics
(D) Topical Agents:
i. Protective
ii. Antimicrobials and Astringents
iii. Sulphur and its compounds
iv. Astringents
(E) Dental Products:
(F) Inhalants
(G) Respiratory stimulants
(H) Expectorants and Emetics
(I) Antidotes: Sodium nitrite.
2. Major Intra and Extra cellular electrolytes:
A. Electrolytes used for replacement therapy
B. Physiological acid-base balance and electrolytes used
C. Combination of oral electrolyte powders and solutions.
3. Inorganic official compounds of Iron, lodine and Calcium, Ferrous Sulphate and Calcium
Gluconate.
4. Radio pharmaceuticals and contrast media:
5. Quality control of Drugs and pharmaceuticals
6. Identification tests for cations and anions as per Indian Pharmacopoeia.
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 PHARMACOGNOSY
1. Definition, history and scope of Pharmacogonosy including indigenous
system of medicine.
2. Various systems of classification of drugs of natural origin.
3. Adulteration and drug evaluation; significance of Pharmacopoeial
standards.
4. Brief outline of occurrence, distribution, outline of isolation,
identification tests, therapeutic effects and pharmaceutical application
of alkaloids, terpenoids, glycosides, volatile oils, tannins and resins.
5. Occurrence, distribution, organoleptic evaluation, chemical
constituents including tests wherever applicable and therapeutic
efficacy of following categories of drugs.
(a) Laxatives- Aloes, Rhubarb, Castor oil Ispaghula, Senna.
(b) Cardiotonics - Digitalis, Arjuna.
(c) Carminatives & G.I. regulators: Umbelliferous fruits, Coriander,
Fennel Ajowan, Cardamom, Ginger, Black pepper, Asafoetida, Nutmeg,
Cinnamon, Clove.
(d) Astringents - Catechu.
(e) Drugs acting on nervous system: Hyoscyamus, Belladonna, Aconite,
Ashwagandha, Ephedra, Opium, Cannabis, Nux-vomica.
(f) Antihypertensive - Rauwolfia.
(g) Antitussives - Vasaka, Tolu balsam, Tulsi.
(h) Antirheumatics- Guggal, Colchicum.
(i) Antitumour - Vinca.
(j) Antileprotics- Chaulmoogra oil
(k) Antidiabetics- Pterocarpus, Gymnema sylvestro.
(l) Diuretics- Gokhru, Punarnava,
(m) Antidysenterics- Ipecacuanha,
(n) Antiseptics and disinfectants- Benzoin, Myrrh, Neem, Curcuma.
(o) Antimalarials- Cinchona.
(p) Oxytocics- Ergot
(q) Vitamins- Shark liver oil and Amla.
(r) Enzymes- Papaya, Diastase, Yeast
(s) Perfumes and flavoring agents- peppermint oil, Lemon oil, orange oil,
lemon grass oil, sandal wood
(t) Pharmaceutical aids- Honey, Arachis oil starch, kaolin, pectin, olive oil
Lanolin, Beeswax, Acacia, Tragacanth, sodium Alginate, Agar, Guar gum,
Gelatin.
(u) Miscellaneous- Liquorice, Garlic, picrorhiza, Diascorea, Linseed,
shatavari, shankhpushpi, pyrethrum, Tobacco.
6. Collection and preparation of crude drugs for the market as
exemplified by ergot, opium, rauwolfia, digitalis and senna.
7. Study of source, preparation and identification of fibers used in
sutures and surgical dressings cotton, silk, wool and regenerated
fibers.
8. Gross anatomical studies of Senna, Datura, Cinnamon, Cinchona,
Coriander, Fennel Clove, Ginger, Nux-vomica, Ipecacuanha.
 BIOCHEMISTRY & CLINICAL
PATHOLOGY
Introduction to Biochemistry

Proteins & Amino Acids

Brief chemistry and role of carbohydrates, classification,

qualitative tests, Diseases related to carbohydrate metabolism

Brief chemistry and role of lipids, classification and qualitative

tests. Diseases related to lipids metabolism
 Brief chemistry and role of vitamins and coenzymes

Role of minerals and water in life processes.

Enzymes

Brief concept of normal and abnormal metabolism of proteins,

carbohydrate and lipids.
Introduction to pathology of blood and urine

Lymphocytes and platelets, their role in health

1 and disease

Erythrocytes-Abnormal cells and their

2 significance

Abnormal constituents of urine and their

3 significance in diseases
HUMAN ANATOMY AND
PHYSIOLOGY
Scope of Anatomy and physiology: Definition of various terms
used in Anatomy.

Structure of cell function of its components

Elementary Tissues

Structure and function of Skeleton

Composition of blood functions of blood elements

 Name and functions of lymph glands

Structure and functions of various parts of the heart

Various parts of respiratory system and their functions, physiology of

respiration

Various parts of urinary system and their functions, structure and

functions of kidney

Structure of skeletal muscle, physiology of muscle contraction

Various parts of central nervous system, brain and its parts, functions
and reflex action.

Elementary knowledge of structure and functions of the organs of

taste, smell ear, eye and skin. Physiology of pain
 Digestive system

Endocrine glands and Hormones. Location of glands, their

hormones and functions

• Reproductive System: Physiology and Anatomy of

Reproductive system
HEALTH EDUCATION & COMMUNITY
PHARMACY
Concept of Health

Nutrition and Health

Demography & family planning

First aid

Environment and health

Fundamental principles of microbiology

Communicable diseases: Causative agents, mode of transmission and
prevention

Respiratory infections-chicken pox, measles, influenza,

diphtheria, whooping cough and tuberculosis

Intestinal infection: poliomyelitis, Hepatitis, cholera,

Typhoid food poisoning, Hookworm infection

Arthropod borne infections: plague, Malaria, filariases

Surface infection: Rabies, Trachoma, Tetanus, Leprosy

Sexually transmitted diseases: Syphilis, Gonorrhoea,

AIDS.

Non-communicable diseases: Causative agents, prevention, care and

control: Cancer, Diabetes, Blindness, Cardiovascular disease.
 PHARMACEUTICS-II
1. Dispensing Pharmacy:
i. Prescriptions
ii. Incompatibilities in prescriptions
iii. Posology
2. Dispensed Medications:
i. Powders
ii. Liquid oral Dosage form
a. Monophasic -
Review of the following monophasic liquids with details of formulation
and practical methods
Liquids for internal Liquids for external administration or
administration used on mucous membranes
Mixtures and concentrates Gargles
Syrups Mouth washes, Throat-paints, Douches
Elixirs Ear Drops, Nasal drops/sprays,
Liniments, Lotions

b. Biphasic Liquid Dosage Forms:

i. Suspensions
ii. Emulsions
c. Semi-Solid Dosage Forms:
i. Ointments
ii. Pastes
iii. Jellies
iv. Suppositories and Pessaries
3. Dental and cosmetic preparations
4. Sterile Dosage forms
a. Parenteral dosage forms
b. Sterility testing
c. Ophthalmic products
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 PHARMACEUTICAL CHEMISTRY-II
1. Introduction to the nomenclature of organic chemical systems with
particular reference to hetero-cyclic system containing up to 3 rings.
2. The chemistry of following pharmaceutical organic compounds covering
their nomenclature, chemical structure, uses and the important physical and
chemical properties –
Antiseptics and Disinfectants ,Sulphonamides , Antileprotic Drugs , Anti-
tubercular Drugs , Antimoebic and Anthelmintic Drugs , Antibiotics ,
Antifungal agents , Antimalarial Drugs, Tranquilizers , Hypnotics , General
Anaesthetics , Antidepressant Drugs
Analeptics , Adrenergic drugs , Adrenergic antagonist, Cholinergic
Drugs , Cholinergic Antagonists , Diuretic Drugs , Cardiovascular Drugs ,
Hypoglycemic Agents , Coagulants and Anti coagulants, Local
Anaesthetics: Lignocaine", Procaine", Benzocaine. ,

Histamine and anti-Histaminic Agents , Non-steriodal anti-

inflammatory agents , Thyroxine and Antithyroids , Diagnostic Agents,
Anticonvulsants, cardiac glycosides, Antiarrhythmic, Antihypertensives
& Vitamins, Steroidal Drugs,Anti-Neoplastic Drugs
 PHARMACOLOGY & TOXICOLOGY
❑Introduction to pharmacology, scope of pharmacology.
❑Routes of administration of drugs, Various processes of absorption
of drugs and the factors affecting them. Metabolism, distribution
and excretion of drugs.
❑General mechanism of drugs action and their factors which modify
drugs action.
❑Pharmacological classification of drugs. The discussion of drugs
should emphasize the following aspects.
(i) Drugs acting on the central Nervous system:
✓ General anaesthetics- adjunction to anaesthesia, intravenous
anaesthetics.
✓ Analgesic antipyretics and non-steroidal anti-inflammatory
drugs-Narcotic analgesics, Anti-rheumatic and anti-gout
remedies, Sedatives and Hypnotics, psychopharmacological
agents, anticonvulsants, analeptics.
✓ Centrally acting muscle relaxants and anti-parkinsonism
agents.
(ii) Local anesthetics.
(iii) Drugs acting on autonomic nervous system.
a. Cholinergic drugs, Anticholinergic drugs,
anticholinesterase drugs.
b. Adrenergic drugs and adrenergic receptor blockers.
c. Neurone blockers and ganglion blockers.
d. Neuromuscular blockers, used in myasthenia gravis.
(iv) Drugs acting on eye: Mydriatics, drugs used in glaucoma.
(v) Drugs acting on respiratory system:
(vi) Antacids
(vii) Cardio vascular drugs:
(viii) Drugs acting on the blood and blood forming organs.
(ix) Drugs affecting renal function: Diuretics and anti-diuretics.
(x) Hormones and hormone antagonists
(xi) Drugs acting on digestive system
(xii) Chemotherapy of microbial diseases
(xiii) Chemotherapy of protozoal diseases: Anthelmintic drugs.
(xiv) Chemotherapy of cancer.
(xv) Disinfectants and antiseptics.
PHARMACEUTICAL JURISPRUDENCE
Origin and nature of pharmaceutical legislation
in India

• Principles and significance of professional Ethics

Pharmacy Act, 1948

The Drugs and Cosmetics Act,

The Drugs and Magic Remedies

Narcotic Drugs and psychotropic substances Act,

1985
Brief introduction to the study of the following acts

Latest Drugs (price control) order in force

Poisons Act 1919(as amended to date)

• Medicinal and Toilet preparations (excise Duties)

Act, 1955 (as amended to date)
Medical Termination of Pregnancy Act, 1971(as
amended to date)
 DRUG STORE AND BUSINESS
MANAGEMENT
✓ Introduction- Trade, Industry and commerce, Functions and
subdivision of commerce, Introduction to Elements for
Economics and Management.
✓ Forms of Business Organizations
✓ Channels of Distribution.
✓ Drug House Management
✓ Inventory Control
✓ Sales promotion, Market Research, Salesmanship, qualities of a
salesman, Advertising and Window Display.
✓ Banking and Finance
✓ Cash Book.
✓ General Ledger and Trial Balance.
✓ Profit and Loss Account and Balance Sheet.
✓ Simple techniques of analyzing financial statements.
Introduction to Budgeting.
 HOSPITAL & CLINICAL PHARMACY
PART I : HOSPITAL PHARMACY
1. Hospital- Definition, Function, classifications based on various criteria, organization,
Management and health delivery system in India.
2. Hospital Pharmacy:
a) Definition
b) Functions and objectives of Hospital pharmaceutical services.
c) Location, Layout, Flow chart of materials and men.
d) Personnel and facilities requirements including equipments based on individual and
basic needs.
e) Requirements and abilities required for Hospital pharmacists.
3. Drug Distribution system in Hospitals:
a) Out-patient service
b) In-patient services- Types of services detailed discussion of unit Dose system, Floor
ward stock system, satellite pharmacy services, central sterile services, Bed side
pharmacy.
4. Manufacturing:
a) Economical considerations, estimation of demand
b) Sterile manufacture- large and small volume parenteral,
facilities, requirements, layout production planning,
man-power requirements.
c) Non-sterile manufacture- Liquid orals, externals, Bulk
concentrates.
d) Procurement of stores and testing of raw materials.
e) Nomenclature and uses of surgical instruments and
Hospital Equipment's and health accessories.
5. P.T.C. (Pharmacy Therapeutic Committee)
6. Hospital Formulary system and their organization, functioning,
composition.
7. Drug Information service and Drug Information Bulletin.
8. Surgical dressing like cotton, gauze, bandages and adhesive tapes
including their pharmacopoeial tests for quality. Other hospital
supply eg. I.V.sets, B.G sets, Ryals tubes, Catheters, Syringes, etc.
 PART II : HOSPITAL PHARMACY
A. Introduction to Clinical pharmacy practice
B. Modern dispensing aspects- Pharmacists and patient counseling and
advice for the use of common drugs, medication history.
C. Common daily terminology used in the practice of Medicine.
D. Disease, manifestation and Patho-physiology including salient
symptoms to understand the disease like Tuberculosis, Hepatitis,
Rheumatoid Arthritis, Cardio-vascular diseases, Epilepsy, Diabetes,
Peptic Ulcer, Hypertension.
E. Physiological parameters with their significance.
F. Drug Interactions:
a) Definition and introduction.
b) Mechanism of Drug Interaction.
c) Drug-drug interaction with reference to analgesics, diuretics,
cardiovascular drugs, Gastro intestinal agents. Vitamins and
Hypoglycemic agents.
d) Drug-food interaction.
G. Adverse Drug Reaction:
a) Definition and significance.
b) Drug-Induced diseases and Teratogenicity.
H. Drugs in Clinical Toxicity
I. Drug dependences, drug abuse, addictive drugs and their treatment,
complications.
G. Bio-availability of drugs, including factors affecting it.
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