MIDTERM PRACTICE EXAM – HEMATOLOGY2-LEC
1. Which of the following factors will activate factor XI?
A. Stuart Factor
B. Fibrinogen
C. Hageman Factor
D. Plasma Thromboplastin Antecedent
2. Thrombin-Thrombomodulin complex is necessay for the activation of:
A. Protein C
B. Antithrombin
C. protein S
D. Factor V and VIII
3. Factor I deficiency will affect APTT and PT *
A. True
B. False
4. Scott Syndrome will affect which of the following?
A. Platelet Adhesion
B. Vasoconstriction
C. Secondary Hemostasis
D. Fibrinolysis
5. Factor V is a cofactor to factor X to activate factor II *
A. True
B. False
6. Hemolytic Uremic syndrome is associated with:
A. Fever and thrombocytosis
B. Granulocytosis
C. E. coli
D. Leukocytosis
7. Which of the following is a chracteristic of acute idiopathic thrombocytopenic purpura?
A. Spontaneous remission within a few weeks
B. Nonimmune platelet destruction
C. Insidious onset
D. Predominantly seen in adults
8. The defect characterizing Gray's Syndrome:
A. Platelet Adhesion
B. Dense Granule
C. Alpha Granule
D. Coagulation defect
9. Which of the following test results is normal in a patient with classic von Willebrand's disease?
A. Bleeding Time
B. APTT
C. VWF Level
D. Platelet Count
10. Hereditary hemorrhagic telangectasia is a disorder of:
A. Platelets
MIDTERM PRACTICE EXAM – HEMATOLOGY2-LEC
B. Clotting proteins
C. Fibrinolysis
D. Connective tissue
11. Several hours after birth, a baby boy develops petechiae and a hemorrhagic diathesis. Platelet
count i8,000/uL. What is likely the explanation?
A. Drug induced thrombocytopenia
B. Secondary Thrombocytopenia
C. Isoimmune Neonatal Thrombocytopenia
D. Neonatal DIC
12. APTT is used to?
A. Monitor Heparin Therapy
B. Evaluate the Common Pathway
C. Both
D. None
13. Platelet abnormality will affect Both Bleeding Time and Clotting Time
A. True
B. -False
True
14. Lumi-aggregation measures:
A. Platelet aggregation
B. Aggregation and ATP release
C. Platelet Adhesion
D. GP 1B
15. When performing platelet aggregation studies, whcich is most likely associated with Bernard
Soulier Syndrome:
A. Normal to Collagen, ADP and Ristocetin
B. Normal to Epinephrine, Decreased to Ristocetin
C. Normal to Epinephrine and Ristocetin, decreased with collagen
D. Decreased with ADP
16. No bleeding is observed in deficiency of which of the following factors?
A. II
B. XII
C. IX
D. VIII
17. Neurologic findings may be commonly associated with which of the following disorders?
A. HUS
B. TTP
C. ITP
D. PTP
18. Aspirin prevents platelet aggregation by inhibiting the action of which enzyme?
A. TXA2 Synthase
B. Prostacyclin Synthase
C. Cyclooxygenase
D. Phospholipase
MIDTERM PRACTICE EXAM – HEMATOLOGY2-LEC
19. Which of the following Inhibitors inhibit Factor IIa?
A. Protein C
B. Antithrombin III
C. Both
D. Neither
20. Factor XIII is activated by which factor?
A. IIa
B. Va
C. Xa
D. Fibrinogen
21. Thrombocytopenia may be associated with
A. Postsplenectomy
B. Hypersplenism
C. Acute Blood loss
D. Myeloproliferation
22. Which of the following is associated with post transfusion purpura?
A. Nonimmune thrombocytopenia/ alloantibodies
B. Immune mediated thrombocytopenia/ Alloantibodies
C. Both of the above
D. Autoantibodies
23. Which of the following tests is most likely to be abnormal in patients taking Aspirin?
A. Platelet morphology
B. Platelet Count
C. Bleeding Time
D. Prothrombin Time
24. What role does vitamin K play in the Prothrombin group?
A. Provides surface on which thr proteolytic reaction occurs
B. Protects them from inapprpriate activation by compounds such as thrombin
C. Accelerates the binding of the serine protease and their cofactors
D. Carboxylates the factors to allow calcium binding
25. Thrombotic thrombocytopenic prpura is characterized by:
A. prolonged Aptt
B. Prolonged PT
C. Thrombocytosis
D. Increased platelet aggregation
26. Which of the following is correct regarding acquired thrombotic thrombocytopenic purpura?
A. Autoimmune Disease
B. Decreased VWF
C. Decreased Platelet Aggregation
D. Decreased Platelet Adhesion
27. What is the second phase of secondary Hemostasis?
A. Contact Phase
B. Activation of factor VII
C. Activation of factor X
MIDTERM PRACTICE EXAM – HEMATOLOGY2-LEC
D. Formation of Fibrin Clot
28. Which of the Following Factors is used only in the Extrinsic Coagulation Pathway?
A. II
B. VII
C. V
D. VIII
29. Thiazide diuretics results to:
A. Decreased Platelet Production
B. Decreased Platelet survival
C. Both
D. Neither
30. TAFI target protein:
A. TFPI
B. Fibrinogen
C. Fibrin
D. VwF
31. Which step requires calcium?
A. Factor VII activation
B. Factor XII activation
C. Factor XIII activation
D. Factor I activation
32. Giant platelet is associated with which condition:
A. Bernard Soulier Syndrome
B. Glanzmann's Thrombasthenia
C. Gaucher's Disease
D. All of the choices
33. What clotting factors are inhibited by Protein S?
A. V and X
B. V and VIII
C. VIII and IX
D. VIII and X
34. Which of the following coagulation factors is considered to be labile?
A. II
B. III
C. V
D. VII
35. Bleeding Time is used to evaluate the activity of:
A. Platelets
B. Prothrombin
C. Factor XIII
D. Labile Factor
36. Factor XIII is a serine protease *
A. True
B. False
MIDTERM PRACTICE EXAM – HEMATOLOGY2-LEC
37. A protein that plays a vital role in both coagulation and platelet aggregation:
A. I
B. XI
C. VIII
D. IX
38. Coagulation Factors affected by Coumarin Drugs:
A. VIII, IX, and X
B. I, II, V and VII
C. II, VII, IX and X
D. II, V, and VII
39. Platelet aggregation response for Glannzmann's Thrombasthenia:
A. Normal to ADP and Ristocetin, decreased to Collagen
B. Normal aggregation to collagen, Decreased to ADP and Ristocetin
C. Normal to ADP, decreased to ristocetin
D. Normal to Ristocetin, Decreased to Epinephrine
40. True of TTP and DIC:
A. APTT prolonged in DIC
B. Schistocytes are present in DIC
C. Platelet is decreased in TTP
D. PT is decreased in DIC
41. The APTT is sensitive to adeficiency of which clotting factor?
A. Calcium
B. X
C. Both
D. None
42. Which statement regarding protein C is correct?
A. Vitamin K independed
B. Fibrinogen activated
C. activates V and VIII
D. Activity is enhanced by Protein S
