1.
Siderotic granules are composed of:
a. DNA
b. RNA
c. iron
d. mitotic spindle
2. A pale blue body that is composed of RNA describes a:
a. auer rod
b. dohle body
c. vacuole
d. cabot ring
3. The most appropriate test for hereditary spherocytosis is:
a. sucrose hemolysis
b. heat instability test
c. DAT
d. osmotic fragility
4. Thalassemias are characterized by:
a. structural abnormalities in the hemoglobin molecule
b. absence of iron in hemoglobin
c. decreased rate of globin synthesis
d. decreased rate of heme synthesis
5. The WBC feature most characteristic of pernicious anemia is:
a. basophilic stippling
b. giant megakaryocytes
c. ringed sideroblasts
d. hypersegmentation
6. All of the findings listed below may be seen in acquired hemolytic
anemias of the autoimmune variety. The one considered to be the
MOST characteristic is:
a. increased osmotic fragility
b. leukopenia and thrombocytopenia
c. schistocytes
d. positive direct antiglobin test
7. In an uncomplicated case of severe iron deficiency anemia, which
of the following represents the typical pattern of results:
a. serum iron decreased, serum TIBC increased, % saturation decreased, serum
ferritin increased
b. serum iron decreased, serum TIBC decreased, % saturation decreased, serum
ferritin decreased
c. serum iron decreased, serum TIBC increased, % saturation decreased, serum
ferritin decreased
d. serum iron decreased, serum TIBC decreased, % saturation increased, serum
ferritin increased
8. What qualitative term is characteristically used to describe the
peripheral blood smear in aplastic anemia:
a. thrombocytopenia
b. pancytopenia
c. leukocytosis
d. erythrocytosis
9. The anemia of thalassemia is morphologically characterized as
_________ anemia:
a. macrocytic/hyperchromic
b. microcytic/hypochromic
c. normocytic/normochromic
d. microcytic/Normochromic
10. A 30 year old pregnant female arrives for her 3 month check-up.
She complains of fatigue, nausea and vomiting. The doctor states
that all of the symptoms can be associated with pregnancy but the
doctor orders a CBC. The results are as follows:
WBC count 5.5 x 109/L
RBC count 3.7 x 1012/dL
Hgb 10.8 gm/dL
Hct 32.7%
MCV 76 fL
MCH 22 pg
MCHC 30%
RDW 15%
Retic 0.6%
Morphology observed:
Poikilocytosis 1+
Which of the following disorders is consistent with the laboratory profile and history:
a. megaloblastic anemia
b. iron deficiency anemia
c. sideroblatic anemia
d. beta thalassemia minor
11. While observing a peripheral blood smear the MT noticed RBCs
that resembled a burr cell but the projections were randomly
spaced and spike-like, the RBC also had no central pallor. Which
of the following fits the description:
a. spherocyte
b. schistocyte
c. acanthocyte
d. codocyte
12. The most common form of childhood leukemia is:
a. acute lymphoblastic
b. acute myeloid
c. chronic lymphocytic
d. chronic myelogenous
13. In polycythemia vera, the hemoglobin, hematocrit, RBC count are
usually all:
a. elevated
b. normal
c. decreased
d. none of the above
14. Which of the following may be used to stain neutral fats and
phospholipids:
a. myeloperoxidase
b. Sudan black B
c. periodic acid Schiff
d. Wright stain
15. Which of the following tests can be useful in differentiating
leukemoid reactions from chronic myeloid leukemias:
a. myeloperoxidase stain
b. Sudan black B stain
c. leukocyte alkaline phosphatase stain
d. tartrate-resistant acid phosphatase stain
16. Auer rods are most likely present in which of the following:
a. hereditary spherocytosis
b. acute myeloid
c. chronic lymphoid
d. chronic myeloid
17. The following results were obtained:
WBC 8.0 x 109/L
RBC 3.7 x 1012/L
Hgb 10.8 gm/dL
Hct 32.7%
PLT 950 x 109/L
These results are consistent with:
a. chronic granulocytic leukemia
b. acute nonlymphocytic leukemia
c. polycythemia vera
d. essential thrombocythemia
18. The results on a patient are:
These results reflect :
A. thrombophilia
B. Factor IX deficiency
C. heparin
D. warfarin
19. The morphologic hallmark of Hodgkin's disease is a peculiar cell
called the ______ cell.
a. Ann Arbor
b. Reed-Sternberg
c. hairy cell
d. Sezary cell
20. Which of the following is characteristic of Bernard-Soulier disease:
a. giant platelets
b. normal bleeding time
c. increased platelet count
d. none of the above
21. The APTT:
a. tests the extrinsic coagulation pathway
b. monitors coumadin therapy
c. requires tissue thromboplastin
d. monitors heparin therapy
22. The following lab results were obtained for a patient with an
inherited autosomal dominant trait:
Bleeding time - prolonged
PT - normal
APTT - increased
Platelet count - normal
These findings are most consistent with:
a. Factor VIII deficiency
b. Factor VII
c. von Willebrand's disease
d. DIC
23. Which of the following diseases/deficiencies results in a hemolytic
anemia due to an enzyme deficiency that leads to the production of
Heinz bodies:
a. pyruvate kinase deficiency
b. paroxysmal nocturnal hemoglobinuria
c. G6PD deficiency
d. paroxysmal cold hemoglobinuria
24. Which of the following regarding hemolytic anemias is TRUE:
a. leads to jaundice
b. leads to increased indirect (unconjugated) bilirubin
c. reticulocytosis
d. all of the above
25. The following lab results were obtained on a 65 year old male in
the ER:
WBC count 3.2 x 109/L
RBC count 3.3 x 1012/dL
Hgb 10.5 gm/dL
Hct 31.1%
MCV 84 fL
MCHC 33%
Platelet 98 x 109/L
Sudan Black B - negative
Tartrate-resistant acid phosphatase - positive
Which of the following disorders is consistent with the laboratory profile:
a. aplastic anemia
b. CML
c. hairy cell leukemia
d. megaloblastic anemia
26. The following differential was obtained on a patient with a WBC
count of 15.6* 109/L:
Blasts 58%
Promyelocytes 10%
Myelocytes 5%
Metamyelocytes 4%
Bands 5%
Segs 10%
Lymphs 7%
Monocytes 1%
Is this a(an):
a. acute leukemia
b. chronic leukemia
c. Non-Hodgkin's lymphoma
d. Hodgkin's lymphoma
27. Of the following, the disease most closely associated with
granulocyte
hyposegmentation is:
a. May-Hegglin anomaly
b. Pelger-Huet anomaly
c. Chediak-Higashi syndrome
28. Which of the following is TRUE regarding fibrinolysis:
a. it is part of secondary hemostasis
b. platelets play a major role in
c. it is the removal process of fibrin
d. it involves the factor prekallikrein
29. A characteristic morphologic feature in hemoglobin C disease is:
a. spherocytosis
b. target cells
c. rouleaux formation
d. macrocytosis
30. In which of the following hereditary conditions results in large
blue granules in neutrophils:
a. May-Hegglin anomaly
b. Chediak-Higashi syndrome
c. Alder-Reilly anomaly
d. Pelger-Huet anomaly
31. In which of the following hereditary conditions results in large
blue granules in neutrophils:
a. May-Hegglin anomaly
b. Chediak-Higashi syndrome
c. Alder-Reilly anomaly
d. Pelger-Huet anomaly
32. Hemophilia B is a deficiency of factor:
a. VIII
b. XIII
c. XI
d. IX
33. Which laboratory test is used to monitor oral anticoagulant
therapy:
a. APTT (activated partial thromboplastin time)
b. PT (prothrombin time)
c. TT (thrombin time)
d. fibrinogen
34. An EDTA blood sample run on an automated impedance cell
counter has
generated a warning flag at the upper region of the platelet histogram illustrated
below. Which of the following would not be a cause of this warning flag?
A. Nucleated RBCs
B. Microcytic RBCs
C. EDTA-dependent platelet agglutinins
D. Giant platelets
35. Refer to the following illustration:
Which area in the automated cell counter histogram represents the
RBC distribution curve?
A. A
B. B
C. C
D. D
