Seat No: ______________ Enrollment No: _____________
PARUL UNIVERSITY
FACULTY OF PHARMACY
B. PHARM Summer 2022- 23 Examination
Semester: 4 Date: 19/04/2023
Subject Code: BP404T Time: 10:00am to 1:00pm
Subject Name: PHARMACOLOGY- I Total Marks: 75
Instructions:
1. Figures to the right indicate maximum marks.
2. Make suitable assumptions wherever necessary.
Q.1 Multiple Choice Questions (MCQs) (1 Mark Each) (20)
1. The following drug metabolizing reaction is entirely non- microsomal
a) Glucuronide conjugation b) Acetylation
c) Reduction d) Oxidation
2. Receptor agonists possess:
a) Affinity but no intrinsic activity b) Intrinsic activity but no affinity
c) Affinity and intrinsic activity with a + sign d) Affinity and intrinsic activity with a - sign
3. Muscarinic cholinergic receptors:
a) Are located only on parasympathetically b) Mediate responses by opening an intrinsic
innervated effector cells Na+ ion channel
c) Are present on vascular endothelium which d) Predominate in the autonomic ganglia
has no cholinergic nerve supply
4. Pilocarpine is used for:
a) Glaucoma b) paralytic ileus
c) Urinary retention d) All the above
5. Select the longer acting ocular beta blocker:
a) Timolol b) Betaxolol
c) Cartiolol d) Levobunolol
6. Which of the following drugs is a nondepolarizing neuromuscular blocker:
a) Succinylcholine b) Vecuronium
c) Dantrolene sodium d) Decamethonium
7. Local anesthetics block nerve conduction by:
a) Blocking all cation channels in the b) Hyperpolarizing the neuronal membrane
neuronal membrane
c) Interfering with depolarization of the d) Both ‘B’ and ‘C’ are correct
neuronal membrane
8. ‘Dissociative anesthesia’ is produced by:
a) Ketamine b) Fentanyl
c) Propofol d) Both ‘A’ and ‘B’ are correct
9. Hypnotic benzodiazepines increase the period of time spent in the following stage of sleep
a) Stage II b) Stage III
c) Stage IV d) REM stage
10. The drug of choice for trigeminal neuralgia is:
a) Aspirin b) Imipramine
c) Carbamazepine d) Valproic acid
11. Sodium valproate has been shown to:
a) Attenuate ‘T’ type Ca2+ current in neurons b) Inhibit degradation of GABA by GABA
transaminase
c) Prolong neuronal Na+ channel inactivation d) All the above
12. Clobazam is a benzodiazepine used as:
a) Hypnotic b) Muscle relaxant
c) Anxiolytic d) Antiepileptic
13. Drug administered through the following route is most likely to be subjected to first-pass
metabolism:
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a) Oral b) Sublingual
c) Subcutaneous d) Rectal
14. Majority of drugs cross biological membranes primarily by:
a) Passive diffusion b) Facilitated diffusion
c) Active transport d) Pinocytosis
15. An 'orphan drug' is:
a) A very cheap drug b) A drug which has no therapeutic use
c) A drug needed for treatment or prevention d) A drug which acts on Orphan in receptors
of a rare disease
16. Bioavailability of drug refers to:
a) Ratio of oral to parenteral dose b) Percentage of administered dose that reaches
systemic circulation in the unchanged form
c) Ratio of orally administered drug to that d) Ratio of drug excreted unchanged in urine to
excreted in the faces that excreted as metabolites
17. Which of the following is not true of the blood-brain barrier:
a) It is constituted by tight junctions between b) It allows passage of lipid soluble drugs into
the endothelial cells of brain capillaries and the brain
the glial tissue
c) It limits entry of highly ionized drugs into d) It regulates passage of substances from brain
the brain into blood
18. Which of the following is always true:
a) A more potent drug is more efficacious b) A more potent drug is safer
c) A more potent drug is clinically superior d) A more potent drug can produce the same
response at lower doses
19. Which of the following is true of ‘placebos’:
a) Placebo is a dummy medication b) Placebo is the inert material added to the drug
for making tablets
c) Placebos do not produce any effect d) All patients respond to placebos
20. Which of the following is a type B (unpredictable) adverse drug reaction:
a) Side effect. b) Toxic effect
c) Idiosyncrasy d) Physical dependence
Q.2 Long Answers (any 2 out of 3) {10 mark each} (20)
1. Classify parasympathomimetic. Discuss the pharmacological action, mechanism of action and
therapeutic uses of any one cholinergic drug.
2. What is bio-transporters? Explain the various phases of biotransformation reactions with suitable
examples.
3. Classify sedatives with example. Explain the mechanism of action, side effect, and therapeutic use
of diazepam.
Q.3 Short Answers (any 7 Out of 9) {5 mark each} (35)
1. Write different phases of clinical trials.
2. Write a note on drug addiction and drug habituation with examples.
3. Write a note on parenteral route of drug administration.
4. Write on the transduction mechanism in G-Protein coupled receptors.
5. Classify antiepileptic drugs. Explain different types of epilepsy
6. Discuss factors affecting of bioavailability
7. Describe pharmacological actions, therapeutic uses, and adverse effects of atropine.
8. Define general anesthesia. Write the stages of general anesthesia.
9. Write a note on centrally acting skeletal muscle relaxants.
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