0% found this document useful (0 votes)
12 views1 page

Cancer DR 48-48

Uploaded by

havadese.tarikhi
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
0% found this document useful (0 votes)
12 views1 page

Cancer DR 48-48

Uploaded by

havadese.tarikhi
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
You are on page 1/ 1

Chemical Reviews pubs.acs.

org/CR Review

(146) Zheng, G.; Zhou, D.; Zhang, X.; Wang, Y.; Chang, J. (162) Shibata, N.; Miyamoto, N.; Nagai, K.; Shimokawa, K.;
Compounds that induce degradation of anti-apoptotic bcl-2 family Sameshima, T.; Ohoka, N.; Hattori, T.; Imaeda, Y.; Nara, H.; Cho,
proteins and the uses thereof. WO2017184995A1, 2017. N.; et al. Development of Protein Degradation Inducers of Oncogenic
(147) Quintas-Cardama, A.; Cortes, J. Molecular Biology of Bcr- BCR-ABL Protein by Conjugation of ABL Kinase Inhibitors and IAP
Abl1-Positive Chronic Myeloid Leukemia. Blood 2009, 113, 1619− Ligands. Cancer Sci. 2017, 108, 1657−1666.
1630. (163) Lai, A. C.; Toure, M.; Hellerschmied, D.; Salami, J.; Jaime-
(148) Manley, P. W.; Cowan-Jacob, S. W.; Buchdunger, E.; Fabbro, Figueroa, S.; Ko, E.; Hines, J.; Crews, C. M. Modular PROTAC
D.; Fendrich, G.; Furet, P.; Meyer, T.; Zimmermann, J. Imatinib: A Design for the Degradation of Oncogenic BCR-ABL. Angew. Chem.,
Selective Tyrosine Kinase Inhibitor. Eur. J. Cancer 2002, 38, S19−S28. Int. Ed. 2016, 55, 807−810.
(149) Apperley, J. F. Mechanisms of Resistance to Imatinib in (164) Burslem, G. M.; Schultz, A. R.; Bondeson, D. P.; Eide, C. A.;
Chronic Myeloid Leukaemia. Lancet Oncol. 2007, 8, 1018−1029. Savage Stevens, S. L.; Druker, B. J.; Crews, C. M. Cancer Res. 2019,
(150) Soverini, S.; Colarossi, S.; Gnani, A.; Rosti, G.; Castagnetti, F.; 79, 4744−4753.
Poerio, A.; Iacobucci, I.; Amabile, M.; Abruzzese, E.; Orlandi, E.; et al. (165) Chapman, P. B.; Hauschild, A.; Robert, C.; Haanen, J. B.;
Contribution of ABL Kinase Domain Mutations to Imatinib Ascierto, P.; Larkin, J.; Dummer, R.; Garbe, C.; Testori, A.; Maio, M.;
Resistance in Different Subsets of Philadelphia-Positive Patients: By et al. Improved Survival with Vemurafenib in Melanoma with BRAF
the GIMEMA Working Party on Chronic Myeloid Leukemia. Clin. V600E Mutation. N. Engl. J. Med. 2011, 364, 2507−2516.
Cancer Res. 2006, 12 (24), 7374−7379. (166) Yang, H.; Higgins, B.; Kolinsky, K.; Packman, K.; Go, Z.; Iyer,
(151) Blair, J. A.; Rauh, D.; Kung, C.; Yun, C.-H.; Fan, Q.-W.; Rode, R.; Kolis, S.; Zhao, S.; Lee, R.; Grippo, J. F.; et al. RG7204
H.; Zhang, C.; Eck, M. J.; Weiss, W. A.; Shokat, K. M. Structure- (PLX4032), a Selective BRAFV600E Inhibitor, Displays Potent
Guided Development of Affinity Probes for Tyrosine Kinases Using Antitumor Activity in Preclinical Melanoma Models. Cancer Res.
Chemical Genetics. Nat. Chem. Biol. 2007, 3, 229−238. 2010, 70, 5518−5527.
(152) Blay, J. Y.; von Mehren, M. Nilotinib: A Novel, Selective (167) Tsai, J.; Lee, J. T.; Wang, W.; Zhang, J.; Cho, H.; Mamo, S.;
Tyrosine Kinase Inhibitor. Semin. Oncol. 2011, 38, S3−S9. Bremer, R.; Gillette, S.; Kong, J.; Haass, N. K.; et al. Discovery of a
(153) Das, J.; Chen, P.; Norris, D.; Padmanabha, R.; Lin, J.; Moquin, Selective Inhibitor of Oncogenic B-Raf Kinase with Potent
R. V.; Shen, Z.; Cook, L. S.; Doweyko, A. M.; Pitt, S.; et al. 2- Antimelanoma Activity. Proc. Natl. Acad. Sci. U. S. A. 2008, 105,
Aminothiazole as a Novel Kinase Inhibitor Template. Structure- 3041−3046.
Activity Relationship Studies toward the Discovery of N-(2-Chloro-6- (168) Nazarian, R.; Shi, H.; Wang, Q.; Kong, X.; Koya, R. C.; Lee,
methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl)]-2-methyl-4- H.; Chen, Z.; Lee, M.-K.; Attar, N.; Sazegar, H.; et al. Melanomas
pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide (Dasatinib, BMS- Acquire Resistance to B-RAF(V600E) Inhibition by RTK or N-RAS
354825) as a Potent pan-Src Kinase Inhibitor. J. Med. Chem. 2006, Upregulation. Nature 2010, 468, 973−977.
49, 6819−6832. (169) Van Allen, E. M.; Wagle, N.; Sucker, A.; Treacy, D. J.;
(154) Golas, J. M.; Arndt, K.; Etienne, C.; Lucas, J.; Nardin, D.; Johannessen, C. M.; Goetz, E. M.; Place, C. S.; Taylor-Weiner, A.;
Whittaker, S.; Kryukov, G. V.; et al. The Genetic Landscape of
Gibbons, J.; Frost, P.; Ye, F.; Boschelli, D. H.; Boschelli, F. SKI-606, a
Clinical Resistance to RAF Inhibition in Metastatic Melanoma. Cancer
4-Anilino-3-quinolinecarbonitrile Dual Inhibitor of Src and Abl
Discovery 2014, 4, 94−109.
Kinases, Is a Potent Antiproliferative Agent against Chronic
(170) Arozarena, I.; Wellbrock, C. Overcoming Resistance to BRAF
Myelogenous Leukemia Cells in Culture and Causes Regression of
Inhibitors. Ann. Transl. Med. 2017, 5, 387−399.
K562 Xenografts in Nude Mice. Cancer Res. 2003, 63, 375−381.
(171) Griffin, M.; Scotto, D.; Josephs, D. H.; Mele, S.; Crescioli, S.;
(155) Huang, W. S.; Metcalf, C. A.; Sundaramoorthi, R.; Wang, Y.;
Bax, H. J.; Pellizzari, G.; Wynne, M. D.; Nakamura, M.; Hoffmann, R.
Zou, D.; Thomas, R. M.; Zhu, X.; Cai, L.; Wen, D.; Liu, S.; et al. M.; et al. BRAF Inhibitors: Resistance and the Promise of
Discovery of 3-[2-(imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methyl- Combination Treatments for Melanoma. Oncotarget 2017, 8,
N-{4-[(4-methylpiperazin-1-y l)methyl]-3-(trifluoromethyl)phenyl}- 78174−78192.
benzamide (AP24534), a Potent, Orally Active Pan-Inhibitor of (172) Kirouac, D. C.; Schaefer, G.; Chan, J.; Merchant, M.; Orr, C.;
Breakpoint Cluster Region-Abelson (BCR-ABL) Kinase Including the Huang, S. A.; Moffat, J.; Liu, L.; Gadkar, K.; Ramanujan, S. Clinical
T315I Gatekeeper Mutant. J. Med. Chem. 2010, 53, 4701−4719. Responses to ERK Inhibition in BRAF(V600E)-Mutant Colorectal
(156) Adrian, F. J.; Ding, Q.; Sim, T.; Velentza, A.; Sloan, C.; Liu, Cancer Predicted Using a Computational Model. npj Syst. Biol. Appl.
Y.; Zhang, G.; Hur, W.; Ding, S.; Manley, P.; et al. Allosteric 2017, 3, 14.
Inhibitors of Bcr-Abl-Dependent Cell Proliferation. Nat. Chem. Biol. (173) Yao, Z.; Gao, Y.; Su, W.; Yaeger, R.; Tao, J.; Na, N.; Zhang, Y.;
2006, 2, 95−102. Zhang, C.; Rymar, A.; Tao, A.; et al. RAF Inhibitor PLX8394
(157) Wylie, A. A.; Schoepfer, J.; Jahnke, W.; Cowan-Jacob, S. W.; Selectively Disrupts BRAF Dimers and RAS-Independent BRAF-
Loo, A.; Furet, P.; Marzinzik, A. L.; Pelle, X.; Donovan, J.; Zhu, W.; Mutant-Driven Signaling. Nat. Med. 2019, 25, 284−291.
et al. The Allosteric Inhibitor ABL001 Enables Dual Targeting of (174) Byrd, J. C.; Furman, R. R.; Coutre, S. E.; Flinn, I. W.; Burger,
BCR-ABL1. Nature 2017, 543, 733−737. J. A.; Blum, K. A.; Grant, B.; Sharman, J. P.; Coleman, M.; Wierda, W.
(158) Zhang, J.; Adrian, F. J.; Jahnke, W.; Cowan-Jacob, S. W.; Li, A. G.; et al. Targeting BTK with Ibrutinib in Relapsed Chronic
G.; Iacob, R. E.; Sim, T.; Powers, J.; Dierks, C.; Sun, F.; et al. Lymphocytic Leukemia. N. Engl. J. Med. 2013, 369, 32−42.
Targeting Bcr-Abl by Combining Allosteric with ATP-Binding-Site (175) Pan, Z.; Scheerens, H.; Li, S. J.; Schultz, B. E.; Sprengeler, P.
Inhibitors. Nature 2010, 463, 501−506. A.; Burrill, L. C.; Mendonca, R. V.; Sweeney, M. D.; Scott, K. C.;
(159) Fabbro, D.; Manley, P. W.; Jahnke, W.; Liebetanz, J.; Grothaus, P. G.; et al. Discovery of Selective Irreversible Inhibitors for
Szyttenholm, A.; Fendrich, G.; Strauss, A.; Zhang, J.; Gray, N. S.; Bruton’s Tyrosine Kinase. ChemMedChem 2007, 2, 58−61.
Adrian, F.; et al. Inhibitors of the Abl Kinase Directed at Either the (176) Bender, A. T.; Gardberg, A.; Pereira, A.; Johnson, T.; Wu, Y.;
ATP- or Myristate-Binding Site. Biochim. Biophys. Acta, Proteins Grenningloh, R.; Head, J.; Morandi, F.; Haselmayer, P.; Liu-Bujalski,
Proteomics 2010, 1804, 454−462. L. Ability of Bruton’s Tyrosine Kinase Inhibitors to Sequester Y551
(160) Schoepfer, J.; Jahnke, W.; Berellini, G.; Buonamici, S.; Cotesta, and Prevent Phosphorylation Determines Potency for Inhibition of Fc
S.; Cowan-Jacob, S. W.; Dodd, S.; Drueckes, P.; Fabbro, D.; Gabriel, Receptor but not B-Cell Receptor Signaling. Mol. Pharmacol. 2017,
T.; et al. Discovery of Asciminib (ABL001), an Allosteric Inhibitor of 91, 208−219.
the Tyrosine Kinase Activity of BCR-ABL1. J. Med. Chem. 2018, 61, (177) Honigberg, L. A.; Smith, A. M.; Sirisawad, M.; Verner, E.;
8120−8135. Loury, D.; Chang, B.; Li, S.; Pan, Z.; Thamm, D. H.; Miller, R. A.;
(161) Nussinov, R.; Tsai, C. J. Allostery in Disease and in Drug et al. The Bruton Tyrosine Kinase Inhibitor PCI-32765 Blocks B-Cell
Discovery. Cell 2013, 153, 293−305. Activation and is Efficacious in Models of Autoimmune Disease and

AV https://dx.doi.org/10.1021/acs.chemrev.0c00383
Chem. Rev. XXXX, XXX, XXX−XXX

You might also like