Pharmacology

MCQs
PROFESSOR G N PUROHIT
1. Assertion (A): Drugs administered by the intravenous (IV)
route provide 100% bioavailability.
Reason (R): IV administration bypasses the first-pass effect.
a) Both A and R are true, and R is the correct explanation for A.
b) Both A and R are true, but R is not the correct explanation
for A.
c) A is true, but R is false.
d) A is false, but R is true.
2. Assertion (A): Oral drug administration is unsuitable for
emergencies.
Reason (R): Oral drugs have a slower onset of action due to the
absorption process.
a) Both A and R are true, and R is the correct explanation for A.
b) Both A and R are true, but R is not the correct explanation
for A.
c) A is true, but R is false.
d) A is false, but R is true.
3. Assertion (A): Subcutaneous administration is unsuitable for
irritant drugs.
Reason (R): Subcutaneous tissue is richly supplied with nerves
but less vascularised.
a) Both A and R are true, and R is the correct explanation for A.
b) Both A and R are true, but R is not the correct explanation
for A.
c) A is true, but R is false.
d) A is false, but R is true.
4. Match the drug administration routes with their characteristics:
Route Characteristic
A. Intravenous (IV) 1. Depot preparation
B. Intramuscular 2. Rapid onset, emergency use
C. Oral 3. Avoids first-pass metabolism
D. Sublingual 4. Risk of aspiratory pneumonia
a) A-2, B-1, C-4, D-3
b) A-3, B-2, C-1, D-4
c) A-4, B-3, C-2, D-1
d) A-1, B-4, C-3, D-2
5. Match the following routes with their examples:
Route Example
A. Topical 1. Intraocular drops
B. Parenteral 2. Subcutaneous injection
C. Specialized 3. Transdermal patch
D. Local 4. Dusting powder
a) A-3, B-2, C-1, D-4
b) A-4, B-3, C-2, D-1
c) A-1, B-2, C-3, D-4
d) A-4, B-2, C-3, D-1
6. Statement I: Liposomes are used for targeted drug delivery.
Statement II: Liposomes can transport both lipophilic and
hydrophilic drugs.
a) Both statements are true.
b) Both statements are false.
c) Statement I is true, and Statement II is false.
d) Statement I is false, and Statement II is true.
7. Statement I: Drugs administered through the intramuscular
route have a longer duration than IV drugs.
Statement II: The intramuscular route is unsuitable for oily
suspensions.
a) Both statements are true.
b) Both statements are false.
c) Statement I is true, and Statement II is false.
d) Statement I is false, and Statement II is true.
8. Which of the following is incorrect about IV drug
administration?
a) Quick onset of action
b) Requires sterile preparation
c) Suitable for depot preparations
d) Provides 100% bioavailability
9. Which of the following is incorrect about oral drug
administration?
a) Suitable for large liquid volumes
b) Unpredictable absorption
c) Avoids first-pass effect
d) Risk of superinfection with antibiotics
10. What is the preferred site for epidural injections in cattle?
a) Between 2nd and 3rd coccygeal vertebrae
b) Between 1st and 2nd coccygeal vertebrae
c) Between lumbar vertebrae
d) Between thoracic vertebrae
11. Which of the following is NOT an advantage of transdermal
drug delivery systems (TDS)?
a) Bypasses first-pass metabolism
b) Allows rapid onset of action
c) Useful for drugs with narrow therapeutic indices
d) Provides controlled drug release
12. Assertion (A): Drugs administered via sublingual route bypass
the first-pass effect.
Reason (R): The sublingual route involves absorption through the
buccal mucosa, which directly enters systemic circulation.
a) Both A and R are true, and R is the correct explanation for A.
b) Both A and R are true, but R is not the correct explanation for A.
c) A is true, but R is false.
d) A is false, but R is true.
13. Assertion (A): Intramuscular administration is ideal for highly
viscous drug preparations.
Reason (R): Skeletal muscles are richly supplied with blood vessels
but less sensitive to irritation.
a) Both A and R are true, and R is the correct explanation for A.
b) Both A and R are true, but R is not the correct explanation for A.
c) A is true, but R is false.
d) A is false, but R is true.
14. Match the following parenteral routes with their key features:
Route Key Feature
A. Intravenous 1. Rich in nerve supply
B. Subcutaneous 2. Large absorption surface area
C. Intraperitoneal 3. Risk of puncturing organs
D. Intramuscular 4. Depot preparation suitable
a) A-2, B-1, C-3, D-4
b) A-3, B-2, C-1, D-4
c) A-1, B-3, C-4, D-2
d) A-4, B-1, C-3, D-2
15. Match the following routes with their associated advantages:
Route Advantage
A. Inhalation 1. Controlled drug release
B. Transdermal 2. Avoids hepatic first-pass effect
C. Topical 3. Minimal systemic side effects
D. Oral 4. Safe and convenient
a) A-2, B-1, C-4, D-3
b) A-1, B-2, C-3, D-4
c) A-4, B-2, C-3, D-1
d) A-2, B-4, C-3, D-1
16. Statement I: Oral drug administration is suitable for drugs with
extensive hepatic metabolism.
Statement II: Drugs that undergo the first-pass effect are
metabolized before reaching systemic circulation.
a) Both statements are true.
b) Both statements are false.
c) Statement I is true, and Statement II is false.
d) Statement I is false, and Statement II is true.
17. Statement I: Epidural administration avoids puncturing the
meninges.
Statement II: Epidural drugs are deposited into the subarachnoid
space.
a) Both statements are true.
b) Both statements are false.
c) Statement I is true, and Statement II is false.
d) Statement I is false, and Statement II is true.
18. Which of the following is incorrect about the inhalation route?
a) It provides rapid onset for volatile drugs.
b) Requires special devices like nebulizers.
c) Ideal for large domestic animals.
d) Suitable for respiratory tract diseases.
19. Which of the following is incorrect about topical drug
application?
a) Inunction involves rubbing ointments on the skin.
b) Sublingual drugs are applied on skin for absorption.
c) Dusting involves fine powder application.
d) Transdermal patches release drugs into systemic circulation.
20. Which of the following is a key disadvantage of the
intraperitoneal (IP) route?
a) Large surface area for absorption.
b) Risk of chemical peritonitis.
c) Suitable for small-sized animals.
d) Allows administration of large volumes.
21. Which route allows for moment-to-moment adjustment of drug
effects?
a) Oral
b) IV
c) Inhalation
d) Subcutaneous
22. Which of the following drugs are least absorbed via oral
administration?
a) Lipophilic drugs
b) Highly polar drugs
c) Weak acids
d) Weak bases
23. What is a specialized device for needleless drug administration?
a) Dermojet
b) Liposome
c) Nebulizer
d) Transdermal patch
24. Which site is commonly used for subcutaneous injections in
horses?
a) Inner aspect of the thigh
b) Gluteal muscle
c) Middle third of the neck
d) Cephalic vein
25. Which of the following is NOT an advantage of the
intramuscular (IM) route?
a) Depot preparation suitability
b) Precise control of drug effects
c) Mild irritants can be administered
d) Suitable for wild animals
26. Assertion (A): The inhalation route is suitable for delivering
non-volatile substances.
Reason (R): Non-volatile substances remain largely unabsorbed
and produce local effects on bronchiolar smooth muscles.
a) Both A and R are true, and R is the correct explanation for A.
b) Both A and R are true, but R is not the correct explanation for A.
c) A is true, but R is false.
d) A is false, but R is true.
27. Match the following specialized routes with their primary use:
RouteUse
A. Intrathecal 1. Drug delivery into bone marrow
B. Intra-articular 2. Joint diseases
C. Intra-medullary 3. Subarachnoid space
D. Intra-uterine 4. Uterine infections
a) A-3, B-2, C-1, D-4
b) A-4, B-3, C-2, D-1
c) A-2, B-1, C-4, D-3
d) A-1, B-4, C-3, D-2
28. Statement I: Parenteral administration is preferred in animals
that are uncooperative or vomiting.
Statement II: Oral administration is effective for emergency drug
delivery.
a) Both statements are true.
b) Both statements are false.
c) Statement I is true, and Statement II is false.
d) Statement I is false, and Statement II is true.
29. Which of the following is incorrect about topical drug
administration?
a) Drugs with high lipid solubility are absorbed through the skin.
b) Topical drugs have no risk of systemic absorption.
c) Transdermal patches provide controlled systemic delivery.
d) Topical drugs can be applied as dusting powders.
30. Which of the following is NOT an advantage of oral drug
administration?
a) Safe and convenient.
b) Suitable for gastrointestinal infections.
c) Predictable absorption of all drugs.
d) Large volumes of liquid can be administered.
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