INTRODUCTION
Antacids are chemical substances which neutralizing the acid that
cause heartburn. By reducing the acidity, the acid is less able to
irritate the esophagus. The effect of antacids on stomach Is due to
partial neutralisation of gastric Hel acid and inhibiting of the
proteolytic enzyme pepsine. There are commonly used self-
prescribed medications. Antacids are available many form such as
suspensions, chewable tablet and liquid gels. They consist of calcium
carbonate and aluminium and magnesium salts in various compound
or combinations. Antacids are used for gastric and duodenal ulcers,
gastro- oesophageal flux, reflux disease, stress gastritis, pancreatic
sufficiency, non ulcer dyspepsia, bile acid mediated diarrhea,
constipation, osteoporosis, urinary alkalinastion and chronic renal
failure as a dietary phosphate hinder. Acid neutralizing capacity and
hyper acidity.
introduction: These are drugs which are usually substances and used
for neutralizing excess acid in the stomach of patients suffering from
hyper-chlorhydria (hyperacidity). The drugs give symptomatic relief
of pain due to hyper-chlorhydria (1) Antacids substances which
reduce gastric acidity resulting in an increase in the pH of the
stomach and duodenum. Gastric acidity occurs due to excessive
secretion of HCL in the stomach due to various reasons (2) Gastritis
(A) general.
ACKNOWLEDGEMENT
I feel proud to present my investigatory project in chemistry
on the topic comparative study of antacids.
This project would not have been feasible without the proper
rigorous guidance of my chemistry teacher Mr SK Pradhan sir
for guiding me on step by step basic and ensuring that I
complete my experiment with ease. Rigorous hard work has
been putting this project to ensure that it proves to be the
best. I hope that this project will proves be breeding ground
for the next generation of student and will guide them in
every possible ways.
I would take this opportunity to express my cordial sense of
gratitude to our Principal Mr. Roopendra Singh Thakur Sir for
his fruitful suggestion guidance and providing laboratory
facilities to us to carry out all the experiment with this
project involve to.
4. Standardize the HCl solution by the titrating it against the
standard Na2CO3 solution using ethyl Orange as indicator
Similarity standardised NaOH solution by titrating it against
standardised HCl solution using phenolphthalein as indicator.
5. Powder the various sample of antacid tablet and weight
them 1gm each.
6. Add a specific volume of standardize HCI to each of the
weighted sample taken conical flask. The acids should be in
slide excess, so that it can neutralize all the alkaline
component of tablet.
7. Add to drop of phenolphthalene and warm the flask till
most of the powder dissolve. Filter off the insoluble material.
8. Titrate the solution against standardised NaOH solution, till
a permanent pinkish colour is obtain. Repeat this experiment
with different antacids.
Antacid were the only useful drug available for this condition.
Most commercially available antacids are combination of
aluminium and magnesium hydroxide. Some effervescent
antacid contain sodium bicarbonate, that old household
remedy for tummy aches known as "baking soda". Some
antacids are combined with alginate (an insoluble substance
that increase surface tension in liquid) to o form a compound
that float on gastric fluid to protect the oesophagus from acid
exposure, Antacid tablets are slow acting and have less
neutralizing power than the equivalent liquid preparation.
Tablet must achieved and may not interact well with gastric
acid.
Inflammation of gastric mucosa) Peptic ulcer oesophagus
ulcer (lower end of oesophagus) Duodenom ulcer-gastric
ulcer(stomach). Antacid do not decrease acid production. If
antacids are water soluble they may be able to produce
systematic alkalosis due to that of absorbable ions disturbing
acid-huse balance of body fluids. Except sodium bicarbonate,
most of antacids are water soluble. Antacid act on
gastrointestinal tract after being converted into soluble salt
by HCI(1) The potency of an antacid is generally express in
the term of its acid utilising capacity(ANC). ANC is defined as
number of m Eq of 1N HCI that are brought to P11 3.5 in 15
minutes (or 60 minute in some test) by a unit does of antacid.
(2) Antacids are the oldest effective medication for peptic
ulcers and heartburn.Chalk (calcium carbonate) has been
chewed for centuries to is this peptic and steel popular.
Indeed, before the arrival of first H2 enter antagonist in 1970.
Standardization of NaOH solution
Volume of the given NaOH solution taken 20 mL
SERIAL NO. BURETTE BURETTE VOLTMEDI
READING READING ACID USED
INITIALLY FINAL
1.
2.
3.
Concordant reading:
Applying Normality formula:
NIV1-N2V2
OBSERVATION AND CALCULATIONS
Standardisation Of HCI Solution: Volume of N/10
Na2003 solution taken-20ml
SERIAL NO. BURETTE BURETTE VOLTMEDI
READING READING ACID USED
INITIALLY FINAL
1.
2.
3.
● Concordent Reading:
● Applying Normality Equation :
N1V1=N2V2
ACID = BASE
● N1 x ……. = 1/10 x 20
● Normality of HCl , N1 =
2/………=..........N
CERTIFICATE
This is to certify that roll
no. is a student of class 12th PM Shri
Jawahar Navodaya Vidyalaya Dongargarh
successfully completed her investigatory project
of chemistry on the topic comparative study of
antacids as per syllabus of class 12th board
examination conducted by CBSE under my
guidance.
PRINCIPAL PRINCIPAL
MR.ROOPENDRA SINGH SIR
SUBJECT TEACHER:
S.K.PRADHAN SIR
EXTERNAL:
Experiment
OBJECTIVE:-This project aim at analysing some of the
commercial antacid to determined how much HCl ( of given
normality) they can neutralize.
AIM:- To analyse the given samples of commercial antacid by
determining the amount of HCl they can neutralize.
REQUIREMENTS:-Burette,puppets,titration flask ,beaker,
weight box,fractional weights, sodium hydroxide
(NaOH),sodium carbonate (Na2CO3) HCI, phenolphthalein.
PROCEDURE :-
1. Prepare one litre of approximately N/10 HCI solution by
leading 10 ml of concentrated acid to one litre.
2. Similarly make a 1 Lof approximately N/10 NaOH solution
by dissolving 4 gram of NaOH to prepare 1L of solution.
3. Prepare N/10 and Na2CO3 solution weighing exactly 1.325
gram of anhydrous sodium carbonate and then dissolving it
in water to prepare exactly 0.25 L or 250 ml of solution..
