Week 13
Week 13
- An English mathematician
                     Printing Press                                  - Hired in 1936 by the British top-secret Government
  •   Was invented by German goldsmith Johannes                          Code and Cipher School at Bletchley Park to break
      Gutenberg around 1440                                              the Enigma Code
  •   A device that applies pressure to an inked surface lying       - Code-breaking works became an industrial process
      on a medium, i.e., cloth or paper to transfer the ink              having 12,000 people working three shifts day in and
  •   Hand mould printing press led to the creation of metal             day out, 24/7
      movable type                                               •   Nazis had made the Enigma machines more
  •   A new branch of media was known as “the press”                 complicated having approximately 10^114 possible
  •   Era of mass communication                                      permutations
  •   Permanently reformed the structure of society              •   Turing designed Bombe
      - Political and religious authorities were threatened          - An electromechanical machine
          due to the increase of literate population                 - Made British able to read all daily German Naval
      - Middle class was distinguished                                   Enigma traffic by searching through the
      - Protonationalism had grown due to rapid increase of              permutations
          vernacular languages                                       - Saved millions of lives since the invention shortened
  •   Rotary press run by steam and used in industrial scale             the war by as much as two years
      printing in 19th century                                   •   Published paper entitled “On Computable Numbers,
                Computer Development                                 with an application to the Entscheidungsproblem,” in
  •   Communications needed calculations due to advancing            1936
      trade and industry                                             - Presented a theoretical machine, called the Turing
  •   Computers were people who complied actuarial tables                Machine
      and did engineering calculations                               - Turing machine= solve any problem from simple
                                                                         instructions encoded on a paper tape
  •   During World War II, the Allies, countries that opposed
      the Axis powers (Germany, Japan, and Italy), had           •   Demonstrated simulation of Turing machine to construct
      shortage of human computers for military calculations          a single Universal Machine
                                                                     - Became the foundation of computer science and the
  •   United States mechanized the problem by building the
                                                                         invention of a machine that can solve any problem
      Harvard Mark 1
                                                                         by performing any task from a written program later
      - An electromechanical monster 50 feet long
                                                                         called Computer
      - Capable of doing calculations in seconds
                                                                 •   A generation with “electronic brains” was born by the
  •   British needed mathematicians to crack the German
                                                                     1970s who wanted their own personal computers (PCs).
      Navy’s Enigma Code
      - Used by Germans to transcribe their messages in          •   In 1975, members of the Homebrew Computer Club,
           encryption using a machine called Enigma                  became eager with the potential of the new silicon chips
           Enigma- looked like an oversized typewriter               - Allow them to build their own computers
   •   Steve Wozniak built a simple computer around the 8080                  Impacts of the Information Age
       microprocessor hooked up to a keyboard and television        •   Development of the information age from the
       in 1976                                                          discovery of printing press to the creation of social
   •   Steve Jobs called the computer Apple I and sold                  media platforms have impacted our lives
       replicates of this machine to a Silicon Valley shop              individually and the society as a whole.
   •   Bill Gates realized that PCs needed software and sold
                                                                    •   The impacts may be beneficial or adverse
       his Microsoft programs
                                                                        depending on how these discoveries were used.
                 Social Media Creations
  From 1973 onwards different social media creations were        Week 14: Biodiversity and the Healthy Society
introduced:                                                                                Biodiversity
    • Multi-user chat rooms                                         •   the variety present in all forms of life.
    • Instant-messaging, e.g., AOL, Yahoo Messenger, MSN            •   3 types of Biodiversity
       Messenger, Windows Messenger                                     1. Genetic Biodiversity
    • Conferencing and bulletin-board forum system                           -variation of genes within the species that gives
    • Exchanging e-mails                                                     distinction of one population from another even of
    • Game-based social networking websites, i.e.,                           the same species.
       Friendster, Myspace, Facebook, Twitter, VK, Tumblr               2. Species diversity
    • Business-oriented social networking websites, i.e., Xing               -variety of species within a particular region
                                                                             -similar species are grouped together in families,
    • Messaging, video and voice calling service, e.g., Skype
                                                                        families in orders up to kingdom
    • blogging platform, image and video hosting website,
                                                                        3. Ecological Diversity
       e.g., Flicker
                                                                            -the number of species in a community of organisms
    • discovery and dating-oriented website, e.g., Tagged,
                                                                            -variations of climatic and altitudinal conditions and
       Tinder
                                                                        ecological habitats
    • video-sharing service allowing users to post virtually
                                                                                Biodiversity and the Society
       everything, e.g., YouTube
                                                                 Society benefits a lot from the richness of biodiversity
    • real-time social media feed aggregator, e.g., FriendFeed   Goods and services from the natural systems
    • live-streaming, e.g., Justin.tv, Twitch.tv                    • Foods, energy, timber and pharmaceutical products
    • photo-video sharing website, e.g., Pinterest, Instagram,      • Regulation of climate, water storage, flood control,
       Snapchat, Keek, Vine                                             buffering against extreme weather events, treatment of
    • question-and-answer platform, e.g., Quora                         water and air, regeneration of soil fertility, decomposition
   To date, these social-media platforms were just bought by            of wastes.
one company owner to another and were modified based on the                          Health and Medicine
dynamic needs of the users.
                                                                    •   2600 B.C., natural products, i.e., Cupressus
                                                                        sempervirens (Cypress) and Commiphora species
                                                                        (myrrh) for coughs, colds and inflammation
•   Healing rituals and treatments of injuries resulted        •   10th century to 1700s: active constituent digitoxin
    from wars or accidents                                         derived from Digitals purpurea (foxglove) in Europe and
•   Over 700 plant-based drugs ranging from gargles, pills,        used in congestive heart failure
    infusions, to ointments were used by Egyptians             •   1942 to 1944: penicillin
•   Chinese in 1100 B.C. up to 659 A.D. utilized from 365 up       - antibiotic used to treat infections caused by
    to as high as 850 drugs from natural products                  susceptible bacteria
•   In 100 A.D., Greeks recorded the collection, storage       •   1970s: the production of bacterial strains
    and the uses of medicinal herbs up to 300 B.C.                 supersensitive β-lactams, tests for the inhibition of β-
•   During the Dark and Middle Age, the monasteries in             lactams and specificity for sulphur-containing
    England, Ireland, France, and Germany preserved this           metabolites
    Western knowledge on treating illnesses.                       - novel antibiotic structural classes, i.e., noncardicins,
•   Arabs preserved the Greco-Roman practice and                   carbapenems and monobactams
    expanded the uses of their own resources, and mixed            - isolation of the antibiotics, norcardicin, imipenem,
    with Chinese and Indian herbs                                  and aztreonam
•   Plant genus Salvia apiana used by Indian tribes of             - 25,000 species of basidiomycetes and Ascomycota:
    Southern California as an aid in childbirth and it gives       antiviral, cytotoxic, antineoplastic, cardiovascular, anti-
    high immune from all respiratory ailments.                     inflammatory, immune stimulating and anticancer
    - Secretes a sweet, gummy material from the stems and          activities
    leaves called “manna” during hot days                          - Fungi, microorganisms found in trees, grasses, algae,
    - contains melezitose, sucrose and invert sugar and            and herbaceous plants and live in the intercellular
    claimed to treat anorexia, constipation, dermatosis,           spaces of plant stems, petioles, roots, and leaves
    epistaxis, fever, leprosy, and obesity                     •   1994: oral formulation of pilocarpine for dry mouth
•   Israelis also took the extract from roots for diarrhea         (xerostomia)
•   The Konkani people smoked the plant for the treatment      •   1998: an autoimmune disease that damages the
    of asthma                                                      salivary and lacrimal glands called Sjogren’s Syndrome
•   Romans used the plant for nasal polyps                     •   2004: drug quinine was isolated from the bark of
•   Plant Ligusticum scoticum Linnaeus                             Cinchona succirubra Pav. Ex Klotsch to treat malaria
    - protect a person from infection                                                    Food
    - the root was a cure for flatulence, an aphrodisiac and   •   Hunting and foraging what’s available in their habitat,
    was used as a sedative in the Faeroe Islands                   fishing was also done
•   Anti-inflammatory agent, acetylsalicyclic acid known       •   cultivation started 12,000 years ago
    as aspirin                                                 •   domestication of animals a thousand years after
•   1870s: crude morphine from the plant Papaver               •   agriculture and cultivation of plants for food
    comniferum, used as painkiller                             •   cultivate desired species of crops and animals
                                                                   suitable for consumption
                                                               •   prevention of diseases that could affect food supply
•   invention of different ways to cook and prepare meals         - Ancient Chinese for water pumps
•   more hunting, fishing and even more lands to be used in       - Middle Eastern civilizations for grinding crops
    agriculture                                               •   In 1600s, coal and the British discovered that cooking
•   healthy ecosystems to provide foods daily for our             coal transforms it into hot-burning coke
    consumption
•   Biodiversity is necessary for most of our important       •   In 1700s, coal began to replace other energy sources
    crops, though most of them are wind-pollinated, about         became the primary source of energy around the
    39 of the                                                     world.
    leading 57 global crops need birds and insects as         •   In 1820s, natural gas was used as a source of light
    pollinators.                                              •   In 1830s, the electric generator, motor and relay were
•   Agrobiodiversity is the biodiversity resulted from            developed based on Michael Faraday’s discovery of
    planned agricultural crops or livestock.                      electromagnetism
    - i.e., genetic biodiversity of varieties of organisms    •   In 1850s, commercial oil was drilled and led to
    - farmers planning result to resistance to disease,           distillation of kerosene from petroleum
    tolerance to extreme climate conditions                   •   In 1860s, Augustine Mouchot developed the first solar
    - important for food security in the event of flood,          powered system for industrial machinery
    drought or infestation of pests                           •   In 1892, the first utilization of geothermal heat to power
                       Energy                                     was done.
•   Heat energy from fire for survival against cold harsh     •   In 1942, the first nuclear fission reactor was designed
    environment, for cooking, and for communication in            and built.
    the form of smoke in 770,000 BC.                          •   In the 19th century and 20th century, the utilization of
•   In 1000 BC, coal: northeastern China for heating and          coal energy
    cooking purposes                                              - led to shaping up the industrial era of developing
    - Romans and Northern Native Americans                        countries
•   In 400 BC, water energy or hydro power was used for       •   No direct effect on biodiversity yet
    powering machineries and for irrigation by the            •   As early as 1973, the effects on the environment and
    Ancient Greeks and Romans.                                    the risk of potential accidents alarmed many
•   In 347 AD, China: oil wells using extensive bamboo            environmental organizations
    pipelines with depths 800 feet for lighting and heating   •   In 1979, a nuclear reactor accident at Three Mile
•   In 1000: Persian: first windmills to pump water and           Island near Middletown, Pennsylvania happened.
    grind grain                                               •   At the end of 1980, the Exxon Valdez disaster in Alaska
•   By 1300, windmills began to form the modern pinwheel          became the biggest oil spill in U.S. waters.
    shape in Western Europe                                   •   In 2000s, a number of catastrophic events transpired,
•   1390s, the Dutch: most efficient version of the               e.g.,
    windmill                                                      - climate change
    - for navigation through bodies of water                      - coal ash spill in Tennessee
    - oil spill in the Gulf of Mexico                                 percolation occurs running surface water into rivers
    - Fukushima nuclear crisis in Japan                               and lakes.
•   A study conducted by Nathan Jones (2012) shows that           •   Forests play major role in hydrological cycle by
    biodiversity has been affected by the usage of                    affecting rates of transpiration and evaporation and
    different forms of energy, primarily the fossil fuels.            water storage in watersheds.
    The effects include:                                          •   Flooding provides critical habitat for fish, waterfowl,
    1. wildlife mortality                                             and wildlife, and helps maintain high levels of plant and
    2. habitat loss                                                   animal diversity.
    3. fragmentation                                              •   Floodwaters also replenish agricultural soils with
    4. noise and light pollution                                      nutrients and transport sediment that is necessary to
    5. invasive species                                               maintain downstream delta and coastal areas.
    6. changes in carbon stock                                        - production of new plant and animal tissue
    7. water resources                                                - plants colonize new areas or take advantage of the
         Water Storage and Flood Control                              increased light that becomes available when old
•   Earliest recorded civilization was situated near bodies           vegetation is cleared away
    of rivers or lakes, which marks as the earliest record of         - animals such as invertebrates and fish often find new
    water consumption.                                                food sources
•   With increasing demand for potable and drinkable water,           - major floods in coastal plain areas in southeastern US
    wells began to be used 2,000 years ago, in Middle East            in 1994 and in the forested mountains in Pacific
    (Israel) from discovery of groundwater dug from sands             Northwest in 1996
    or rocks as well collection of rainwater.                             -create a much more complex variety of habitats
•   Rivers and lakes are also used as source of irrigation            and biological diversity
    of crops                                                          - Need for flood management that works with the forces
•   Flood ways were utilized to prevent flooding of nearby            of nature
    communities and damage of crops                                             Air and Water Treatment
•   Aqueducts were invented and built by later civilization       •   Some of the gases considered as criteria pollutants like
    such as the Romans and Greeks to deliver reliable water           NOx and O3, at moderate amount can bring a healthy
    supply                                                            ecosystem and can balance biodiversity.
•   Mixed forest and biodiversity play an unquestionable          •   However, due to excessive concentrations of these
    crucial role in water resources.                                  gases, the capacity of the environment to clean itself
•   Forests provide natural filtration and storage                    and to be resilient is lessened.
    systems to provide freshwater.                                •   Decreasing nitrogen deposition enhances plant
•   Roots and leaves of trees create conditions that                  species diversity and relative species richness in
    promote the infiltration of rainwater into the soil to fill       grasslands.
    up the aquifer systems with groundwater while
•   Excessive nitrogen stimulates presence of nitrogen-          •   Implementation of regulations and the worldwide
    loving plant species but reduces the occurrence of               protocols such as Montreal Protocol and Kyoto
    plant species adapted to low nitrogen availability.              Protocol
•   Nitrogen decreases the resilience of forests to other        •   Cartagena Protocol has ten Pacific parties, Fiji, Kiribati,
    environmental stresses such as drought, high wind,               Marshall Islands, Nauru, Niue, Palau, Papua New
    frost, pests and diseases.                                       Guinea, Samoa, Solomon Islands, and Tonga
•   Concentration limit of nitrate in drinking water is too          - to ensure the safe transport, handling and use of living
    high to protect natural ecosystems particularly the              modified organisms (LMO) resulting from modern
    plant species.                                                   biotechnology that may have adverse effects on
•   Widespread exceedance of nitrogen critical                       biodiversity
    concentrations will adversely affect the structure and           - adopted in January 29, 2000 and was enforced in
    function of the ecosystems.                                      September 11, 2003
•   Weakens the resilience of soil and the plants                    - linked to the Convention on Biological Diversity,
•   From 1990 to 2006, there was also an extensive                   which helps to protect Pacific communities and
    vegetation damage due to ozone.                                  biodiversity from the consequences of living modified
•   When ozone is high, it can promote early flowering,              organisms
    affecting the synchronization of pollinators and                 - requires having environments in place through proper
    flowers.                                                         legislative     frameworks,      laboratory    facilities,
•   Ozone also damages the leaves of salad crops                     technology and technical capabilities
    reducing their market value.                                 •   Locally, there should be a tight implementation of
•   In 2000, ozone pollution reduced wheat yield by 14%              environmental laws being practiced by industries and
    and the tomato yield by 9%.                                      communities alike to prevent further damage of
•   Negative impacts on vegetation reduces the sink                  biodiversity from air pollution and water pollution. We
    capacity for carbon dioxide and ozone, enhancing their           also have to ensure that whatever treatment we employ,
    atmospheric concentrations and affecting the global              we do not promote just the mass pollution transfer from
    water cycle.                                                     one matrix of the environment to another.
•   Indirect global warming effect of ozone might be of          •   Tight implementation of environmental laws being
    similar magnitude as the direct effect.                          practiced by industries and communities to prevent
                                                                     damage of biodiversity from air pollution and water
•   Soils store air pollutants temporarily and thus affects
                                                                     pollution
    water purification.
                                                                 •   We also have to ensure that whatever treatment we
•   Stored pollutants will adversely affect soil functioning
                                                                     employ, we do not promote just the mass pollution
    (e.g., microbes and invertebrates)
                                                                     transfer from one matrix of the environment to another.
•   Nitrogen leaches from forest soil at a Carbon: Nitrogen
    ratio below 23 in the organic layer causing algal bloom    Week 15: Gene Therapy and Genetically
    and eventually eutrophication                              Modified
       Genetically Modified Organisms (GMOs)                        -   In 1993, FDA approved Bovine somatotropin
   •   Products of artificial manipulation and alteration of a          (bST), a metabolic protein hormone used to increase
       species’ genetic material in a laboratory using genetic          milk production in dairy cows for commercial use.
       engineering                                                  -   In 1994, U.S. FDA approved the Flavr Savr tomato
   •   Plant, animal, bacteria, and virus genes may be                  for sale on grocery stores; this kind of tomato has a
       combined or may be crossbred to produce another kind             delayed-ripening effect allowing a longer shelf life
       of species that do not naturally occur in the environment.       than conventional tomatoes.
   •   GMOs in agricultural sector                                  -   In 1995, Bt Potatoes and Corn, and Roundup
       - for better yield                                               Ready Soybeans were approved safe by the
       - for better resistance to drought and flood situations          Environmental Protection Agency (EPA).
       - to artificially develop other traits in plants, such as    -   In 1996, weeds resistant to glyphosate, the
       resistance to browning and pests                                 herbicide used with many GMO crops, were
       - enhanced nutrition                                             detected in Australia.
   •   Are the benefits already proven to the market?                     - super weeds are 7 to 11 times more resistant to
   •   Humans seem to be disinterested in preserving genetic            glyphosate than the standard susceptible population
       diversity the natural way                                          - Dolly, the sheep, the first cloned animal was
                                                                        born
                                                                    -   In 1997, the European Union rules in favor of
History of GMOs                                                         mandatory labeling on all GMO food products,
        - As early as 1935, DNA was discovered by Russian               including animal feed.
            scientist Andrei Nikolaevitch Belozersky                -   In 1998, a genetically modified papaya in Hawaii was
        - In 1973, recombinant DNA, rDNA, was done by                   found to be resistant to the Ring spot virus and
            Professors Herbert Boyer and Stanley Cohen                  produced the Bacillus thuringiensis (Bt) toxin, an
        - In 1975, in Asilomar Conference, a group of                   insecticide that is not harmful to humans
            biologists with lawyers and doctors gathered to         -   Starting 1999, over 100 million acres worldwide are
            create guidelines for the safe use of genetically           planted with genetically engineered seeds.
            engineered DNA.                                         -   In the Philippines in 2000, the first golden rice was
        - In 1980, there was a court case between the                   developed to address the vitamin A deficiencies
            genetics engineer at General Electric Co. and the       -   a variety of rice (Oryza sativa) modified genetically
            U.S. government to secure a patent for a bacterium          to biosynthesize beta-carotene, a precursor of
            with an appetite for crude oil, to help solve the           vitamin A in the edible parts of rice
            problem on oil spill                                    -   additional three beta-carotene synthesized genes
        - In 1982, Food and Drug Administration (FDA)                   make golden rice different from its parental strain
            approved the first GMO - Humulin, an insulin            -   cannot produce the pigment in the endosperm,
            produced by genetically engineered E. coli bacteria         where photosynthesis does not occur unlike its
            on the market.                                              parent strain.
       -  led to rising opposition from environmental and anti-       -   causing an imbalance in the ecology of a region just
          globalization advocates since this may compromise               exotic species would do
          food, nutrition and financial security                      -   accident in engineering the genetics of a virus or
       - In 2003, a Bt-toxin-resistant caterpillar-cum-                   bacteria could cause a serious epidemic when
          moth, Helicoverpa zea, was found feasting on GMO                released
          Bt cotton crops in the southern United States.              -   minor medical problems
       - In 2006, a development of animals with traits that are       -   death
          desirable compared with their natural counterparts
          was conducted using Yorkshire pigs that were                                Gene Therapy
          genetically modified to produce a type of pig that      •   a method just like having GMOs but normally adenovirus
          produces enzyme phytase in its saliva to digest             is used to introduce the modified Deoxyribonucleic
          plant phosphorus, unlike their counterpart pigs.            acid (DNA) into a human cell, altering the targeted site
       - In 2011, research in eastern Quebec found Bt             •   conceptualized in 1972, but the first attempt of modifying
          toxins in the blood of pregnant women and showed            human DNA was performed in 1980 by Martin Cline
          evidence that the toxin could be passed to the          •   In 1980s, gene therapy for Severe Combined
          babies.                                                     Immunodeficiency Disease (SCID), a very rare, life-
       - In 2012, a French farmer Paul Francois sued                  threatening disease that a child may be born with, was
          Monsanto for chemical poisoning he claimed was              explored
          caused by its pesticide Lasso, part of the Roundup          - done by taking the child’s blood and putting the normal
          Ready line of products. He won the case.                    gene into the blood cell
       - As early as 2013, corn and the poplars have been             - child is then given a blood transfusion with his or her
          genetically modified and used to produce biofuel            own blood that has the normal gene inserted
          which have been used as an efficient substitute of          - gene then works itself into the immune system and
          petroleum products                                          lessens the symptoms of the disorder
       - In 2014, the patent on the Roundup Ready line of         •   1st approved gene therapy clinical research in the US
          genetically engineered seeds ended.                         took place on 14 September 1990, at the National
       - All these conversions involve mutation.                      Institutes of Health (NIH), under the direction of William
       - Science agrees that there is a probability that the          French Anderson.
          majority of mutations attempted by a species would      •   In 1993, the first somatic treatment that produced a
          fail miserably and the individual plant/animal would        permanent genetic change was performed.
          not survive.
                                                                  •   The first commercial gene therapy product Gendicine
Issues on GMOs                                                        was approved in China in 2003 for the treatment of
       - safety                                                       certain cancers.
       - right to modify organisms and remove their original
                                                                  •   Due to some clinical successes since 2006 Gene
          aspects
                                                                      Therapy regained researchers’ attention but still
       - ecological problem
                                                                      considered as an experimental technique.
•   In 2016, the Committee for Medicinal Products for                  - should make the doctors feel comfortable with the
    Human Use of the European Medicines Agency                         common problems of gene therapy and inspire others to
    endorsed a gene therapy treatment called Strimvelis                proceed to deeper studies and to address the dilemma
    that was approved by the European Commission in June               on the implementation of Gene Therapy
    2018                                                        Week 16: Nanotechnology
•   In recent years, the delivery of bacterial or viral            •   The study and application that can be used across all
    gene on the targeted site was also discovered.                     the other science fields, such as chemistry, biology,
    - An emerging family of vectors involves bacteria of               physics, materials science, and engineering
    various genera.                                                •   The study and application that can be used across all
    - bacteria are naturally capable of homing to tumors               the other science fields, such as chemistry, biology,
    when systemically administered resulting in high levels            physics, materials science, and engineering
    of replication locally                                         •   It is ‘convergent’ because it brings together sectors of
    - invasive species can deliver heterologous genes intra-           science that were previously separated
    cellular for tumor cell expression                                 - e.g. (deoxyribonucleic acid) DNA silicon chips,
•   Gene or cell therapies have emerged as realistic                   converging between semiconductor science (inorganic
    prospects for the treatment of cancer, and involve                 chemistry) and biology, with applications in the medical
    the delivery of genetic information to a tumor to                  industry.
    facilitate the production of therapeutic proteins.             •   It also involves design, characterization, production and
•   This area still needs further studies before an efficient          application of structures, devices and systems by
    and safe gene medicine is achieved, primarily                      controlling shape and size at the nanometer scale.
    developing the means of targeting genes to tumors              •   This technology is ‘enabling’ in the sense that it provides
    safely and efficiently.                                            the platform, and the tools to realize certain products.
      Actions on Gene Therapy and GMOs                             •   To make things simpler to imagine, we need to know
•   Agroecology is a study that suggest novel                          how materials that we commonly have known work at
    management approaches on farming systems that may                  the nanoscale.
    help address the concern on the health of biodiversity                  Applications of Nanotechnology
    and of the consumers of GMOs.                               In medicine, numerous applications of this field:
    - should evaluate the performance of the specific GMO       - more effective drugs for conditions such as high blood
    and whether it poses risk to human health                   pressure
•   Further basic and translational research, as well as        - assisted by the view of these molecule afforded by X-ray lasers
    clinical experiences, to outline functional mechanisms,     - simulate biological mechanisms to monitor a cancer cell while
    predictive approaches, patient-related studies and          it is treated by drug-bearing nanoparticles
    upcoming challenges should be done to address               - “nanobots”, molecular-scale workers that can employ
    existing problems in the field of development and future    molecular processes within cells which eventually can deliver
    perspectives in gene therapy.                               drugs to specific molecular sites or even carry out surgery
- diagnose prevalent contagious diseases like HIV/ AIDS,               - Its activity has been enhanced with the discovery that
malaria, tuberculosis, etc. with screening devices using               the bactericidal properties of Ag nanoparticles (1-100
nanotechnology                                                         nm) are dependent on both their size and shape.
   • Water purification systems, with nanomaterials and            •   In agriculture, novel techniques of nanotechnology
       utilizing new membrane technologies with variable pore          applications are applied to breed crops with higher levels
       sizes as filters                                                of micronutrients, to detect pest, and to
       - forward-osmosis membrane technology of Hydration              control processing of food.
       Technologies                                                    - Ultra-small probes on earth surfaces for agricultural
   • used to prepare heat-resistant and self-cleaning                  applications and control of soil, air, and water
       surfaces, such as floors and benchtops.                         contamination are also developed by nanotechnology.
   • Nanoparticles of silicon dioxide or titanium dioxide can      •   Bio nanotechnology provides feasible solutions, e.g.,
       also make a surface repel water, which prevents stains.         support of cleaner production methods, provision of
   • Detergent molecules self-assemble into a sphere to                alternative and renewable energy sources, and source
       form a micelle that allows the detergent to trap oils and       reduction into the manufacturing process.
       fats within the cavity of the sphere that eventually aids   •   Nanotechnology helps in energy consumption like in the
       washing                                                         use of graphene into a coating material resulting in the
   • Zeolites are silicon oxide and aluminium oxide that have          need for only one layer, which does not require a
       specific nanoporous cage-like structures allowing it to         multifunctional film coating.
       absorb molecules, i.e., heavy metals and compounds          •   Nanoscale chemical reagents or catalysts are smaller in
       that cause odor                                                 sizes yet increase the reaction rate, thus lessening input
   • For contamination of Arsenic in soil and water, a simple          of raw materials.
       and cheap but effective way of removing the                           Challenges of Nanotechnology
       contaminant with TiO2 nanoparticles.                        •   Nanotechnology, when used in environmental impact
   • Availability of a nanotechnology-inspired detector from           assessments and in toxicology testing, may bring a
       Washington, which can sense the smallest amount of              possibility of e-waste bins at recycling centers or even in
       radiation, made the detection of a nuclear leak faster          sanitary landfills. This technology involves intricately
       and more accurate at the Fukushima Daiichi Nuclear              engineered nanostructures that could screen what
       Power Plant                                                     happen to these e- wastes, and to possibly lessen
   • Chlorinated compounds, i.e., chlorinated solvents and             environmental consequences. This may be feasible but
       pesticides; polychlorinated biphenyls (PCBs); and               may be difficult.
       brominated compounds are major environmental                •   The mineral-based nanoparticles found in cosmetics,
       contaminants that can be reduced using nanoscale                paints, clothing and other products are questioned on
       metal particles, such as FeO and Fe-Ni in conjunction           how they affect the environment as they go through
       with iron filings [Fe(0)]                                       sewerage treatment plants untreated due to their very
   • Silver (Ag) has long been known to exhibit strong                 small diameters.
       antimicrobial properties.
    - They can be carried down by fine silts or microplastics         we give up the benefits this technology can provide
    with both inorganic and organic pollutants.                       to the society?
    - Thus, may even affect our water source                      •   Issues raised may be further studied and modification of
    - In the 1980s, a semiconductor plant contaminated the            nanotechnology methods may be done. For example,
    ground-water in Silicon Valley, California (Zhang et al,          altering the composition of graphene, known to be one
    2011).                                                            of the most advanced materials for structural
•   Carbon nanotubes used in the manufacture of memory                improvement; substitution of silicon for electronic
    storage, electronics, batteries, etc. were found to have          devices, thermal transferring, and fire retardant, to
    unknown harmful impacts to the human body, by                     become more environmentally friendly. Some studies
    inhalation into lungs, comparable to asbestos fiber.              also found microorganisms that can decompose
    - The pulmonary toxicological evaluation of single-wall           graphene to make it less toxic to the environment
    carbon nanotubes indicated that it is more toxic than             (Zhang et al, 2011).
    carbon black and quartz once it reaches the lungs while       •   It is imperative therefore, that the society is give
    multifocal granulomas were produced when rats were                enough knowledge on how nanomaterials work for
    exposure to single-wall carbon nanotubes.                         the benefit of society.
•   Due to its size, nanoparticles are difficult to analyze and   Week 17: Climate Change and Environmental
    this lack of information and methods of characterizing
    nanomaterials makes it a challenge to detect its
                                                                  Awareness
    concentration in air or in any matrix of the                                       Climate Change
    environment.                                                  •   Pollutants may be from stationary sources, i.e.,
    - Predicting the toxicity of a nanomaterial rely heavily on       industrial plants and other commercial or residential
    the information of the chemical structure since minor             establishments that do combustion of fossil fuels; or
    changes of chemical function group could drastically              from mobile sources such as motor vehicles.
    change its properties.
•   Point to point risk assessment at all stages of               •   Effects of primary pollutants are direct, i.e., respiratory
    nanotechnology should then be conducted to ensure the             illnesses or human toxicity either on short term but more
    safety on human health and environment.                           on long term exposure.
•   The risk assessment should include the exposure risk          •   Pollutants may be from stationary sources, i.e.,
    and its probability of exposure, toxicological analysis,          industrial plants and other commercial or residential
    transport risk, persistence risk, transformation risk and         establishments that do combustion of fossil fuels; or
    ability to recycle. However, this is quite expensive due to       from mobile sources such as motor vehicles.
    the difficulty in detecting nano particles.                   •   Effects of primary pollutants are direct, i.e., respiratory
        Dilemma of Utilizing Nanotechnology                           illnesses or human toxicity either on short term but more
•   With the identified potential hazard that nanoparticles           on long term exposure.
    can bring to human health and the environment, shall
•   Direct impacts are coming from carcinogens (causing            •   Causes dilution of salt of the ocean and disrupt natural
    cancer), mutagens (damage the genes) and                           ocean currents
    teratogens (cause abnormalities in the embryo).                •   Ocean currents control temperatures by bringing
•   When pollutants are formed when a substance reacts                 warmer currents into cooler areas and cooler currents
    with one or two more substances to form a more                     into warmer areas.
    obnoxious substance, i.e., photochemical smog, a               •   Affects albedo, the ratio of the light reflected by any
    product of five criteria pollutants namely, oxides of              part of the earth's atmosphere
    nitrogen and sulfur (NOx, Sox), volatile organic               •   When snow melts, the earth’s temperature inclines to
    compounds (VOCs), carbon monoxide (CO) and the                     increase resulting to global warming.
    particulate matter (PM), these are considered as having        •   Sea-level rise that will greatly affect low-lying coastal
    indirect effects of secondary pollutants.                          areas where a large populations dwell
                   Global Warming
•   Due to the greenhouse gases, aside from water vapor,                  Changing wildlife adaptations and cycles
    that are present in the atmosphere like carbon dioxide
                                                                   •   Species such as spruce bark beetles in Alaska are just
    (CO2), methane (CH4), and nitrous oxides (NOx).
                                                                       supposed to appear on warmer months but since the
•   When some ultraviolet rays, considered as short-wave               temperature has increased, they started to appear all
    radiation, enter the atmosphere for biological processes           year-round leaving the forest dead since they chew on
    such as photosynthesis, the radiation is converted into            the spruce trees.
    the form of long-wave radiation and is absorbed by the         •   Polar bears also are starting to decrease their
    greenhouse gases in the atmosphere and produces a
                                                                       population since the polar ice caps have started to melt
    general warming effect.
                                                                       down decreasing their possible habitats.
•   Keeps our planet warm and prevent warmer air from
    leaving our planet
•   Global warming potential (GWP) of the natural
    greenhouse gases are small as compared to other                                    Spread of Diseases
    anthropogenic gases from the burning of fossil fuels,
                                                                   •   Migratory species are supposed to migrate every
    power plants, transportation vehicles and other
                                                                       season in a region where there is sufficient food and
    industrial processes.
                                                                       water.
•   These man-made greenhouse gases plus the increase
                                                                   •   Areas where these species are supposed to go are
    in concentration of the natural greenhouse gases cause
                                                                       already dry and thus, for survival these species would
    the adverse Global Warming.
                                                                       transfer to areas with water supply.
•   Deforestation contributes to global warming and affects
                                                                   •   Since these species are not endemic in the new found
    biodiversity since as rainforest are lost, wildlife habitats
                                                                       environment, they may carry some microorganisms
    are also lost
                                                                       that may mutate in which humans have no built-
                       Melting Ice Caps                                immunity
              Stratospheric Ozone Depletion                      •   The following reactions will then occur producing the
•   A thin layer of ozone (O3) is maintained at the                  obnoxious Cl- radical which is very reactive to the point
    stratosphere so as to protect us from the harmful                of in the stratosphere: destroying 100,000 molecules
    ultraviolet rays from the sun.                                   of O3
•   Only a thin layer is needed, when larger O3                  •   HOCl + hv → Cl + OH- (Equation 7)
    concentration occurs, meteorological parameters, i.e.,       •   Cl + O3 → ClO + O2 (Equation 8)
    temperature and wind will bring down O3 in the               •   OH-+ O3 → HO2 + O2 (Equation 9)
    troposphere causing respiratory problems on humans           •   Worst case will occur if available X is Br- which is 100
    and thus can be considered as a criteria pollutant.              times more reactive than Cl- (Sherwood Rowland,
•   Ozone depletion occurring in the stratosphere                    2006).
    therefore is a normal photolytic process as well as O3       •   Although there is direct relationship between Global
    formation.                                                       warming and Stratospheric Ozone Depletion, the
•   The reactions below occur to maintain such thin layer            correlation on the greenhouse gases as they contribute
    of O3.                                                           to creating the cooling conditions in the atmosphere may
    - O2 + UV( < 242 nm) → O + O (Equation 1)                        lead to ozone depletion.
    - O + O2 + M → O3 + M (Equation 2)
    - O3 + UV or visible → O + O2 (Equation 3)                                          Acid Deposition
•   Due to the presence of substance X, which may either         •   When Sox and NOx react with particulate matters (dry)
    be Cl-, Br-, NO, OH- coming from substances made of              or with water vapor (wet), acid deposition occurs as it
    chloroforms, or bromine-based substances used as                 causes surface water acidification and affect soil
    aerosols, refrigerants, fire retardants and the like             chemistry.
                                                                 •   At pHs lower than 5, may affect the fertilization of fish
•   The ozone formation and destruction may now be                   eggs and can kill adult fish.
    represented as equations below:                              •   As lakes and rivers become more acidic biodiversity is
    - X + O3 → XO + O2 (Equation 4)                                  reduced. Many soil organisms cannot survive if the soil
    - XO + O → X + O2 (Equation 5)                                   pH is below 6.
    - O3 + O → O2 + O2 (Equation 6)                              •   Death of these microorganisms can inhibit
•   As an intermediate product, let say X is Cl-, ClONO2 will        decomposition and nutrient recycling since the
    be produced.                                                     enzymes of these microbes are denatured by the acid or
•   This substance is inert and will just be deposited on both       are changed in shape so they no longer function.
    the northern and southern polar regions due to winds as      •   Deposition of sulfur and nitrogen oxides affect the ability
    the earth rotates.                                               of leaves to retain water when under stress.
•   The problem occurs when the ClONO2 reservoirs will           •   The low pH of soil will also allow the faster mobility of
    be exposed to direct sunlight when a part of polar               heavy metals present in the soil, i.e., Pb2+, Cu2+, Al3+
    region experiences straight six months 24/7 daytime.             and thus, may contaminate the growing plants which
    may then bioaccumulate the heavy metal concentration        •   Freezing rain or ice storms develops in some areas
    as it is passed from higher trophic level to another.           with a temperature inversion in a cold area because
•   As these impacts affect the aquatic and terrestrial             snow melts as it moves through the warm inversion
    ecosystems, it is also imperative to connect its impact         layer.
    on climate change.                                          •   The rain continues to fall and passes through the cold
                     Thermal Inversion                              layer of air near the ground.
•   The major component of photochemical smog,                  •   As it moves through this final cold air mass, it becomes
    peroxylacetyl nitrate (PAN) is a combination of all             "super-cooled" drops, cooled below freezing without
    these criteria pollutants.                                      becoming solid.
•   PAN is a transporter for NOx into rural regions and         •   Intense thunderstorms and tornadoes are also
    causes ozone formation in the global troposphere                associated with inversions because of the intense
    which can decrease visibility especially in elevated            energy that is released after an inversion blocks the
    places.                                                         normal convection patterns of a region.
•   The pollutants that come from sources, i.e., industrial     •   Its profiles lead to sea surface temperature to decrease
    chimney or stack mix with the air.                              on the seasonal time scale via heat exchange at the
•   The mixed air normally rises to the atmosphere. In a            bottom of the mixed layer, which balances climatological
    normal cycle of thermal inversion, an unstable air mass         atmospheric cooling in fall and winter.
    and air constantly flow between the warm and cool           •   El Niño is normal climate pattern that describes the
    areas.                                                          unusual warming of surface waters in the eastern
•   This allows fumigation of the mixed air on a higher             tropical Pacific Ocean also known as the “warm phase”.
    elevation.                                                  •   The opposite of it is La Niña, the “cool phase” which is
•   Due to increased concentrations of the pollutants,              a pattern that describes the unusual cooling of the
    during an inversion episode, temperatures increase              surface waters of the region.
    with increasing altitude and this disrupts the              •   These phenomena are supposed to occur perennial and
    movement of the mixed air to a higher level since the           globally, on one end of the equator and the other side of
    warm inversion layer then acts as a cap or a layer that         the equator.
    forms stable air masses.                                    •   However, abnormalities in the occurrences of these
•   It is also affected by weather conditions, or it may also       phenomena cause widespread and severe changes in
    occur in some coastal areas because of upwelling of             the climate.
    cold water that lowers the surface air temperature.         •   Rainfall increases drastically in Ecuador and northern
•   Topography or man-made barriers like high rise                  Peru, contributing to coastal flooding and erosion due
    buildings can also create a temperature inversion.              to the convection above warmer surface waters.
•   The cold air may be blocked by these barriers and then      •   Increased rains brings floods that may destroy
    pushes under the warmer air rising from the source              homes, schools, hospitals, businesses, and crops.
    thus, creating the inversion.
•   On the other side of the world, it brings droughts that    •   Buy fuel-efficient vehicles with higher fuel economy
    threaten the supply of water and destruction of crops          performance
    affecting agriculture.                                     •   Since      the   environment      is   contiguous,     the
•   Stronger El Niño and La Niña events also disrupt               responsibilities should also be shared not only locally,
    global atmospheric circulation bringing colder                 regionally and even globally.
    winters, unusual heavy rains and flooding in desert        •   Countries come together to come up with different
    areas and other weather abnormalities.                         protocols and agreements so as to help each other
                        Disaster Risk                              solve Climate Change.
•   The physical health after the disasters brought about by   •   Kyoto Protocol is an international agreement linked to
    Climate Change such as droughts and floods are not all         the United Nations Framework Convention on Climate
    that matters.                                                  Change where the Philippines is one of the
•   Depression, anxiety, grief and other manifestations of         signatories.
    loss and conflict may occur when familiar environments         - commits each signatory or member by setting
    are damaged and social connections threatened.                 internationally binding emission reduction targets
•   With all these adverse impacts due to climate change,          - adopted in 1997 but the first commitment period started
    actions must be done.                                          in 2008 and ended in 2012
                Environmental Awareness                            - countries committed to cut by 2% their CO2
•   One of the main culprit of Climate Change is the               emissions until 2050 to help in solving the problem on
    increasing CO2 present in the atmosphere coming from           Climate Change
    industrial sources and mobile sources.                         - estimated that by 2050, the world will have an
•   Shifting of fossil fuels as sources of energy to               approximate 80% reduction on CO2 emissions
    renewable energy resources, i.e., solar, wind, or hydro    •   Montreal Protocol is gradually eliminating the
    is one way to decrease generation of CO2                       manufacture, trading and consumption of ozone
•   For spaces that need air conditioning or heating, they         depleting substances (ODS) to help the ozone layer
    could be sealed or ensure adequate insulation to have          recuperate from the hole it has attained due to
    more energy efficiency.                                        increasing ODS.
•   When buying appliances such as refrigerators, washing      •   It is signed by 197 countries including the Philippines.
    machine and the like, buy those that are tagged as                         Disaster Risk Management
    energy efficient.                                          •   Due to global warming and the melting of ice caps at
•   Lessen consumption of energy and even water since              the Polar regions, sea level rise is now a threat to
    it takes a lot of energy in pumping and heating water.         coastal cities.
•   Consume less of meat products since it takes a lot of      •   There are low-lying regions like that of Cartagena de
    energy in growing, processing, packaging and shipping          Indias, surrounded by the Caribbean and its interior
    these products.                                                bodies of water that are feared of being wiped out of
•   Use better bulbs like Light Emitting Diode (LED) bulbs         the map if they do not act quickly.
    to lessen up to 80% your energy consumption.
•   With the help of Climate and Development                           Strategy" Foro de Ministros del Medio Ambiente de
    Knowledge Network (CDKN), a program funded by the                  America Latina y El Caribe.
    United Kingdom Department for International                    •   Just after the publication of this plan for Cartagena de
    Development (DFID) and the Netherlands Directorate-                Indias, Philippines was struck by typhoon Haiyan also
    General for International Cooperation (DGIC) for the               known as typhoon Yolanda in the Philippines.
    benefit of developing countries, the city of Cartagena de      •   The national disaster risk reduction and
    Indias included the adaptation to climate change in the            management plan (NDRRMP) of the Philippines for
    district development plan as a cross-cutting topic of              2011 to 2028 was revisited and was prioritized.
    great importance in the territorial use of land in the             - a plan that guides the country on how sustainable
    city, which, in turn, articulates with other planning tools,       development can be achieved through inclusive growth
    such as the Territorial Land Use Plan (TLUP) and the               -     while building the adaptive capacities of
    Risk Management Plan.                                              communities, increasing the resilience of vulnerable
•   This will help the city to become more resilient to                sectors
    climate phenomena.                                                 - optimizing disaster mitigation opportunities
•   The plan will involve the citizens of the city in the design        - aims to strengthen the capacity of the national
    and creation of an adapted neighborhood in a zone                  government and the local government units (LGUs)
    where the socio-economically vulnerable communities                together with partner stakeholders
    are located.                                                       - to build the disaster resilience of communities
•   This is a declaration of Leaders of APEC, gathered in              - to institutionalize arrangements and measures for
    Cartagena de Indias, Colombia, October 24-26, 2010,                reducing disaster risks
    during the "XII Cumbre de Jefes de Estado y de
    Gobierno del Mecanismo de Dialogo y Concertacion de
    Tuxtla“
    - "emphasize the importance of the Hyogo Framework
    for Action aimed to raise awareness, mobilize action
    and build global, regional, national and local, existing
    practices to reduce loss of life, social and
    environmental
    needs of communities following a disaster, including
    climate change adaptation
    - highlights the work of the Secretariat of the
    International Strategy for Disaster Risk Reduction
    (ISDRR) in its role to promote, and monitor its
    application, particularly through the campaigns
    'Disaster risk reduction begins at school', 'Safe
    hospitals' and 'Making cities resilient', promoted by the