Orilissa is a brand-name prescription drug that comes that is FDA-approved to treat moderate to severe pain caused by endometriosis in women. Endometriosis is a painful disorder in which the endometrial tissue grows outside of the uterus. Currently, there are no generic versions of Orilissa on the market. The average Orilissa price is about $1,672.39 for 4, 150mg blister pack of 7 tablets. With an Orilissa coupon, you can pay about $1,132.00 for 4, 150mg blister pack of 7 tablets at participating pharmacies near you.
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SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.
Prices updated: 11/01/2025
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Orilissa is a brand-name prescription drug that comes that is FDA-approved to treat moderate to severe pain caused by endometriosis in women. Endometriosis is a painful disorder in which the endometrial tissue grows outside of the uterus. Currently, there are no generic versions of Orilissa on the market. The average Orilissa price is about $1,672.39 for 4, 150mg blister pack of 7 tablets. With an Orilissa coupon, you can pay about $1,132.00 for 4, 150mg blister pack of 7 tablets at participating pharmacies near you.
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
| Pharmacy | Orilissa Retail Price | Orilissa SingleCare Price |
|---|---|---|
| CVS Pharmacy | $1429.12 | $1157.80 |
| Walmart | $1454.04 | $1225.28 |
| Walgreens | $1457.96 | $1233.12 |
| Kroger Pharmacy | $1454.04 | $1137.64 |
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
Orilissa is a brand-name prescription drug that comes that is FDA-approved to treat moderate to severe pain caused by endometriosis in women. Endometriosis is a painful disorder in which the endometrial tissue grows outside of the uterus. Currently, there are no generic versions of Orilissa on the market. The average Orilissa price is about $1,672.39 for 4, 150mg blister pack of 7 tablets. With an Orilissa coupon, you can pay about $1,132.00 for 4, 150mg blister pack of 7 tablets at participating pharmacies near you.
On average the cash price of Orilissa is approximately $1,672.39 for 4, 150mg blister pack of 7 tablets. You can save on your prescription and owe as little as $1,132.00 for 4, 150mg blister pack of 7 tablets out-of-pocket when you use a SingleCare Orilissa coupon at checkout. Pharmacies that accept the SingleCare discount card include CVS Pharmacy, Target, Walmart Pharmacy, and Walgreens.
The copay for your Orilissa prescription varies based on your insurance coverage. You can use a SingleCare savings card to lower your Orilissa price and pay about $1,132.00 for 4, 150mg blister pack of 7 tablets. To compare Orilissa pricing, ask the pharmacist to run your card before you buy your prescription. In some cases, SingleCare may offer the lowest price.
Orilissa is typically not covered by Medicare and is likely to be quite expensive. To get a discount on your Orilissa prescription and refills, you can use a free SingleCare discount card and pay around $1,132.00 for 4, 150mg blister pack of 7 tablets. Ask your pharmacist to apply your savings card during your next checkout to start saving on Orilissa and other prescriptions.
Orilissa is a brand-name drug that is manufactured by AbbVie Inc. A generic version of Orilissa is not currently available.
Orilissa is used to treat pain symptoms from endometriosis, which is a chronic disease in women that can cause infertility, painful periods, and severe pelvic pain in between periods. Orilissa may also help to reduce pain during sexual intercourse.
Orilissa is an FDA-approved, prescription-only medication manufactured by AbbVie Inc. The active ingredient in Orilissa is elagolix. Orilissa is a GnRH receptor antagonist that works to lower levels of progesterone and estradiol, which are the primary female sex hormones. These hormones are the main cause of endometrial growth.
Orilissa is available as a 150 mg and 200 mg oral tablet. Both options lower estrogen by varying amounts so you and your doctor can choose the dosage that will work best for you. Like other medications, Orilissa may be used for other purposes not listed here. If you have any questions, you should ask your pharmacist or consult with your doctor for additional information before using Orilissa.
Never take Orilissa more often than prescribed or use it longer than prescribed.
Possible side effects of Orilissa include headaches, nausea, joint pain, reduced or absent menstrual periods, trouble sleeping, hot flashes, and night sweats. If these symptoms persist or worsen, report them to your doctor or healthcare professional. You can ask your healthcare provider or pharmacist about other side effects associated with Orilissa to determine if it is right for you.
Seek medical advice immediately if you experience serious side effects, such as allergic reactions. Signs and symptoms of an allergic reaction to Orilissa include skin rashes, itching, hives, or swelling of the tongue, face, or lips.
Orilissa can also cause mood changes. Some people taking Orilissa may experience depression, suicidal thoughts, anxiety, or other mood changes.
Orilissa may cause bone loss, or a decrease in bone mineral density (BMD). Another serious side effect of Orilissa includes liver injury. Consult your healthcare provider if you experience yellowing of the eyes or skin, fatigue, nausea, vomiting, dark-colored urine, bruising, or right upper stomach pain. Consult your doctor or healthcare provider on other possible side effects, warnings, and precautions before using Orilissa.
Gerardo Sison, Pharm.D., graduated from the University of Florida. He has worked in both community and hospital settings, providing drug information and medication therapy management services. As a medical writer, he hopes to educate and empower patients to better manage their health and navigate their treatment plans.
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Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
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© 2025 SingleCare Administrators. All rights reserved