Creon (pancrelipase) is an FDA-approved medication that is prescribed to patients with certain pancreatic conditions like exocrine pancreatic insufficiency (EPI), cystic fibrosis, or chronic pancreatitis. It provides certain enzymes needed for digestion. There is no generic version of Creon for sale. The retail price of Creon is $1,674.71 for 100, 36000-114000unit capsules delayed release particles of Creon, but you could pay $1,182.01 for 100, 36000-114000unit capsules delayed release particles with SingleCare's free coupons.
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SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
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Prices updated: 11/01/2025
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Creon (pancrelipase) is an FDA-approved medication that is prescribed to patients with certain pancreatic conditions like exocrine pancreatic insufficiency (EPI), cystic fibrosis, or chronic pancreatitis. It provides certain enzymes needed for digestion. There is no generic version of Creon for sale. The retail price of Creon is $1,674.71 for 100, 36000-114000unit capsules delayed release particles of Creon, but you could pay $1,182.01 for 100, 36000-114000unit capsules delayed release particles with SingleCare's free coupons.
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
| Pharmacy | Creon Retail Price | Creon SingleCare Price |
|---|---|---|
| CVS Pharmacy | $1522.00 | $1250.00 |
| Walmart | $1550.00 | $1479.00 |
| Walgreens | $1550.00 | $1370.00 |
| Kroger Pharmacy | $1549.00 | $1197.00 |
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
Creon (pancrelipase) is an FDA-approved medication that is prescribed to patients with certain pancreatic conditions like exocrine pancreatic insufficiency (EPI), cystic fibrosis, or chronic pancreatitis. It provides certain enzymes needed for digestion. There is no generic version of Creon for sale. The retail price of Creon is $1,674.71 for 100, 36000-114000unit capsules delayed release particles of Creon, but you could pay $1,182.01 for 100, 36000-114000unit capsules delayed release particles with SingleCare's free coupons.
If you are paying out-of-pocket without insurance, the average cash price of Creon would be $1,674.71 for 100, 36000-114000unit capsules delayed release particles.
SingleCare provides free Creon coupons to enable patients to receive prescription savings of up to 80%. You can visit a participating pharmacy to inquire whether your prescription discount card is accepted. If it is, you could reduce your total amount due to only $1,182.01 for 100, 36000-114000unit capsules delayed release particles.
Your health insurance plan may provide you with coverage for this prescription drug. However, the copay of Creon will vary based on your insurance plan. You can discuss your savings with a pharmacist at any of SingleCare's participating drugstores to compare your savings options. In some instances, SingleCare may be less costly than your insurance. Contact your health insurance plan for more information about commercial prescription insurance coverage of Creon.
The majority of Medicare Part D and Medicare Advantage plans cover Creon, but your copay will depend on your plan and coverage stage. SingleCare's lowest price of $1,182.01 for 100, 36000-114000unit capsules delayed release particles could very well be lower than your Medicare copay. You can use your Creon savings card from SingleCare at local pharmacies to compare prices between Medicare and coupons from SingleCare.
Medicaid coverage will vary by state. Many state Medicaid plans cover Creon, but check your state Medicaid formulary to know for sure.
Print or download a SingleCare discount card to save on your monthly Creon cost.
Explore the manufacturer’s financial assistance program.
Look into different health insurance options. Find out whether Creon is included in the formulary.
Check out the formulary for different Medicare Part D or Medicare Advantage plans.
Ask your healthcare provider about other pancreatic enzyme alternatives.
Creon is a brand-name drug. Presently, there is no generic substitute for Creon.
The drug name for Creon is pancrelipase. In addition to Creon, pancrelipase is also manufactured under the brand names:
Drug prices fluctuate, but in general, Zenpep and Pertzye are more expensive than Creon, while Viokace and Pancreaze are less expensive. Talk with your healthcare provider about the version of pancrelipase that will be most effective and affordable for you. You can compare prices between the brand name versions of pancrelipase here.
Anne Jacobson, MD, MPH, is a board-certified family physician, writer, editor, teacher, and consultant. She is a graduate of University of Wisconsin School of Medicine and Public Health, and trained at West Suburban Family Medicine in Oak Park, Illinois. She later completed a fellowship in community medicine at PCC Community Wellness and a master's in Public Health at the University of Illinois-Chicago. She lives with her family near Chicago.
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Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
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© 2025 SingleCare Administrators. All rights reserved