Delineation of the role of the Mre11 complex in class switch recombination (Q47237271)

12 January 2018

title

Delineation of the role of the Mre11 complex in class switch recombination (English)

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12 January 2018

3

Krystyna H Chrzanowska

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12 January 2018

author name string

Aleksi Lähdesmäki

series ordinal

1

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12 January 2018

A Malcolm R Taylor

series ordinal

2

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12 January 2018

Qiang Pan-Hammarström

series ordinal

4

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12 January 2018

language of work or name

English

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publication date

26 January 2004

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12 January 2018

Journal of Biological Chemistry

published in

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volume

279

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issue

16

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page(s)

16479-16487

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The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response

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The RAG proteins and V(D)J recombination: complexes, ends, and transposition

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V(D)J recombination: RAG proteins, repair factors, and regulation

21 January 2018

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Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

21 January 2018

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Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)

21 January 2018

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Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase.

21 January 2018

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RNA editing enzyme APOBEC1 and some of its homologs can act as DNA mutators

21 January 2018

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Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice

21 January 2018

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Ku70 is required for late B cell development and immunoglobulin heavy chain class switching

21 January 2018

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Ku80 is required for immunoglobulin isotype switching

21 January 2018

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The SCID but not the RAG-2 gene product is required for S mu-S epsilon heavy chain class switching.

21 January 2018

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Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting

21 January 2018

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Deficiency in Msh2 affects the efficiency and local sequence specificity of immunoglobulin class-switch recombination: parallels with somatic hypermutation.

21 January 2018

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Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes

21 January 2018

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AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching

21 January 2018

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H2AX is required for recombination between immunoglobulin switch regions but not for intra-switch region recombination or somatic hypermutation

21 January 2018

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ATM is not required in somatic hypermutation of VH, but is involved in the introduction of mutations in the switch mu region

21 January 2018

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DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes

21 January 2018

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The translesion DNA polymerase zeta plays a major role in Ig and bcl-6 somatic hypermutation.

21 January 2018

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The role of polymerase eta in somatic hypermutation determined by analysis of mutations in a patient with xeroderma pigmentosum variant

21 January 2018

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Induction of somatic hypermutation in immunoglobulin genes is dependent on DNA polymerase iota.

21 January 2018

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New glimpses of an old machine

21 January 2018

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The Mre11 complex: at the crossroads of dna repair and checkpoint signalling

21 January 2018

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Nbs1 is essential for DNA repair by homologous recombination in higher vertebrate cells

21 January 2018

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Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome

21 January 2018

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The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder

21 January 2018

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ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

21 January 2018

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ATM-dependent phosphorylation of nibrin in response to radiation exposure

21 January 2018

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Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products

21 January 2018

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ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response

21 January 2018

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Substrate specificities and identification of putative substrates of ATM kinase family members

21 January 2018

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A family showing no evidence of linkage between the ataxia telangiectasia gene and chromosome 11q22-23.

21 January 2018

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Ataxia without telangiectasia masquerading as benign hereditary chorea

21 January 2018

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hMRE11: genomic structure and a null mutation identified in a transcript protected from nonsense-mediated mRNA decay

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M312796200

Characterization of ATM mutations in 41 Nordic families with ataxia telangiectasia

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M312796200

Sequencing of selected regions of the human immunoglobulin heavy-chain gene locus that completes the sequence from JH through the delta constant region

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M312796200

Structural analysis of human γ3 intervening regions and switch regions: Implication for the low frequency of switching in IgG3‐deficient patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312796200

Discriminating intrinsic and antigen-selected mutational hotspots in immunoglobulin V genes

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M312796200

The MRN complex: coordinating and mediating the response to broken chromosomes

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M312796200

Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312796200

Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M312796200

Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice.

21 January 2018

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The Mre11 complex and ATM: collaborating to navigate S phase

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M312796200

DNA-binding and strand-annealing activities of human Mre11: implications for its roles in DNA double-strand break repair pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312796200

DNA end-binding specificity of human Rad50/Mre11 is influenced by ATP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312796200

Promotion of Dnl4-catalyzed DNA end-joining by the Rad50/Mre11/Xrs2 and Hdf1/Hdf2 complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312796200

Human Rad50/Mre11 is a flexible complex that can tether DNA ends

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M312796200

Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M312796200

The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M312796200

Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M312796200

A mechanistic basis for Mre11-directed DNA joining at microhomologies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312796200

Regulation of Mre11/Rad50 by Nbs1: effects on nucleotide-dependent DNA binding and association with ataxia-telangiectasia-like disorder mutant complexes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312796200

An alternative mode of translation permits production of a variant NBS1 protein from the common Nijmegen breakage syndrome allele

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312796200

Activation-induced deaminase (AID)-directed hypermutation in the immunoglobulin Smu region: implication of AID involvement in a common step of class switch recombination and somatic hypermutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312796200

Mutations occur in the Ig Smu region but rarely in Sgamma regions prior to class switch recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312796200

Somatic hypermutation in the absence of DNA-dependent protein kinase catalytic subunit (DNA-PK(cs)) or recombination-activating gene (RAG)1 activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312796200

Reduced switching in SCID B cells is associated with altered somatic mutation of recombined S regions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312796200

Switch junction sequences in PMS2-deficient mice reveal a microhomology-mediated mechanism of Ig class switch recombination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312796200

Role for mismatch repair proteins Msh2, Mlh1, and Pms2 in immunoglobulin class switching shown by sequence analysis of recombination junctions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312796200

Alternative end joining during switch recombination in patients with ataxia-telangiectasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312796200

The many interfaces of Mre11

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M312796200

IgH class switch recombination to IgG1 in DNA-PKcs-deficient B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312796200

21 January 2018

Identifiers

DOI

10.1074/JBC.M312796200

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12 January 2018

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12 January 2018