사람에게서 발견되는 단백질
mRNA 해독 효소 1A 는 인간에서 DCP1A 유전자 에 의해 암호화된 단백질 이다.[5]
디코딩은 일반적으로 규제된 mRNA 붕괴의 핵심 단계다. 이 유전자에 의해 암호화된 단백질은 해독 효소다. 이 단백질과 또 다른 해독 효소는 해독 복합체를 형성하며, 이 복합체는 난센스 매개 부패 계수 hUpf1과 상호작용하며 조기 종단 코돈을 포함하는 mRNA에 모집될 수 있다. 이 단백질은 또한 TGF-베타 신호 경로에 참여한다.[5]
상호작용 DCP1A는 DCP2 [6] UPF1 과 상호작용 하는 것으로 나타났다.[6] 또한 GW182 와 다른 P-body 마커로 콜로컬라이징하는 것으로 나타났다.[7] 인간 DCP1A는 이성애적이며 [8] [9] 아라비도시스 탈리아 나 호몰로로그는 식물 고유의 타입 XI 미오신 운동 단백질과 상호작용한다.[10]
참조 ^ a b c GRCh38: 앙상블 릴리스 89: ENSG00000272886 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG000021962 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b "Entrez Gene: DCP1A DCP1 decapping enzyme homolog A (S. cerevisiae)" .^ a b Lykke-Andersen J (December 2002). "Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay" . Molecular and Cellular Biology . 22 (23): 8114–8121. doi :10.1128/MCB.22.23.8114-8121.2002 . PMC 134073 PMID 12417715 . ^ Eystathioy T, Jakymiw A, Chan EK, Séraphin B, Cougot N, Fritzler MJ (October 2003). "The GW182 protein colocalizes with mRNA degradation associated proteins hDcp1 and hLSm4 in cytoplasmic GW bodies" . RNA . 9 (10): 1171–1173. doi :10.1261/rna.5810203 . PMC 1370480 PMID 13130130 . ^ Tritschler F, Braun JE, Motz C, Igreja C, Haas G, Truffault V, et al. (December 2009). "DCP1 forms asymmetric trimers to assemble into active mRNA decapping complexes in metazoa" . Proceedings of the National Academy of Sciences of the United States of America . 106 (51): 21591–21596. Bibcode :2009PNAS..10621591T . doi :10.1073/pnas.0909871106 PMC 2789166 PMID 19966221 . ^ Tritschler F, Eulalio A, Truffault V, Hartmann MD, Helms S, Schmidt S, et al. (December 2007). "A divergent Sm fold in EDC3 proteins mediates DCP1 binding and P-body targeting" . Molecular and Cellular Biology . 27 (24): 8600–8611. doi :10.1128/MCB.01506-07 . PMC 2169425 PMID 17923697 . ^ Steffens A, Jaegle B, Tresch A, Hülskamp M, Jakoby M (April 2014). "Processing-body movement in Arabidopsis depends on an interaction between myosins and DECAPPING PROTEIN1" . Plant Physiology . 164 (4): 1879–1892. doi :10.1104/pp.113.233031 PMC 3982750 PMID 24525673 .
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