호모 사피엔스 종의 단백질 코드 유전자
단백질을 포함 한 데스 이펙터 도메인 은 DEDD [5] [6] [7] 유전자 에 의해 인간에게 암호화되는 단백질 이다.
기능. 이 유전자는 데스 이펙터 도메인(DED)을 포함하는 단백질을 암호화한다. DED는 프로그램된 세포사망 경로의 어댑터, 조절자 및 실행자가 공유하는 단백질-단백질 상호작용 도메인이다. 이 유전자의 과발현은 약한 아포토시스 를 유도하는 것으로 나타났다.자극 시, 이 단백질은 세포질에서 핵으로 이동 하며 핵에서 RNA 중합효소 I 전사 에 필요한 기본 인자 인 UBTF로 열량 조절하는 것으로 밝혀졌다. 이 [7]
상호 작용 DEDD는 다음 제품과 상호작용하는 것 으로 나타났습니다.
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000158796 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000013973 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b Stegh AH, Schickling O, Ehret A, Scaffidi C, Peterhänsel C, Hofmann TG, Grummt I, Krammer PH, Peter ME (Dec 1998). "DEDD, a novel death effector domain-containing protein, targeted to the nucleolus" . EMBO J . 17 (20): 5974–86. doi :10.1093/emboj/17.20.5974 . PMC 1170924 PMID 9774341 . ^ Leo CP, Hsu SY, McGee EA, Salanova M, Hsueh AJ (Dec 1998). "DEFT, a novel death effector domain-containing molecule predominantly expressed in testicular germ cells" . Endocrinology . 139 (12): 4839–48. doi :10.1210/endo.139.12.6335 PMID 9832420 . ^ a b "Entrez Gene: DEDD death effector domain containing" .^ a b Zhan Y, Hegde R, Srinivasula SM, Fernandes-Alnemri T, Alnemri ES (Apr 2002). "Death effector domain-containing proteins DEDD and FLAME-3 form nuclear complexes with the TFIIIC102 subunit of human transcription factor IIIC" . Cell Death Differ . 9 (4): 439–47. doi :10.1038/sj.cdd.4401038 PMID 11965497 . ^ a b Roth W, Stenner-Liewen F, Pawlowski K, Godzik A, Reed JC (Mar 2002). "Identification and characterization of DEDD2, a death effector domain-containing protein" . J. Biol. Chem . 277 (9): 7501–8. doi :10.1074/jbc.M110749200 PMID 11741985 . ^ Stegh AH, Schickling O, Ehret A, Scaffidi C, Peterhänsel C, Hofmann TG, Grummt I, Krammer PH, Peter ME (Oct 1998). "DEDD, a novel death effector domain-containing protein, targeted to the nucleolus" . EMBO J . 17 (20): 5974–86. doi :10.1093/emboj/17.20.5974 . PMC 1170924 PMID 9774341 . ^ Alcivar A, Hu S, Tang J, Yang X (Jan 2003). "DEDD and DEDD2 associate with caspase-8/10 and signal cell death" . Oncogene . 22 (2): 291–7. doi :10.1038/sj.onc.1206099 PMID 12527898 .
추가 정보 Park MY, Ryu SW, Kim KD, Lim JS, Lee ZW, Kim E (2005). "Fas-associated factor-1 mediates chemotherapeutic-induced apoptosis via death effector filament formation" . Int. J. Cancer . 115 (3): 412–8. doi :10.1002/ijc.20857 PMID 15688372 . Alcivar A, Hu S, Tang J, Yang X (2003). "DEDD and DEDD2 associate with caspase-8/10 and signal cell death" . Oncogene . 22 (2): 291–7. doi :10.1038/sj.onc.1206099 PMID 12527898 . Lee JC, Schickling O, Stegh AH, Oshima RG, Dinsdale D, Cohen GM, Peter ME (2002). "DEDD regulates degradation of intermediate filaments during apoptosis" . J. Cell Biol . 158 (6): 1051–66. doi :10.1083/jcb.200112124 . PMC 2173221 PMID 12235123 . Zhan Y, Hegde R, Srinivasula SM, Fernandes-Alnemri T, Alnemri ES (2002). "Death effector domain-containing proteins DEDD and FLAME-3 form nuclear complexes with the TFIIIC102 subunit of human transcription factor IIIC" . Cell Death Differ . 9 (4): 439–47. doi :10.1038/sj.cdd.4401038 PMID 11965497 . Schickling O, Stegh AH, Byrd J, Peter ME (2002). "Nuclear localization of DEDD leads to caspase-6 activation through its death effector domain and inhibition of RNA polymerase I dependent transcription" . Cell Death Differ . 8 (12): 1157–68. doi :10.1038/sj.cdd.4400928 PMID 11753564 . Roth W, Stenner-Liewen F, Pawlowski K, Godzik A, Reed JC (2002). "Identification and characterization of DEDD2, a death effector domain-containing protein" . J. Biol. Chem . 277 (9): 7501–8. doi :10.1074/jbc.M110749200 PMID 11741985 .